A5052246917- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Dietary Effects on Health
- Cancer Genomics and Diagnostics
- Monoclonal and Polyclonal Antibodies Research
- Aortic Disease and Treatment Approaches
- Cancer, Hypoxia, and Metabolism
- Trauma and Emergency Care Studies
- Adrenal and Paraganglionic Tumors
- Hedgehog Signaling Pathway Studies
- T-cell and B-cell Immunology
- Abdominal vascular conditions and treatments
- Liver Disease and Transplantation
- Cancer and Skin Lesions
- Pituitary Gland Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Nonmelanoma Skin Cancer Studies
- Immune cells in cancer
- Trauma Management and Diagnosis
- Vascular anomalies and interventions
- Liver Disease Diagnosis and Treatment
Virginia Commonwealth University
2013-2020
University of Tennessee Health Science Center
2020
University Health System
2020
National Institutes of Health
2016
National Cancer Institute
2015-2016
Abstract Adoptive transfer of T cells with engineered T-cell receptor (TCR) genes that target tumor-specific antigens can mediate cancer regression. Accumulating evidence suggests the clinical success many immunotherapies is mediated by targeting mutated neoantigens unique to patient. We hypothesized most frequent TCR clonotypes infiltrating tumor were reactive against antigens. To test this hypothesis, we developed a multistep strategy involved TCRB deep sequencing CD8+PD-1+ subset,...
Patients with von Hippel-Lindau (VHL) syndrome have a 25-30% chance of developing pheochromocytoma. Although practice guidelines recommend biochemical and radiological screening every 1-2 years for pheochromocytoma in patients VHL, there are limited data on the optimal age frequency screening.Our objective was to determine earliest onset contralateral recurrent pheochromocytomas VHL syndrome.This is retrospective analysis prospective cohort enrolled natural history study.A total 273...
Mammary Paget's disease is a rare form of breast neoplasm that often presents with pruritic eczema-like rash involving the nipple-areolar complex, and refractory to common remedies. It associated underlying cancer, sometimes difficult diagnose. In this review, we present an update approach its surgical treatment.
Hepatic artery aneurysms are rare, but their diagnosis is important because of high mortality and complications. Common risk factors for developing these include hypertension, vascular disease, pancreatitis, diabetes, tobacco use, autoimmune diseases, previous transplantation. Frequent imaging trauma tumor surveillance has increased the incidence naive hepatic aneurysms. These can be difficult to manage, it challenging decide correct treatment modality patient. Hereby, we present four cases...
Adoptive transfer of T-cell receptor (TCR) gene engineered T-cells targeting tumor-associated antigens can mediate cancer regression. Accumulating evidence suggests that the clinical success many immunotherapies is mediated by mutated neoantigens unique to patient. We hypothesized most frequent TCR clonotypes infiltrating tumor were reactive against antigens. thus developed a multi-step strategy involved CDR3-TCRB deep sequencing lymphocytes and matching TCRA-TCRB pairs pairSEQ single cell...
<div>Abstract<p>Adoptive transfer of T cells with engineered T-cell receptor (TCR) genes that target tumor-specific antigens can mediate cancer regression. Accumulating evidence suggests the clinical success many immunotherapies is mediated by targeting mutated neoantigens unique to patient. We hypothesized most frequent TCR clonotypes infiltrating tumor were reactive against antigens. To test this hypothesis, we developed a multistep strategy involved TCRB deep sequencing...
<div>Abstract<p>Adoptive transfer of T cells with engineered T-cell receptor (TCR) genes that target tumor-specific antigens can mediate cancer regression. Accumulating evidence suggests the clinical success many immunotherapies is mediated by targeting mutated neoantigens unique to patient. We hypothesized most frequent TCR clonotypes infiltrating tumor were reactive against antigens. To test this hypothesis, we developed a multistep strategy involved TCRB deep sequencing...
© Translational Cancer Research. All rights reserved. tcr.amegroups.com Transl Res 2017 The incidence of hepatocellular cancer (HCC) has been steadily increasing in the United States for last several decades, and currently HCC constitutes fastest growing cause deaths country. majority occurs setting chronic liver disease with viral infections [hepatitis B virus (HBV) or hepatitis C (HCV)] alcohol-related being most common risk factors. Recently non-alcoholic fatty (NAFLD) steatohepatitis...
Abstract Background: Adoptive transfer of tumor infiltrating lymphocytes (TIL) can effect long-term durable regression in patients with metastatic melanoma but has not been widely tested common epithelial cancers. Similar to melanoma, recent studies on GI cancers report that regressions be mediated by adoptively transferred TIL recognizing non-synonymous somatic mutations. Breast cancer tumors are infiltrated and reactivity against autologous mutations identified. Methods: were grown from a...
764 Background: Pancreatic Ductal Adenocarcinoma (PDAC) has less than a 10% five year survival and will become the second leading cause of US cancer mortality in next decade. Immunotherapy, such as checkpoint inhibition against anti-Programmed death-ligand 1 (PD-L1) not been successful treatment PDAC patients. Both tumor associated macrophages (TAMs) TGF-β protein are ubiquitous tumors. We hypothesize that increases overall number TAMs degree PD-L1 expression PDAC. Methods: Our lab mouse...