A5082190027- Advanced Chemical Sensor Technologies
- Air Quality and Health Impacts
- Air Quality Monitoring and Forecasting
- Metabolomics and Mass Spectrometry Studies
- Health, Environment, Cognitive Aging
- Analytical Chemistry and Chromatography
- Indoor Air Quality and Microbial Exposure
- Toxic Organic Pollutants Impact
- Occupational Health and Performance
- Effects and risks of endocrine disrupting chemicals
- Mass Spectrometry Techniques and Applications
- Carcinogens and Genotoxicity Assessment
- Olfactory and Sensory Function Studies
- Vehicle emissions and performance
- Atmospheric chemistry and aerosols
- Injury Epidemiology and Prevention
- Biosensors and Analytical Detection
- Insect Pheromone Research and Control
- Biochemical Analysis and Sensing Techniques
- Nutritional Studies and Diet
- Odor and Emission Control Technologies
- Climate Change and Health Impacts
- Spectroscopy and Laser Applications
- Energy and Environment Impacts
- Fire dynamics and safety research
University of North Carolina at Chapel Hill
2004-2024
Environmental Protection Agency
2011-2020
Research Triangle Park Foundation
2011-2020
National Center for Environmental Assessment (EPA)
2007
Battelle
1995
Environmental Protection Agency
1990
Southern Illinois University Carbondale
1979-1980
non-parametric sign tests and Spearman tests, respectively.We found significantly elevated (P < 0.05) post-exposure breath concentrations of benzene compared with pre-exposure for both rounds.We also levels PAHs on the neck round 1.We statistically significant positive correlations between external exposures (i.e.personal air PAHs) biomarkers (i.e.change in urinary PAH metabolite 1 change 2).The results suggest that firefighters wearing full protective ensembles absorbed combustion products...
Volatile organic compounds (VOCs) in exhaled breath originate from current or previous environmental exposures (exogenous compounds) and internal metabolic (anabolic catabolic) production (endogenous compounds). The origins of certain VOCs presumed to be endogenous have been proposed useful as preclinical biomarkers various undiagnosed diseases including lung cancer, breast cardio-pulmonary disease. usual approach is develop difference algorithms comparing VOC profiles nominally healthy...
Abstract To better understand the absorption of combustion byproducts during firefighting, we performed biological monitoring (breath and urine) on firefighters who responded to controlled residential fires examined results by job assignment fire attack tactic. Urine was analyzed for metabolites polycyclic aromatic hydrocarbons (PAHs) breath volatile organic compounds (VOCs) including benzene. Median concentrations PAH in urine increased from pre-firefighting 3-h post firefighting all...
Firefighters' personal protective equipment (PPE) ensembles will become contaminated with various compounds during firefighting. Some of these off-gas following a response, which could result in inhalation exposure. This study was conducted to determine the magnitude and composition volatile organic (VOCs) generated controlled structure burns that subsequently off-gassed from firefighters' PPE, were systemically absorbed exhaled breath. Three crews five firefighters performed entry,...
Human biomonitoring is the foundation of environmental toxicology, community public health evaluation, preclinical effects assessments, pharmacological drug development and testing, medical diagnostics. Within this framework, intra-class correlation coefficient (ICC) serves as an important tool for gaining insight into human variability responses developing risk-based assessments in face sparse or highly complex measurement data. The analytical procedures that provide data clinical efforts...
Training fires may constitute a major portion of some firefighters' occupational exposures to smoke. However, the magnitude and composition those are not well understood vary by type training scenario fuels.To understand how structure fire contributes instructors' select chemical exposures, we conducted biological monitoring during exercises involving combustion pallet straw oriented strand board (OSB) or use simulated smoke.Urine was analyzed for metabolites polycyclic aromatic hydrocarbons...
JP-8 jet fuel (similar to commercial/international A-1 fuel) is the standard military for all types of vehicles, including U.S. Air Force aircraft inventory. As such, presents most common chemical exposure in Force, particularly flight and ground crew personnel during preflight operations maintenance performing routine tasks. Personal at an base occurs through occupational involved with handling and/or incidental exposure, primarily inhalation ambient vapors. Because less volatile than its...
Abstract The organic constituents of exhaled human breath are representative blood-borne concentrations through gas exchange in the blood/breath interface lungs. presence specific compounds can be an indicator recent exposure or represent a biological response subject. For volatile (VOCs), sampling and analysis is preferred to direct measurement from blood samples because collection noninvasive, potentially infectious waste avoided, gas-phase analytes much simpler matrix rather than complex...
ADVERTISEMENT RETURN TO ISSUEPREVFeatureNEXTEvolution of Environmental Exposure Science: Using Breath-Borne Biomarkers for "Discovery" the Human ExposomeAccording to recent research, 70−90% long-term latency and chronic human disease incidence is attributable environmental (human exposome) factors through gene−environment interaction. exposure science now embarking on a new "discovery" path decoding exposome using biomarkers in breath other biological media.Joachim D. Pleil*† Matthew A....
Epidemiological observations of urban inhalation exposures to diesel exhaust (DE) and ozone (O3) have shown pre-clinical cardiopulmonary responses in humans. Identifying the key biological mechanisms that initiate these health bioindicators is difficult due variability environmental exposure time from person person. Previously, environmentally controlled human chambers been used study DE O3 dose-response patterns separately, but investigation co-exposures has not performed under conditions....
Alveolar breath sampling was used to assess trihalomethane (THM) exposures encountered by collegiate swimmers during a typical 2-hr training period in an indoor natatorium. The samples were collected at regular intervals before, during, and for 3 hr after moderately intense workout. Integrated grab whole-air the help determine inhalation exposures, pool water dermal exposures. Resulting workout demonstrated rapid uptake of two THMs (chloroform bromodichloromethane), with chloroform...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMethod development and field measurements for polar volatile organic compounds in ambient airThomas J. Kelly, Patrick Callahan, Joachim Pleil, Gary F. EvansCite this: Environ. Sci. Technol. 1993, 27, 6, 1146–1153Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/es00043a014https://doi.org/10.1021/es00043a014research-articleACS PublicationsRequest reuse...
The availability of reliable, accurate and precise monitoring methods for toxic volatile organic compounds (VOCs) is a primary need state local agencies addressing daily requirements related to odor complaints, fugitive emissions, trend monitoring. canister-based method VOCs viable widely used approach that based on research evaluation performed over the past several years. This activity has involved testing sample stability in canisters design time-integrative samplers. development...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCorrection-Automated Cryogenic Preconcentration and Gas Chromatographic Determination of Volatile Organic Compounds in AirWilliam A. McClenny, Joachim D. Pleil, Michael W. Holdren, Richard N. SmithCite this: Anal. Chem. 1985, 57, 6, 1168Publication Date (Print):May 1, 1985Publication History Published online16 October 2002Published inissue 1 May 1985https://pubs.acs.org/doi/10.1021/ac00283a601https://doi.org/10.1021/ac00283a601research-articleACS...