A5100333418- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Hereditary Neurological Disorders
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Neurological disorders and treatments
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Botulinum Toxin and Related Neurological Disorders
- Epilepsy research and treatment
- Stress Responses and Cortisol
- Genomics and Rare Diseases
- Pain Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Pregnancy and preeclampsia studies
- Cancer, Stress, Anesthesia, and Immune Response
- Tryptophan and brain disorders
- Music Therapy and Health
- Gestational Diabetes Research and Management
- Communication in Education and Healthcare
- Ion channel regulation and function
- Neurological diseases and metabolism
- Axon Guidance and Neuronal Signaling
- Ergonomics and Musculoskeletal Disorders
- Memory and Neural Mechanisms
Peking University
2021-2025
Peking University Third Hospital
2021-2025
Shanghai Jiao Tong University
2015-2025
International Peace Maternity & Child Health Hospital
2020-2025
Minzu University of China
2019-2025
Guangzhou Medical University
2023-2024
Tongji University
2020-2023
Tongji Hospital
2020-2023
Research Institute of Subtropical Foresty
2023
Qufu Normal University
2023
Traditional assessments of public speaking skills rely on human scoring. We report an initial study the development automated scoring model for performances using multimodal technologies. Task design, rubric development, and rating were conducted according to standards in educational assessment. An corpus 17 speakers with 4 tasks was collected audio, video, 3D motion capturing devices. A based basic features speech content, delivery, hand, body, head movements significantly predicts rating,...
Depression is the most prevalent psychiatric disorder worldwide and remains incurable; however, there little research on its prevention. The leading cause of depression stress, music has been hypothesized to alleviate stress. To examine potential beneficial effects stress depression, we subjected mice chronic unpredictable mild (CUMS) during day at night. Strikingly, our results indicated that completely prevented CUMS-induced anxiety-like behaviors in mice, as assessed by open field, tail...
Addressing the urgent need for innovative depression treatments, this study heralds a breakthrough in major depressive disorder (MDD) therapy by intertwining clinical observations with neurobiological advancements. We analyzed brain-derived neurotrophic factor (BDNF) levels serum exosomes from diverse group of 60 individuals, including first-episode, drug-free MDD patients, medicated and healthy controls. Our results revealed significant decrease BDNF within patients’ exosomes, which notably...
Charcot-Marie-Tooth (CMT) neuropathies represent a heterogeneous group of peripheral nerve disorders affecting 1 in 2,500 persons. One variant, CMT1A, is primary Schwann cell (SC) disorder, and represents the single most common variant. In previous studies, we showed that neurotrophin-3 (NT-3) improved trembler(J) (Tr(J)) mouse also efficacy CMT1A patients. Long-term treatment with NT-3 was not possible related to its short half-life lack availability. This led considerations gene therapy...
Abstract There is an increasing risk of mental disorders, such as acute stress disorder (ASD), post-traumatic (PTSD) and depression among survivors who were trapped in rubble during earthquake. Such long-term impaction a single restraint has not been extensively explored. In this study, we subjected mice to 24-hour-restraint simulate the trapping episode, investigated (2 days after restraint) (35 impacts. Surprisingly, found that displayed depression-like behaviors, decreased glucose uptake...
Abstract Background Previous studies have focused on pregnancy outcomes after frozen embryo transfer (FET) performed using different endometrial preparation protocols. Few evaluated the effect of pregnancy-related complications. This study was designed to explore association between protocols and adverse obstetric perinatal complications FET. Methods We retrospectively included all FET cycles ( n = 12,950) in our hospital 2010 2017, categorized them into three groups, natural (NC), hormone...
The Asian citrus psyllid, Diaphorina citri is the principal vector of highly destructive disease called Huanglongbing (HLB) or greening, which a major threat to cultivation worldwide. More effective pest control strategies against this entail identification potential chemosensory proteins that could be used in development attractants repellents. However, molecular basis olfaction psyllid not completely understood. Therefore, we performed study analyze antennal and abdominal transcriptome...
As the popularity of video-based job interviews rises, so does need for automated tools to evaluate interview performance. Real world hiring decisions are based on assessments knowledge and skills as well holistic judgments person-job fit. While previous research scoring videos shows promise, it lacks coverage monologue-style responses structured (SI) questions content-focused rating. We report development a standardized video protocol human rating rubrics focusing verbal content,...
Abstract X-linked Charcot-Marie-Tooth neuropathy (CMTX) is caused by mutations in the gene encoding Gap Junction Protein Beta-1 (GJB1)/Connexin32 (Cx32) Schwann cells. Neurotrophin-3 (NT-3) an important autocrine factor supporting cell survival and differentiation stimulating axon regeneration myelination. Improvements these parameters have been shown previously a CMT1 model, Trembler J mouse, with NT-3 transfer therapy. For this study, scAAV1.tMCK.NT-3 was delivered to gastrocnemius muscle...
