A5001270344- Pulmonary Hypertension Research and Treatments
- Reproductive Biology and Fertility
- Liver Disease and Transplantation
- Angiogenesis and VEGF in Cancer
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Medical Imaging and Pathology Studies
- Respiratory Support and Mechanisms
- Assisted Reproductive Technology and Twin Pregnancy
- Chronic Myeloid Leukemia Treatments
- Transplantation: Methods and Outcomes
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cardiovascular Function and Risk Factors
- Acute Lymphoblastic Leukemia research
- Ovarian function and disorders
- Trauma and Emergency Care Studies
- Fibroblast Growth Factor Research
- Peripheral Artery Disease Management
- Cardiac tumors and thrombi
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Inflammatory Biomarkers in Disease Prognosis
- Venous Thromboembolism Diagnosis and Management
- Macrophage Migration Inhibitory Factor
- Spaceflight effects on biology
- Hydrogen's biological and therapeutic effects
Amsterdam University Medical Centers
2018-2024
Eastern Virginia Medical School
2024
Vrije Universiteit Amsterdam
2014-2021
University of Amsterdam
2021
Amsterdam UMC Location Vrije Universiteit Amsterdam
2017-2020
Pulmonary Associates
2018-2019
Yale University
2008-2009
Fertilitetscentrum
2008
Shady Grove Fertility Center
2008
McGill University
2008
The major complication of COVID-19 is hypoxaemic respiratory failure from capillary leak and alveolar oedema. Experimental early clinical data suggest that the tyrosine-kinase inhibitor imatinib reverses pulmonary leak. This randomised, double-blind, placebo-controlled, trial was done at 13 academic non-academic teaching hospitals in Netherlands. Hospitalised patients (aged ≥18 years) with COVID-19, as confirmed by an RT-PCR test for SARS-CoV-2, requiring supplemental oxygen to maintain a...
STUDY QUESTIONIs the selection of a single Day 3 embryo by metabolomic profiling culture medium with near-infrared (NIR) spectroscopy as an adjunct to morphology able improve live birth rates in IVF, compared alone?
Endothelial barrier dysfunction leads to edema and vascular leak, causing high morbidity mortality. Previously, Abl kinase inhibition has been shown protect against leak. Using the distinct inhibitory profiles of clinically available inhibitors, we aimed provide a mechanistic basis for novel treatment strategies leakage syndromes. We found that inhibitor bosutinib most potently protected inflammation-induced endothelial disruption. In vivo, prevented lipopolysaccharide (LPS)-induced alveolar...
In pulmonary arterial hypertension (PAH), lung-angioproliferation leads to increased vascular resistance, while simultaneous myocardial microvessel loss contributes right ventricular (RV) failure. Endothelial colony forming cells (ECFC) are highly proliferative, angiogenic that may contribute either obstruction or RV microvascular adaptation. We hypothesize ECFC phenotypes (outgrowth, proliferation, tube formation) related markers of disease severity in a prospective cohort-study 33 PAH and...
What is the central question of this study? How does interaction between posture and gravity affect stresses on lung, particularly in highly inflated gravitationally non-dependent regions, which are potentially vulnerable to increased mechanical stress injury? main finding its importance? Changes attributable not well characterized postures. Using a new metric gravitational stress, we show that regions lung near maximal inflation have greatest while supine, but prone. In simulations weight...
Rationale: Pulmonary hypertension encompasses progressive disorders leading to right ventricular dysfunction and early death. Late detection is an important cause of poor clinical outcomes. However, biomarkers that accurately predict the presence pulmonary are currently lacking. Objectives: In this study, we provide evidence blood platelets contain a distinctive ribonucleic acid (RNA) profile may be exploited for hypertension. Methods: Blood platelet RNA was isolated prospectively from 177...
BackgroundTrauma-induced shock is associated with endothelial dysfunction. We examined whether the tyrosine kinase inhibitor bosutinib as an adjunct therapy to a balanced blood component resuscitation strategy reduces trauma-induced permeability, thereby improving reversal and limiting transfusion requirements organ failure in rat polytrauma model.MethodsMale Sprague–Dawley rats (n=13 per group) were traumatised exsanguinated until MAP of 40 mm Hg was reached, then randomised two groups: red...
A 19-year-old woman of Moroccan descent presented with severe dyspnoea on exertion. She had difficulty walking stairs (New York Heart Association functional class 3) and accompanying symptoms included fatigue, palpitations near collapse. no cough or wheezing, but mentioned continuous menstrual bleeds since menarche without use contraceptives. Her medical history long-standing complaints fainting, abdominal pains chest pain, a clear diagnosis. The family hypercholesterolaemia venous...
Pulmonary arterial hypertension is a heterogeneous group of diseases characterized by vascular cell proliferation leading to pulmonary remodelling and ultimately right heart failure. Previous data indicated that 3'-deoxy-3'-[18F]-fluorothymidine (
Dysfunction of the endothelial barrier leads to uncontrolled fluid extravasation and vascular leak, yielding high morbidity mortality. We previously demonstrated that Abl kinase inhibition protects against leak. Since then, next generation AKIs were developed with broader better safety profiles. The current study aims evaluate whether combined as provided by AKIs, provides novel therapy strategies leakage. A screen on second third revealed bosutinib (Bosulif®) has protective effects barrier,...