A5023534770- Tissue Engineering and Regenerative Medicine
- Salivary Gland Disorders and Functions
- Congenital heart defects research
- Dental Implant Techniques and Outcomes
- Cancer Cells and Metastasis
- Periodontal Regeneration and Treatments
- Lymphatic System and Diseases
- Biomarkers in Disease Mechanisms
- Dental Radiography and Imaging
- Glaucoma and retinal disorders
- Dental materials and restorations
- Pediatric health and respiratory diseases
- Dental Erosion and Treatment
- Pancreatic and Hepatic Oncology Research
- Endodontics and Root Canal Treatments
- Dental Research and COVID-19
- Reconstructive Surgery and Microvascular Techniques
- Cardiac Fibrosis and Remodeling
- Cancer Immunotherapy and Biomarkers
- Muscle Physiology and Disorders
- Cellular transport and secretion
- Salivary Gland Tumors Diagnosis and Treatment
- Mesenchymal stem cell research
- dental development and anomalies
- Cardiac Imaging and Diagnostics
Institutul National Victor Babes
2013-2024
Carol Davila University of Medicine and Pharmacy
2014-2024
University of Dental Medicine
2021
In the last few years, a new cell type – interstitial Cajal-like (ICLC) has been described in digestive and extra-digestive organs. The name recently changed to telocytes (TC) their typical thin, long processes have named telopodes (TP). To support hypothesis that TC may also be present human placenta add information already available, we provide evidence on ultrastructure, immunophenotype, distribution, interactions with surrounding stromal cells of villous core term placenta. We used...
The existence of the epicardial telocytes was previously documented by immunohistochemistry (IHC) or immunofluorescence. We have also demonstrated recently that are present in mice epicardium, within cardiac stem-cell niches, and, possibly, they acting as nurse cells for cardiomyocyte progenitors. rationale this study to show do exist human (sub)epicardium, too. Human autopsy hearts from 10 adults and 15 foetuses were used conventional IHC c-kit/CD117, CD34, vimentin, S-100, τ, Neurokinin 1,...
Pancreatic interstitial cells are located among acini, ducts, nerves, and blood vessels. They essential for pancreas development, physiology, oncogenic microenvironment. We identified with characteristic ultrastructural features of telocytes in pancreatic interstitium. Telocytes were initially described as Cajal-like cells, but it gradually became clear that they a distinct novel cell type not directly related to canonical Cajal cells.Serial ultrathin sections human tissue studied by...
Abstract The parotid histological structure includes acinar, ductal, and myoepithelial cells, surrounded by a connective stromal component. stroma is mostly regarded as an inert shell, consisting of septa, which divide the parenchyma. Telocytes were recently identified new cell type in various organs, including exocrine pancreas. We aimed to evaluate telocytes presence whether their topographical features might support involvement function modulation. Serial ultrathin sections human rat...
Telocytes (TC) are interstitial cells with telopodes (Tp). These prolongations (Tp) quite unique: very long (several tens of micrometres) and thin (≤0.5 μm), moniliform aspect: segments (podomeres) alternating dilations (podoms). To avoid any confusion, TC were previously named Cajal-like (ICLC). Myocardial repeatedly documented by electron microscopy, immunohistochemistry immunofluorescence. form a network their Tp, either in situ or vitro. Cardiac (completely) different 'classic'...
Abstract TCs (telocytes) are actually defined as stromal cells with specific long and thin prolongations, called Tp (telopodes). They have been positively identified in various tissues we now report their presence the esophagus. These were by TEM (transmission electron microscopy) esophageal samples of Wistar rats ( n = 5) occurring beneath basal epithelial layer, submucosa, closely related to smooth striated muscular fibres, also adventitia. mast cells, macrophages microvessels. Hybrid...
Background: Oral hygiene is essential for low caries or gingivitis prevalence in children. This study aimed to determine the oral profile of children from secondary schools (10–17 years) Bucharest, Romania, and explore options preventing their future diseases. Methods: The was cross-sectional, with a sample n = 1595 pupils. stratified by clusters city areas, grades, criterion presence/absence in-school dental service. Dental check-ups were performed using commune examination kit. simplified...
We aimed to validate the safety and efficacy of minimally invasive "open healing" flapless technique for post-extraction socket alveolar ridge preservation, while assessing bone changes. The study enrolled (n = 104) patients (0.55 sex ratio), with atraumatic extraction (N 135) hopeless teeth, followed by either immediate placement tissue level implants (N1 26), or later stage implant insertion (N2 109). No flap was raised in situation. Post-extraction sockets were filled deproteinized bovine...
Experimental studies regarding coronary embryogenesis suggest that the endocardium is a source of endothelial cells for myocardial networks. As this was not previously documented in human embryos, we aimed to study whether or tip could be correlated with endocardial-dependent mechanisms sprouting angiogenesis. Six embryos (43-56 days) were obtained and processed accordance ethical regulations; immunohistochemistry performed CD105 (endoglin), CD31, CD34, α-smooth muscle actin, desmin vimentin...
The presence of hyaline cartilage has been previously documented in heart tissue different vertebrates, ranging from birds to superior mammals. However, there is scarce published data regarding the appearance focal deposits hyaline-like within hearts laboratory rats. Few mechanisms that could trigger this type were hypothesized (e.g., mechanical stress, ageing). Using microscopy techniques report confirms and bone Wistar rats, which underwent left anterior coronary artery ligation for...
An innate osteogenic potential of the Schneiderian membrane (SM) is progressively assessed in studies ranging from non-human species to human subjects. It has relevance for endosteal placement and osseointegration. Nestin-expressing progenitor cells are allegedly involved bone formation remodelling. Nestin phenotype was not previously SM. We therefore aimed fill that particular gap literature. Bioptic samples adult SM were obtained during surgery eight patients, operated non-malignant...
Telocytes (TCs) are a peculiar morphological type of stromal cells. They project long and moniliform telopodes, visible on various bidimensional sections. Originally regarded as "interstitial Cajal-like cells", gastrointestinal TCs were CD34+. Further double-labelling studies found that colon negative for the expressions PDGFR-α α-SMA. However, in not distinguished specifically from endothelial cells (ECs), vascular or lymphatic. A combinational approach is important accurate TC...
Abstract An accurate identification of telocytes (TCs) was limited because the heterogeneity cell types expressing markers attributed to TCs. Some endothelial lineage cells also could fit within pattern Such line conjunctival lacunae previously assessed by laser confocal microscopy. We have been suggested that an distinction TCs from in human eye conjunctiva be achieved use CD31, CD34 and D2‐40 (podoplanin); are fact lymphatic. aimed as testing hypothesis immunohistochemical study on biopsy...
Abstract Stromal cells appear as paraductal networks in the human parotid gland. are immunostained with vimentin. See Figure 1 (left panel) Nicolescu et al., on page 380, this issue.