A5020003187- Amyotrophic Lateral Sclerosis Research
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Retinal Development and Disorders
- Tissue Engineering and Regenerative Medicine
- Neuroscience and Neuropharmacology Research
- Neurogenetic and Muscular Disorders Research
- biodegradable polymer synthesis and properties
- Neurogenesis and neuroplasticity mechanisms
- Drug Transport and Resistance Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Cardiac Fibrosis and Remodeling
- Electrospun Nanofibers in Biomedical Applications
- Connexins and lens biology
- Lysosomal Storage Disorders Research
- Glycosylation and Glycoproteins Research
- Neuroblastoma Research and Treatments
- Alzheimer's disease research and treatments
- Prion Diseases and Protein Misfolding
Universidade Federal do Rio de Janeiro
2021-2024
National Institute of Science and Technology in Regenerative Medicine
2022
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
2021-2022
Universidade Federal Fluminense
2015-2021
Abstract Amyloid precursor protein (APP) is essential to physiological processes such as synapse formation and neural plasticity. Sequential proteolysis of APP by beta‐ gamma‐secretases generates amyloid‐beta peptide (Aβ), the main component senile plaques in Alzheimer Disease. Alternative cleavage alpha‐secretase occurs within Aβ domain, releasing soluble α‐APP (sAPPα), a neurotrophic fragment. Among other functions, sAPPα important synaptogenesis, survival axonal growth. levels are...
Abstract Monocular eye enucleation (ME) is a classical paradigm to induce neural plasticity in retinal ganglion cells (RGCs) axons from the intact eye, especially when performed within critical period of visual system development. However, precise mechanisms underlying axonal sprouting and synaptogenesis seen this model remain poorly understood. In present work, we investigated temporal alterations phosphorylation three kinases related growth synaptogenesis—GSK3β (an important repressor...