A5005013992- Cancer Cells and Metastasis
- Cell death mechanisms and regulation
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Liver physiology and pathology
- Parasitic Diseases Research and Treatment
- Glycosylation and Glycoproteins Research
- Pharmacological Effects of Medicinal Plants
- Global Cancer Incidence and Screening
- Essential Oils and Antimicrobial Activity
- Microbial Natural Products and Biosynthesis
- Bioactive Compounds and Antitumor Agents
- 3D Printing in Biomedical Research
- Synthesis and biological activity
- Phytochemicals and Medicinal Plants
- Magnesium Alloys: Properties and Applications
- Silymarin and Mushroom Poisoning
- Pomegranate: compositions and health benefits
- Protein Hydrolysis and Bioactive Peptides
- NF-κB Signaling Pathways
- Estrogen and related hormone effects
- Synthesis of Tetrazole Derivatives
- Phytochemistry and Bioactivity Studies
- Pancreatic function and diabetes
- Bone Metabolism and Diseases
Chaithanya Eye Hospital and Research Institute
2025
Annamalai University
2007-2024
Institute of Bioinformatics
2018-2023
Manipal Academy of Higher Education
2018-2022
Institute for Experimental Endocrinology and Oncology
2022
National Research Council
2022
Anna University, Chennai
1995-2017
Bharathidasan University
2016-2017
Piramal (India)
2007-2013
Medizinische Hochschule Hannover
2013
Aim/Background: Medicinal plants have ability to resist microorganisms by synthesizing secondary metabolites such as phenols.Rosmarinic acid (RA) is a phenylpropanoid widely distributed in and well known therapeutic cosmetic agent.Methicillin-resistant Staphylococcus aureus (MRSA) which resistant all kinds of β-lactams, threatens even most potent antibiotics.To improve the efficiency antibiotics against multi-drug bacteria reduce antibiotic dose, antibacterial activity synergistic effect RA...
Circulating tumor cells (CTCs) are putative markers of prognosis and may serve to evaluate patient's response chemotherapy. CTCs often detected as single but infrequently clusters indicative worse prognosis. In this study, we developed a short-term culture nucleated blood which was applied samples from breast, lung, esophageal bladder cancer patients. Clusters different degrees compactness, classified very tight, tight loose were observed across various types. These show variable expression...
Insulin resistance is characterized by alterations in insulin signaling components thereby resulting reduced glucose uptake. The mechanistic role of (3β)-stigmast-5-en-3-ol augmenting uptake to overcome deciphered this study. L6 myotubes, rat skeletal muscle model have been used check the effect (3β)-stigmast-5-en-3-ol, a plant phytosterol isolated from ethyl acetate extract Adathoda vasica on transport. influence various cellular targets cascade has evaluated using inhibitors as well gene...
Conventional solvent fractionation and bioactivity based target assays were used to identify a new anti-cancer molecule from Phyllanthus urinaria, herbal medicinal plant in South India. At each step of the purification process different fractions that isolated tested for specific anti-proliferative activity by measuring inhibition [3H]thymidine incorporation, trypan blue drug exclusion. The ethyl acetate fraction contained was further purified resolved HPLC on preparative column. purity...
Intravitreal anti-VEGF agents, such as Brolucizumab, play a crucial role in treating neovascular age-related macular degeneration (nAMD) and Polypoidal choroidal vasculopathy (PCV). While Brolucizumab offers advantages like extended duration fewer injections, concerns about intraocular inflammation (IOI) have emerged. This study evaluates the outcomes of proactive monitoring protocol for Brolucizumab-treated eyes with resistant nAMD PCV. A single-center retrospective analyzed patients...
Tannin rich fraction (TRF) isolated from hydroalcoholic extract of Terminalia chebula characterized by Liquid Chromatography-Mass Spectrometry (LC-MS) tested positive for the presence gallic acid, methyl gallate, corilagin, chebulagic and chebulinic acid. The anti-inflammatory activity TRF was studied in vitro models which showed dose-dependent increase activities. At 250 µgmL−1, exhibited 84.48, 84.33, 81.98, 82.3% inhibition protein denaturation, membrane lysis, proteinase, hyaluronidase...
ABSTRACT An in vitro model to examine the effects of filarial proteins on lung epithelial cells has been developed. Several these appear circulation infected individuals. A close association between tropical pulmonary eosinophilia (TPE) and filariasis reported by several workers. [ 3 H]‐thymidine studies do indicate that when optimum concentration were added cultures proliferating basal/maintenance media a further increase growth stimulation was observed early culture. However, longer...
The direct interaction of filarial proteins with lung epithelial cells was examined to determine the possible mechanism inducing cell death, an event that is observed in patients tropical pulmonary eosinophilia. Exposure parasitic proteins, Brugia malayi (BmA), Setaria digitata (Sd), and recombinant protein (pGT 7) vitro for more than 2 days, causes appearance DNA fragments both cytoplasm culture supernatants, while no fragmentation untreated controls. release supernatants simultaneously,...
Abstract Isolation and structure determination of two naphthoquinones, herbarin (I) herbaridine A (II), are described.
ABSTRACT The primary objective of this study is to enhance surface coating characteristics and reduce the dilution rate AZ61 magnesium alloy coated with Stelcar powder through laser cladding. A Taguchi (L16) orthogonal experimental design employed analyze effects scanning speed, power, feed rate, gas flow on wear volume, micro-hardness. Signal-to-noise ratios were calculated for each parameter identify their individual responses. findings indicated that predominantly influenced accounting...
Cyclic aromatic secondary amines, like phthalimides, and related compounds possess structural features, which makes them to exert potential biological activities pharmaceutical applications. A new Mannich base has been synthesized from phthalimide its transition metal complexes also were prepared. The ligand was by using phthalimide, formaldehyde piperidine. as well the characterized various physical methods. structure of are confirmed UV, IR, 1H NMR spectroscopic techniques. antimicrobial...