A5086724574- Pancreatic function and diabetes
- Animal Genetics and Reproduction
- Birth, Development, and Health
- Robotics and Sensor-Based Localization
- Digestive system and related health
- Pregnancy and preeclampsia studies
- Inertial Sensor and Navigation
- Genetic and Kidney Cyst Diseases
- Epigenetics and DNA Methylation
- Estrogen and related hormone effects
- Biochemical Analysis and Sensing Techniques
- Preterm Birth and Chorioamnionitis
- Target Tracking and Data Fusion in Sensor Networks
- Neonatal Respiratory Health Research
Australian National University
1993-2024
Tongji University
2011
Shanghai First Maternity and Infant Hospital
2009
The University of Western Australia
1990
Overexposure of the fetus to glucocorticoids early in gestation is detrimental fetal development. Glucocorticoid concentrations circulation are kept low by 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2, encoded HSD11B2) placental syncytiotrophoblasts. However, cytotrophoblasts, progenitors syncytiotrophoblasts, express levels 11β-HSD2. Here we studied molecular mechanisms underlying 11β-HSD2 induction upon syncytialization. Freshly isolated human term cytotrophoblasts and vitro...
Human amnion fibroblasts produce abundant prostaglandins toward the end of gestation, which is one major events leading to parturition. In marked contrast its well-described antiinflammatory effect, glucocorticoids have been shown up-regulate cyclooxygenase-2 (COX-2) expression in human fibroblasts. The mechanisms underlying this paradoxical induction COX-2 by not resolved. Using cultured fibroblasts, we found that mRNA cortisol was a glucocorticoid receptor (GR)-dependent process requiring...
Pancreatic and intestinal growth rates were measured in mice fed on raw soya-bean flour (RSF) for up to 24 weeks. Control animals standard chow. The effects of RSF the mouse pancreas resembled that seen rats, showing hypertrophy with some hyperplasia. A marked increase small weight was also found but not rats this diet. Histological studies showed an both villous crypt thicknesses intestine from these mice, DNA, RNA protein measurements indicated due hyperplasia mucosal layer. To determine...
Abstract Nuclei of pancreatic cells were isolated by trypsin‐detergent digestion fresh tissue and stained with propidium iodide, nuclear DNA was measured flow cytometry. Samples from mice fed either chow or raw soya flour (RSF) for periods ranging day to 48 weeks, beginning at 4 weeks age. In chow‐fed mice, the pancreas contained about 80% diploid (2N) 20% tetraploid (4N) start study, but tetraploidy gradually increased 40% 2 later (6 age) remained this level that time onwards. Low levels...
Stochastic inference on Lie groups plays a key role in state estimation problems such as; inertial navigation, visual odometry, pose virtual reality, etc. A problem is fusing independent concentrated Gaussian distributions defined at different reference points the group. In this paper we approximate group single set of exponential coordinates and then use classical fusion to obtain fused posteriori those coordinates. We consider several approximations including exact Jacobian change...