A5055763125- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- HIV/AIDS Research and Interventions
- Infectious Diseases and Tuberculosis
- Adolescent and Pediatric Healthcare
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS oral health manifestations
- HIV, Drug Use, Sexual Risk
- Infectious Diseases and Mycology
- Autoimmune and Inflammatory Disorders Research
- vaccines and immunoinformatics approaches
- Hepatitis C virus research
- Immune Cell Function and Interaction
- HIV-related health complications and treatments
- Antimicrobial Peptides and Activities
Rutgers, The State University of New Jersey
2017-2025
Thomas Jefferson University
2025
Rutgers New Jersey Medical School
2016-2025
Clinical trials and practice have shown that ethambutol is an important component of the first-line tuberculosis (TB) regime. This contrasts drug's rather modest potency lack activity against nongrowing persister mycobacteria. The standard plasma-based pharmacokinetic-pharmacodynamic profile suggests drug may be limited clinical value. Here, we hypothesized this apparent contradiction explained by favorable penetration into TB lesions. First, utilized novel in vitro lesion pharmacokinetic...
Understanding the distribution patterns of antibiotics at site infection is paramount to selecting adequate drug regimens and developing new antibiotics. Tuberculosis (TB) lung lesions are made various immune cell types, some which harbor persistent forms pathogen, Mycobacterium tuberculosis. By combining high resolution MALDI MSI with histology staining quantitative image analysis in rabbits active TB, we have mapped a fluoroquinolone resolution, identified immune-pathological factors...
Nontuberculous mycobacterial pulmonary disease (NTM-PD) is a potentially fatal infectious requiring long treatment duration with multiple antibiotics and against which there no reliable cure. Among the factors that have hampered development of adequate drug regimens lack an animal model reproduces NTM lung pathology required for studying antibiotic penetration efficacy. Given documented similarities between tuberculosis immunopathology in patients, we first determined rabbit active key...
Adult-onset Still’s Disease (AOSD) is a rare autoimmune disorder causing systemic inflammation that presents with rash, fever, polyarthritis, and characteristic serum hyperferritinemia. There complex relationship between infections disease, however, the association of AOSD lyme disease not well established. Here we present case in 29-year-old male recent history disease. After ruling out infection malignancy, diagnosis was made. From this report, aim to raise more awareness for recommend...
Abstract Background Primary care providers often lack familiarity with pre-exposure prophylaxis (PrEP) for HIV and miss screening high-risk behavior. From 2017-2019 the Academic Internal Medicine Clinic (AIMC) at University Hospital in Newark, NJ averaged 2 PrEP prescriptions/year. Multiple resident lectures to improve treatment saw minimal improvement 4 prescriptions/year from 2020 2021, all of which were refills. This QA/QI project uses Epic smart tools speed integration guideline directed...
Abstract Background Due to numerous structural factors, transgender (TG) individuals are disproportionately affected by HIV in the United States. Prioritizing PrEP for this population remains a priority. In 2020, only an estimated 3% of TG were taking PrEP. However, one study showed that women who had access gender-affirming care more likely discuss use with their healthcare provider. This aims evaluate prescription patterns among seen our integrated infectious disease and practice. Methods...
Abstract Background With advances in antiretroviral therapy, life-expectancy for people living with HIV (PLWH) has increased. Many specialists function as primary care providers PLWH and are often the front-line of defense when it comes to preventative healthcare. The Infectious Disease Practice (IDP) at University Hospital Newark, NJ serves a medical home site many PLWH. clinic incorporates healthcare measures into providing whole patient well focusing on specific care. Here, we present...
Abstract Background In 2015 emtricitabine-tenofovir (PrEP) was approved for use as a pre-exposure prophylactic medication preventing HIV infections. 2017, WHO declared PrEP to be an essential medicine, gaining widespread acceptance outpatient care. 2020, the COVID-19 pandemic disrupted healthcare system, with several studies showing lower rates of prescriptions during particularly among Black and Latinx groups. Methods Medical records at Rutgers New Jersey School (NJMS) were queried from...