A5024503767- Veterinary Pharmacology and Anesthesia
- Pancreatic and Hepatic Oncology Research
- Anesthesia and Pain Management
- Pancreatic function and diabetes
- Anesthesia and Sedative Agents
- Microbial Inactivation Methods
- Pancreatitis Pathology and Treatment
- Virus-based gene therapy research
- Ultrasound and Hyperthermia Applications
- Veterinary Equine Medical Research
- Microfluidic and Bio-sensing Technologies
- Thyroid and Parathyroid Surgery
- Anesthesia and Neurotoxicity Research
- Antibiotics Pharmacokinetics and Efficacy
- Opioid Use Disorder Treatment
- Veterinary Medicine and Surgery
- Toxin Mechanisms and Immunotoxins
- Neuroendocrine Tumor Research Advances
- Liver Disease Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Electrolyte and hormonal disorders
- Traditional Chinese Medicine Studies
- Hemostasis and retained surgical items
- Pediatric Hepatobiliary Diseases and Treatments
- Artificial Intelligence in Healthcare
Universitat Autònoma de Barcelona
2015-2024
Universitat Pompeu Fabra
2017
Universitat de Barcelona
2014
Centre for Research on Ecology and Forestry Applications
2011
Computer Vision Center
2010
Queen's University Belfast
2007
For most lysosomal storage diseases (LSDs) affecting the CNS, there is currently no cure. The BBB, which limits bioavailability of drugs administered systemically, and short half-life enzymes, hamper development effective therapies. Mucopolysaccharidosis type IIIA (MPS IIIA) an autosomic recessive LSD caused by a deficiency in sulfamidase, sulfatase involved stepwise degradation glycosaminoglycan (GAG) heparan sulfate. Here, we demonstrate that intracerebrospinal fluid (intra-CSF)...
Diabetes is associated with severe secondary complications, largely caused by poor glycemic control. Treatment exogenous insulin fails to prevent these complications completely, leading significant morbidity and mortality. We previously demonstrated that it possible generate a "glucose sensor" in skeletal muscle through coexpression of glucokinase insulin, increasing glucose uptake correcting hyperglycemia diabetic mice. Here, we demonstrate long-term efficacy this approach large animal...
Abstract Objective To investigate the diagnostic and prognostic value over time of plasma iron compared with inflammatory markers albumin, C‐reactive protein (CRP), fibrinogen in dogs systemic response syndrome (SIRS). Design Prospective observational study sequentially enrolled dogs. Setting ICU a veterinary teaching hospital. Animals One hundred sixteen client‐owned dogs: 54 SIRS or sepsis, 42 focal inflammation, 20 clinically healthy Measurements Main Results Blood samples were obtained...
The "One world, one health" initiative emphasizes the need for new strategies to control human and animal tuberculosis (TB) based on their shared interface. A good example would be development of novel universal vaccines against Mycobacterium complex (MTBC) infection. This study uses goat model, a natural TB host, assess protective effectiveness vaccine candidate in combination with Bacillus Calmette-Guerin (BCG) vaccine. Thirty-three kids were divided three groups: Group 1) vaccinated BCG...
Delivery of adeno-associated viral vectors (AAVs) to cerebrospinal fluid (CSF) has emerged as a promising approach achieve widespread transduction the central nervous system (CNS) and peripheral (PNS), with direct applicability treatment wide range neurological diseases, particularly lysosomal storage diseases. Although studies in small animal models have provided proof concept experiments large animals demonstrated feasibility bigger brains, there is not much information on long-term safety...
The purpose of this randomised trial was to compare the effects alfaxalone and propofol on tear production (STT‐1), intraocular pressure (IOP) globe position (GP) in healthy dogs. Fourteen Beagles were randomly divided into two groups; dogs one group received (3 mg/kg) (n=7) other (6 (n=7), both administered intravenously. IOP GP evaluated at basal time (T b ) T 2,5,10,15,20,25&30 (minutes after complete drug administration). STT‐1 10,20&30 . results analysed using analysis variance...
Abstract Irreversible electroporation is a fast-growing liver ablation technique. Although safety has been well documented in small ablations, our aim to assess its and feasibility when large portion of ablated. Eighty-seven mice were subjected high voltage pulses directly delivered across parallel plate electrodes comprising around 40% mouse liver. One group consisted 55 athymic-nude, which tumor from the KM12C cell line was grown other thirty-two C57-Bl6 non-tumoral mice. Both groups...
To improve the computer modelling of radiofrequency ablation (RFA) by internally cooled wet (ICW) electrodes with added clinically oriented features.An improved RFA model ICW electrode included: (1) a realistic spatial distribution infused saline, and (2) different domains to distinguish between healthy tissue, saline-infused tumour, non-infused under assumption that saline is retained within tumour boundary. A was obtained from an in vivo pig liver study. The results were analysed terms...
The objective of this prospective study was to determine the effects a single intravenous bolus alfaxalone in 2-hydroxypropyl-β-cyclodextrin and propofol on intraocular pressure (IOP) sheep. Ten Ripollesa sheep with bodyweight 48.5 (6.8) kg (mean [sd]) were used study. Twenty-four hours before experimental procedure, complete ophthalmic examination performed all animals. day study, (2 mg/kg) or (6 randomly administered cross-over design, washout period two weeks. Measurements IOP, globe...
The objective of the present study was to evaluate plasma concentrations and pharmacokinetics buprenorphine after transdermal application in dogs (n = 4). A 70 microg/h patch applied ventral abdomen four healthy beagles. Blood samples were collected through a preplaced jugular catheter before at 1, 2, 4, 8, 12, 24, 36, 48 every 6 h until 108 application. Plasma measured using (125)I-labelled radioimmunoassay (RIA) assay. No adverse effects observed any dogs. Concentrations detected on...
Purpose: To assess by means of computer simulations whether the heat sink effect inside a large vessel (portal vein) could protect wall from thermal damage close to an internally cooled electrode during radiofrequency (RF)‐assisted resection. Methods: First, in vivo experiments were conducted validate computational model comparing experimental and lesion shapes created around vessels. Computer then carried out study different factors such as device‐tissue contact, position, vessel‐device...
To evaluate the impact of using monopolar thermal coagulation based on radiofrequency (RF) currents intraoperative blood loss during liver resection.A prospective randomised controlled trial was planned. Patients undergoing hepatectomy were into two groups. In control group (n = 10), hemostasis obtained with a combination stitches, vessel-sealing bipolar RF systems, sutures or clips. (MRFC) 18), mainly an internally cooled electrode.No differences in demographic clinical characteristics...
Gene therapy may provide new treatments for severe pancreatic disorders. However, gene transfer to the pancreas is difficult because of its anatomic location and structure, pancreatitis a serious concern. Like human pancreas, canine compact, with similar vascularization lobular structure. It therefore suitable model in which assess strategies. Here we examined ability adenoviral vectors genes into dogs circulation had been clamped. Adenoviruses carrying β-galactosidase (β-gal) were injected...
Porcine circovirus type 2 (PCV2) is the causative agent of postweaning multisystemic wasting syndrome (PMWS). The presence immunostimulating factors or concurrent infections seems to be crucial for PMWS development. Lipopolysaccharide (LPS) a potent immunological activator and has recently been suggested enhance PCV2 replication in vitro. This study was designed evaluate effects different LPS products on vitro pulmonary macrophages (PMs), potential ability trigger cesarean-derived,...