A5069922087- Supramolecular Chemistry and Complexes
- Chemical Synthesis and Analysis
- Carbohydrate Chemistry and Synthesis
- Synthesis and Properties of Aromatic Compounds
- Supramolecular Self-Assembly in Materials
- Crystallography and molecular interactions
- Crystallization and Solubility Studies
- Luminescence and Fluorescent Materials
- Glycosylation and Glycoproteins Research
- DNA and Nucleic Acid Chemistry
- Organometallic Complex Synthesis and Catalysis
- X-ray Diffraction in Crystallography
- Molecular Sensors and Ion Detection
- Fluorine in Organic Chemistry
- Synthetic Organic Chemistry Methods
- Biochemical and Molecular Research
- Lysosomal Storage Disorders Research
- Cancer therapeutics and mechanisms
- Cyclopropane Reaction Mechanisms
Universität Ulm
2021-2025
NCCR Chemical Biology - Visualisation and Control of Biological Processes Using Chemistry
2021
University of Geneva
2021
Centre National de la Recherche Scientifique
2020
Université Toulouse III - Paul Sabatier
2020
Cycloparaphenylenes (CPPs) represent a significant challenge for the synthesis of mechanically interlocked architectures, because they lack heteroatoms, which precludes traditional active and passive template methods. To circumvent this problem explore fundamental functional properties CPP rotaxanes catenanes, researches have resorted to unusual non‐covalent even labor‐intensive covalent approaches. Herein, we report ring‐in‐ring strategy that makes use surprisingly strong inclusion crown...
Advances in supramolecular chemistry are often underpinned by the development of fundamental building blocks and methods enabling their interconversion. In this work, we report use an underexplored dynamic covalent reaction for synthesis stimuli-responsive [2]rotaxanes. The formamidinium moiety lies at heart these mechanically interlocked architectures, because it enables both exchange binding simple crown ethers. We demonstrated that rotaxane self-assembly follows a unique pathway complex...
Cycloparaphenylenes (CPPs) represent a significant challenge for the synthesis of mechanically interlocked architectures, because they lack heteroatoms, which precludes traditional active and passive template methods. To circumvent this problem explore fundamental functional properties CPP rotaxanes catenanes, researches have resorted to unusual non‐covalent even labor‐intensive covalent approaches. Herein, we report ring‐in‐ring strategy that makes use surprisingly strong inclusion crown...
A concise and asymmetric synthesis of the enantiomeric pyrrolidines 2 ent-2 are herein reported. Both enantiomers were assessed as β-GCase inhibitors. While compound acted a poor competitive inhibitor, its enantiomer proved to be potent non-competitive inhibitor. Docking studies carried out substantiate their respective protein binding mode. also able enhance lysosomal residual activity in N370S homozygous Gaucher fibroblasts. Notably, inhibitor displayed an enzyme enhancement comparable...
A dual Bcl-XL / Bcl-2 inhibitor was discovered from DNA-encoded libraries using a two steps process. In the first step, DNA used to pair PNA-encoded fragments exploring > 250 000 combinations. second focused library combining selected with linkers of different lengths and geometries led identification tight binding adducts that were further investigated for their selective target engagement in pull-down assays, affinity by SPR, selectivity cytotoxicity assay. The best compound showed...
Cycloparaphenylenes (CPPs) represent a significant challenge for the synthesis of mechanically interlocked architectures, because they lack heteroatoms, which precludes traditional active and passive template methods. To circumvent this problem explore fundamental functional properties CPP rotaxanes catenanes, researches have resorted to unusual non-covalent even labor-intensive covalent approaches. Herein, we report ring-in-ring strategy that makes use surprisingly strong inclusion crown...
Dynamic covalent chemistry has become an invaluable tool for the design and preparation of adaptable yet robust molecular systems. Herein we explore scope a largely overlooked dynamic reaction - amidinium exchange report on conditions that allow formal metathesis reactions.