Increased non high-density lipoprotein (HDL)/low-density (LDL) cholesterol levels are independent risk factors for cardiovascular (CV) mortality with no documented threshold. A new combination of nutraceuticals (berberine 200 mg, monacolin K 3 chitosan 10 mg and coenzyme Q mg) additive lipid-lowering properties has become available. The aim the study is to test efficacy nutraceutical formulation (one daily) in lowering non-HDL vs. placebo at 12 weeks individuals non-HDL-cholesterol ≥160...

Background: Nutraceuticals represent a strategy for maintaining health and constitute brilliant market in Italy across Europe. However, the absence of strict regulations regarding formulation requirements highlights critical issue: their poor bioavailability. An example is coenzyme Q10 (CoQ10), quinone known its potential as mitochondrial protective agent but characterized by low intestinal absorption. CoQ10 hydrophobic molecule with high molecular weight water solubility, factors that...

Astaxanthin is a carotenoid extracted from several seaweeds with ascertained therapeutic activity. With specific reference, astaxanthin widely used in clinical practice to improve ocular tissue health and skin protection UV ray damages. Despite its well-documented pleiotropic actions demonstrated efficacy, bioavailability humans low limited because of hydrophobicity poor dissolution enteric fluids. Furthermore, very unstable molecule sensitive light exposure thermal stress. Taken together,...

to evaluate the efficacy of oral administration a novel composition composed quercetin, curcumin, acetylcysteine in reducing pain women affected by endometriosis, through reduction inflammatory-hyperproliferative component ectopic endometrial tissue.Thirty-three with clinical diagnosis endometriosis from at least 3 months have been enrolled. Patients treated daily 200 mg 210 dry extract Curcuma longa (titrated 95% curcuminoids) and 150 (1 tablet ALLIENDO®) for 2 months. The overall...

Berberine Chloride (BC) is an isoquinolinic alkaloid that extracted from plants of generis Berberis. During the last decade, researchers and clinicians have paid increasing attention to BC, because its impressive hypoglycemic blood lipids lowering properties. Several clinical studies gave proof evidence regarding BC efficacy in humans pharmacological mechanisms action, related previously mentioned activities, been proposed substantially confirmed. On other side, shows a very poor oral...

A new nanoemulsifing system has been developed. This study refers to an innovative association of polysorbate 80 and palmitic ester l-ascorbic acid for the production good stability very thin nanostructured emulsions with average micellar diameter size ranging from 100 300 nm. showed be performing create nanoemulsions moderate stirring rate warming regimen thanks high efficiency between ascorbyl palmitate polysorbate-80 (PS-80). nanoemulsified is easy achieve shows a capability encapsulate...

Chitosan (CH) is a polymer of glucosamine that extracted from the shells several sea fruits. It well recognized as nutritional supplement used to reduce body weight and blood lipid levels, but its clinical efficacy has not been clearly demonstrated. The true mechanism action physiological processes involved in these properties CH are yet understood or explained. most accepted theories assume reduces dietary fat absorption by trapping gastric lumen. very low pH lumen induces jellification...

The effectiveness of statins in the primary and secondary prevention cardiovascular (CV) diseases has been widely proven. However, onset adverse events associated with their use prevents to achieve therapeutic targets recommended by guidelines (GL) for management dyslipidemia. In event statin intolerance, GL recommend bile acid sequestrants, fibrates, ezetimibe monotherapy, but benefits improving lipid pattern are quite modest. This study aims at evaluating safety a nutraceutical compound...

Objective: We aimed to assess the impact of resveratrol on BP through systematic review literature and meta-analysis available randomized, controlled clinical trials (RCTs). Design method: Literature search included SCOPUS, PubMed-Medline, ISI Web Science Google Scholar databases up 17th October 2017 identify RCTs investigating BP. Two authors independently extracted data study characteristics, methods outcomes. Overall, was reported in 17 trials. Results: Administration did not...

The class of lipophilic compounds coming from vegetal source represents a perspective in the adjuvant treatment several human diseases, despite their poor bioavailability humans. These are generally soluble fats and poorly water. major reason for natural after oral uptake humans is related to reduced solubility enteric water-based fluids, leading an ineffective contact with absorbing epithelium. main goal ensure efficacy such then creating technological conditions deliver them into first...

Objective: The effectiveness of statins in the primary and secondary prevention cardiovascular (CV) diseases has been widely proven. However, onset adverse events associated with their use, prevents to achieve therapeutic targets recommended by guidelines (GL) for management dyslipidaemia. In event statin intolerance, is recommend use bile acid sequestrants, fibrates ezetimibe monotherapy, but benefits improving lipid pattern are quite modest. This study aims at evaluating safety a...

Lower Urinary Tract Symptoms (LUTs) in men are usually associated to benign prostatic hyperplasia (BPH), a non-malignant prostate enlargement. Unfortunately, BPH etiology is still unclear. Recent works highlighted relevant inflammation role onset and development. Consequently, complement the 5-α reductase (and α-adrenergic receptor agonists-based therapy, an anti-inflammatory therapy should be devised. To reduce potential adverse effects of multi-drug treatment, plant extract-based therapies...

Trans-resveratrol (RES) and N-acetylcysteine (NAC) have protective effects on biological processes; therefore, they are frequently included in food supplements. Their possible applications for the prevention of free radical-induced damage to skin particular physiological relevance; however, their usefulness is limited by metabolic fate unpredictability delivery following oral administration. In this work, we evaluated concomitant direct application RES NAC using a self-nanoemulsifying system...

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly prescribed and self-prescribed to treat inflammation pain associated with several conditions. Although their efficacy overall safety have been recognized when used according medical prescriptions for a short period time, acute impact on enteric physiology has rarely studied. NSAIDs known cause gastrointestinal side effects due intrinsic mechanism of action, which involves prostaglandins synthesis, leading impaired...