A5083636372- Synthesis and Catalytic Reactions
- Chemical synthesis and alkaloids
- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Advanced Synthetic Organic Chemistry
- Asymmetric Hydrogenation and Catalysis
- Axial and Atropisomeric Chirality Synthesis
- Synthesis of β-Lactam Compounds
- Chemical Synthesis and Analysis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Sulfur-Based Synthesis Techniques
University of Vienna
2024
Sapienza University of Rome
2018-2022
Abstract The organocatalyzed addition of several malonates to 1,4‐benzoquinones affords benzofuranones bearing a quaternary stereocenter with good enantioselectivity. This reaction is an intramolecular desymmetrization since it proceeds through the formation arylated achiral malonate that cyclizes give product. rate quinone dramatically affects yield which was originally low. considerably increased, in some cases, from less than 20 % over 95 %, by adding portions rather at once, keeping...
Abstract Sulfenyl imidinium salts are a virtually unexplored class of intermediates in organic chemistry. Herein, we demonstrate how sulfonium rearrangements can be deployed to access these versatile synthetic intermediates, bearing three contiguous (and congested) stereogenic centers, with high levels selectivity. The value the scaffold was unraveled by selective transformations into range building blocks, including 1,4‐dicarbonyl derivatives and sulfonolactones.
An aggregation phenomenon involving <italic>Cinchona</italic> alkaloid derivatives deeply affects the performance of catalyst in an organocatalytic process – a mechanistic study.
Benzazetidines are highly strained and inherently unstable heterocycles. There only few methodologies for assembling these compounds. Here, a protocol is presented to trap an elusive cyclic, four-membered hemiaminal structure. This method affords several benzazetidines in moderate good yields (up 81%), it uses inexpensive materials does not require catalysts based on transition metals. The high ring strain energy of benzazetidine systems was estimated by density functional theory...
Abstract Sulfenyl imidinium salts are a virtually unexplored class of intermediates in organic chemistry. Herein, we demonstrate how sulfonium rearrangements can be deployed to access these versatile synthetic intermediates, bearing three contiguous (and congested) stereogenic centers, with high levels selectivity. The value the scaffold was unraveled by selective transformations into range building blocks, including 1,4‐dicarbonyl derivatives and sulfonolactones.
Abstract 4‐dimethylaminopyridine (DMAP) is an extremely versatile catalyst active in a large series of chemical transformations because its relevant basicity and nucleophilicity. In this paper, we present the synthesis two chiral DMAP derivatives starting from 4‐halopyridine l ‐proline benzyl ester. The key steps these preparations are Zn II ‐coordinated dimer proline ester variation Buchwald‐Hartwig promoted by copper(I) salts. preparation compounds was achieved with use inexpensive...