A5067259340- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Safe Handling of Antineoplastic Drugs
- Extracellular vesicles in disease
- Food Allergy and Anaphylaxis Research
- HIV Research and Treatment
- Contact Dermatitis and Allergies
- Genomics and Rare Diseases
- Herpesvirus Infections and Treatments
- HIV-related health complications and treatments
- Pharmacy and Medical Practices
- Cell Adhesion Molecules Research
- melanin and skin pigmentation
- Acne and Rosacea Treatments and Effects
- Synthesis and Reactions of Organic Compounds
- IL-33, ST2, and ILC Pathways
- Anesthesia and Sedative Agents
- Viral gastroenteritis research and epidemiology
- Immune Cell Function and Interaction
- Eosinophilic Disorders and Syndromes
- HIV/AIDS Research and Interventions
- Colorectal Cancer Treatments and Studies
- Geochemistry and Geologic Mapping
- Complement system in diseases
- Biosimilars and Bioanalytical Methods
Immunologie - Immunopathologie - Immunothérapie
2023
Sorbonne Université
2014-2023
Pitié-Salpêtrière Hospital
2023
Délégation Centre-Est
2021
Inserm
2011-2018
Bipar
2017
Centre National de la Recherche Scientifique
2014
Institut Curie
2013
Université Paris Cité
2011
Délégation Paris 7
2011
Exosomes are extracellular vesicles (EVs) secreted upon fusion of endosomal multivesicular bodies (MVBs) with the plasma membrane. The mechanisms involved in their biogenesis remain so far unclear although they constitute targets to modulate exosome formation and therefore a promising tool understand functions. We have performed an RNA interference screen targeting twenty-three components sorting complex required for transport (ESCRT) machinery associated proteins MHC class II (MHC...
Abstract Regulatory T cells (Tregs) are pivotal for maintenance of immune self-tolerance and also regulate responses to exogenous Ags, including allergens. Both decreased Treg number function have been reported in allergic patients, offering new therapeutic perspectives. We previously demonstrated that Tregs can be selectively expanded activated by low doses IL-2 (ld-IL-2) inducing immunoregulation without immunosuppression established its protective effect autoimmune diseases. In this...
The induction of an active immune response to control or eliminate tumours is still unfulfilled challenge. We focused on plasmid DNA vaccines using innovative approach whereby the antigen expressed in association with extracellular vesicles (EVs) facilitate cross‐presentation and improve induced immunity. Our two groups had independently shown previously that encoding EV‐associated antigens are more efficient at inducing cytotoxic T‐cell responses than non‐EV‐associated antigen. Here, we...
Cohen syndrome is a rare autosomal recessive inherited disorder that results from mutations of the VPS13B gene. Clinical features consist combination mental retardation, facial dysmorphism, postnatal microcephaly, truncal obesity, slender extremities, joint hyperextensibility, myopia, progressive chorioretinal dystrophy, and intermittent neutropenia.The aim study was to determine which above clinical were best indicators for presence gene in series 34 patients with suspected referred...
ABSTRACT Retrovirus-derived virus-like particles (VLPs) are particularly interesting vaccine platforms, as they trigger efficient humoral and cellular immune responses can be used to display heterologous antigens. In this study, we characterized the intrinsic immunogenicity of VLPs investigated their possible adjuvantization by incorporation Toll-like receptor (TLR) ligands. We designed a noncoding single-stranded RNA (ncRNA) that could encapsidated induce TLR7/8 signaling. found efficiently...
HLA-G is a non-classical HLA class I molecule with tolerogenic properties and restricted tissue distribution. The expression of can be induced by tumors thus providing an efficient way to escape the anti-tumoral immune response. Although lipid rafts regulate diverse immunological mechanisms their relationship remains controversial. Our results show that HLA-G-mediated inhibition both interaction between NK tumor cells, intracellular calcium flux in cells conjugated target were independent...
Mucosal surfaces serve as the primary entry points for pathogens such SARS- CoV-2 coronavirus or HIV in human body. vaccination plays a crucial role to successfully induce long-lasting systemic and local immune responses confer sterilizing immunity. However, antigen formulations delivery methods must be properly selected since they are decisive quality magnitude of elicited mucosa. We investigated significance using particulate forms mucosal by comparing VLP- protein- based vaccines mouse...
<h3>Background and importance</h3> Patients hospitalised in intensive care units (ICUs) often require the use of multiple drugs, intravenous (IV) route is most common mode administration. IV access usually limited, leading to concomitant administration different drugs same infusion line. A previous work<sup>1</sup> identified many administrations via a Y site without compatibility data. list missing data was established. <h3>Aim objectives</h3> From this list, we decided evaluate physical...