A5068414982- Prion Diseases and Protein Misfolding
- Neurological diseases and metabolism
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Trace Elements in Health
- Cancer-related gene regulation
- Amino Acid Enzymes and Metabolism
- Polyamine Metabolism and Applications
- Neurological and metabolic disorders
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Microtubule and mitosis dynamics
- Biotin and Related Studies
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- RNA regulation and disease
Institut Pasteur
2016
Finnish Transport Safety Agency
2015
Modèles Insectes de l'Immunité Innée
2015
Inserm
2011
Institut Gustave Roussy
2011
Abstract Prion diseases are caused by misfolding of the cellular protein PrP C to an infectious conformer, Sc . Intercellular transfer propagates conversion and allows infectivity move from periphery brain. However, how prions spread between cells central nervous system is unclear. Astrocytes specialized non-neuronal within brain that have a number functions indispensable for homeostasis. Interestingly, they one earliest sites prion accumulation in A fundamental question arising this...
The Prion Protein (PrP) is an ubiquitously expressed glycosylated membrane protein attached to the external leaflet of plasma via a glycosylphosphatidylinositol anchor (GPI). While misfolded PrPSc scrapie isoform infectious agent prion disease, cellular (PrPC) enigmatic with unclear function. Of interest, PrP localization in polarized MDCK cells controversial and its mechanism trafficking not clear. Here we investigated traffic on filters three-dimensional cysts, more physiological model...
Quantitative thresholds are helpful to define an abnormal DaT SPECT in patients with suspected nigrostriatal degenerative diseases (NSDD). The optimal DaTQUANT threshold for diagnostic accuracy of across combined movement and cognitive disorder populations has been previously described.