A5013000361- Childhood Cancer Survivors' Quality of Life
- Renal and related cancers
- Neuroblastoma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Sarcoma Diagnosis and Treatment
- Renal cell carcinoma treatment
- Glioma Diagnosis and Treatment
- Testicular diseases and treatments
- Histiocytic Disorders and Treatments
- Reproductive Biology and Fertility
- Neurofibromatosis and Schwannoma Cases
- Chronic Kidney Disease and Diabetes
- Cancer therapeutics and mechanisms
- Reproductive Health and Technologies
- Hedgehog Signaling Pathway Studies
- Adrenal and Paraganglionic Tumors
- Neuroendocrine Tumor Research Advances
- Multiple and Secondary Primary Cancers
- Chemotherapy-induced cardiotoxicity and mitigation
- Thyroid Disorders and Treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Methemoglobinemia and Tumor Lysis Syndrome
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Urological Disorders and Treatments
Gdańsk Medical University
2015-2025
University Clinical Centre
2019-2023
LMU Klinikum
2020
Nicolaus Copernicus University
2012
Palmetto Hematology Oncology
2010
KU Leuven
2001
Larotrectinib is a first-in-class, highly selective tropomyosin receptor kinase (TRK) inhibitor approved to treat adult and pediatric patients with TRK fusion-positive cancer. The aim of this study was evaluate the efficacy safety larotrectinib in primary central nervous system (CNS) tumors.Patients CNS tumors from two clinical trials (NCT02637687, NCT02576431) were identified. endpoint investigator-assessed objective response rate (ORR).As July 2020, 33 identified (median age: 8.9 years;...
Glomerular filtration rate (GFR) was evaluated in 32 Wilms' tumour survivors (WTs) a cross-sectional study using 99 Tc-diethylene triamine pentaacetic acid (99 Tc-DTPA) clearance, the Schwartz formula, new equation for chronic kidney disease (CKD), cystatin C serum concentration and Filler formula. Kidney damage established by beta-2-microglobulin (B-2-M) albumin urine excretion, sediment ultrasound examination. Blood pressure measured. No differences were found between mean GFR Tc-DTPA CKD...
Undifferentiated embryonal sarcomas of the liver (UESL) are extremely rare and continue to pose a diagnostic therapeutic challenge. The aim study was present multicenter experience German CWS Polish PPSTG groups in treatment UESL children.Twenty-five patients were treated according CWS-96, CWS-2002, CYVADIC protocols. Distant metastases observed four cases (16%). In cases, an initial disease presentation mimicked other entities. A pure cystic appearance mass led misdiagnosis hydatid cyst...
In recent years, researchers have been paying special attention to the tumor microenvironment (TME). One of most important factors contributing development and progression cancer is destruction elements extracellular matrix (ECM). The substances involved in regulating degradation process are metalloproteinases (MMPs) their inhibitors (TIMPs). cell migration, chemokines secreted by target tissues, as well profile chemokine receptors presented on cells, play a key role. work, five components...
Background/Objectives: The high sensitivity of paediatric nurses directly influences the quality nursing care provided to patients. purpose this study is present most frequent issues faced by in their everyday work and responses difficult situations at work, define actions applied when a situation occurs, assess level stress other factors influencing experienced nurses. Methods: This was conducted using an original survey form standardised psychological questionnaire based on Perceived...
<i>Aims:</i> To test the hypothesis that Wilms tumour survivors (WTs) experience increased disturbance in renal function, even after prompt treatment, compared to patients with unilateral agenesis (URA). <i>Methods:</i> assess function of 30 WTs and 17 individuals URA, estimated glomerular filtration rate (eGFR) was calculated using Schwartz Filler formulas as well new equation for chronic kidney disease. measure damage, serum levels urine excretion...
This study presents a unique series of malignant supratentorial gliomas in children previously cured from non-CNS primary cancer. On neuroimaging these tumors were not specific, so the patients suspected cerebral recurrence their neoplasm: leukemia four and sarcoma one child. Histologically, group contained glioblastomas anaplastic astrocytoma. Three underwent neurosurgical resection, while other two stereotactic diagnostic biopsy only. Despite combined oncological treatment, died during 20...
Purpose: Within a multicenter European study, we explored fertility-related wishes, concerns, and decision-making of adolescent cancer patients their parents. Patients Methods: parents were each asked to complete questionnaire 3 months after initial diagnosis. In total, 113 142 (79.6%) eligible participated; 53.1% male the median age was 16 years (range 13–20 years). The completed by 111 Univariate analyses conducted using nonparametric methods with alpha = 5%. For multivariate analyses,...
Abstract Introduction/Objectives Fertility preservation is a major concern for adolescent cancer patients; yet, educational gaps remain. Our intervention study examined whether specially designed materials regarding fertility increase knowledge and empowerment of patients parents. Methods Eleven paediatric‐oncological centres in four European countries agreed to enrol all eligible parents questionnaire survey at 3 6 months after diagnosis. Treating physicians were surveyed on their medical...
Abstract Introduction The aim of this literature review was to explore the views parents and children with type 1 diabetes mellitus regarding having a school nurse. Methods Six databases were selected for analysis. research strategy based on PICO model. participants and/or their parents. Results present papers includes 12 publications. majority works deal perspectives various aspects related role nurse in care child diabetes: presence nurse; prevention treatment hypoglycaemia, performing...
Abstract Anti‐cancer treatment in children can deteriorate gonadal function and affect future fertility. We analyzed the hormonal markers of adolescent leukemia survivors, treated childhood with different levels aggressiveness. hormone 69 adolescents young adults, survivors stratified into standard (SR), intermediate (IR), high (HR) risk groups, 80 healthy controls (38 men) at a similar age. assessed follicular stimulating (FSH), luteinizing (LH), inhibin B whole group, testosterone males,...
A focal lesion in the region of adrenal gland a newborn often requires further assessment. Ultrasound (US) is initial imaging method choice young children as it does not use radiation or require sedation and has excellent spatial resolution. In this case series, we present contrast-enhanced ultrasound (CEUS) problem-solving tool evaluation neonatal lesions.The medical records five patients with lesions were retrospectively reviewed. All underwent US an examination all had follow-up....
Abstract Choriocarcinoma in neonates and infants (N‐CC) is an extremely rare, but aggressive cancer, frequently observed with concomitant maternal disease. A retrospective, bi‐national study of patients treated France Poland for infantile choriocarcinoma analysed eight cases N‐CC, median age 6 weeks. All tumours were diffuse. Six received a platinum‐based regimen, five had delayed surgery on residual distant tumour sites. At the end follow‐up, four complete remission died In all two cases,...
A case of an epidural spinal peripheral primitive neuroectodermal tumor (pPNET) in a 13‐year‐old girl is presented. The was disseminated at the moment diagnosis, thus only diagnostic oligobiopsy mass performed. Histologically composed small round blue cells. neoplastic cells expressed MIC2 and features neural differentiation on immunohistochemical staining (neuron‐specific enolase, synaptophysin NCAM positivity). Fluorescent situ hybridization (FISH) analysis performed for final diagnosis...
Abstract Background This study presents a clinical, biochemical, and sonographic evaluation of single kidneys in Wilms tumor survivors. Procedure The function 26 survivors (mean age, 11.17 years; mean follow‐up, 7.09 years) was evaluated using cystatin C (CysC) levels compared to serum creatinine concentration glomerular filtration rate (eGFR), the latter which estimated by Schwartz formula. length kidney, resistance index (RI) renal vessels, parenchymal thickness/kidney ratio (PT/KL) were...