Bile acids play essential roles in metabolic modulation. Excessive serum total bile acid (sTBA) levels during pregnancy are associated with adverse perinatal outcomes; however, their association the risk of intrauterine growth restriction (IUGR) remains unclear.To investigate between maternal sTBA concentration and IUGR.This retrospective cohort study included pregnant individuals who delivered live singleton neonates had regular antenatal examination records available at a hospital-based...
Delayed neurocognitive recovery (dNCR) is a common postoperative complication in geriatric surgical patients for which there no efficacious therapy. Cholecystokinin octapeptide (CCK-8), an immunomodulatory peptide, regulates memory and learning. Here, we explored the effects mechanism of action CCK-8 on dNCR.We applied laparotomy to establish model dNCR aged mice. Morris water maze fear conditioning tests were used evaluate cognition. Immunofluorescence was detect density CCK-8, A1 reactive...
The X-linked form of Charcot-Marie-Tooth neuropathy is associated with mutations in the connexin32 (Cx32) gene. functional role Cx32 Schwann cells and relationship these to progressive axonal loss distal limb weakness seen this disease have not been elucidated. To investigate local influence bearing gene defect on cytoskeleton myelination process, nerve xenograft model was used transfer a missense mutation (Glu102Gly) from human an vivo system nude mice. Twelve grafts two family members 17...
X-Linked Charcot-Marie-Tooth disease is an inherited peripheral neuropathy arising in patients with mutations the gene encoding connexin 32 (Cx32). Cx32 expressed at paranodes and Schmidt-Lantermann incisures of myelinating Schwann cells which it believed to form a reflexive pathway between abaxonal adaxonal cytoplasmic domains. Patients Val181Ala (V181A) mutation have severe neuropathy. Experiments using nude mouse xenograft system show that expressing only this mutant are profoundly...
Postherpetic neuralgia (PHN), the most common complication of herpes zoster (HZ), plays a major role in decreased life quality HZ patients. However, neural mechanisms underlying PHN remain unclear. Here, using rat model at 2 weeks after varicella virus infection, we found that spinal astrocytes were dramatically activated. The mechanical allodynia and central sensitization significantly attenuated by intrathecally injected L-α-aminoadipate (astrocytic specific inhibitor) whereas minocycline...
Glycyl-tRNA synthetase mutations are associated to the Charcot-Marie-Tooth disease type-2D. The GarsP278KY/+ model for type-2D is known best its early onset severe neuropathic phenotype with findings including reduced axon size, slow conduction velocities and abnormal neuromuscular junction. Muscle involvement remains largely unexamined. We tested efficacy of neurotrophin 3 gene transfer therapy in two Gars mutants (GarsP278KY/+ ) milder (GarsΔETAQ/+ phenotypes via intramuscular injection...
Objective Hundreds of countries have implemented lockdown policies to slow the spread coronavirus disease-2019 (COVID-19), but impact these measures on maternal mental health is not well understood.Methods This study integrated a stress-process model examine pathways from lockdown-related stressors prenatal psychological outcomes, with COVID-19 coping strategies (COP) and self-efficacy in managing negative affect (NEG) as mediators duration, hours pandemic-related information, number...
ABSTRACT Aims Developing validated treatments for Parkinson's disease (PD) remains a priority clinicians and researchers. The lack of viable therapies may stem from an incomplete understanding PD pathogenesis inadequate therapeutic candidates. production transmission exosomes are gaining recognition in the neurodegenerative diseases. However, how affect pathophysiology has not been well elucidated. Methods Here, we investigated effect secreted by rats that were treated with saline or...
Abstract The inhibitory amino acid γ‐aminobutyric (GABA) is the major neurotransmitter in globus pallidus. Although electrophysiological studies have indicated that functional GABA B receptors exist rat pallidus, subcellular localization of receptor subunits and their spatial relationship to glutamatergic GABAergic synapses are unknown. Here, we use pre‐embedding immunogold labeling study subunits, B1 B2 , pallidus neurons identified populations afferent terminals. Immunolabeling for was...
Abstract Bone cancer pain has been reported to have unique mechanisms and is resistant morphine treatment. Recent studies indicated that neuron-restrictive silencer factor (NRSF) plays a crucial role in modulating the expression of μ-opioid receptor (MOR) gene. The present study elucidates regulatory MOR its ability affect bone pain. Using sarcoma-inoculated murine model, behaviors represent continuous or breakthrough were evaluated. Expression NRSF dorsal root ganglion (DRG) spinal horn was...