A5061081002- Cerebral Venous Sinus Thrombosis
- Mitochondrial Function and Pathology
- Machine Learning in Materials Science
- Neurosurgical Procedures and Complications
- Computational Drug Discovery Methods
- ATP Synthase and ATPases Research
- Retinal Development and Disorders
- Head and Neck Surgical Oncology
- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- Advanced Graph Neural Networks
- Vascular Malformations and Hemangiomas
- Vascular Tumors and Angiosarcomas
- Ocular Oncology and Treatments
- Retinal Diseases and Treatments
- Photosynthetic Processes and Mechanisms
- Advanced Fluorescence Microscopy Techniques
- Retinal and Optic Conditions
- Sarcoma Diagnosis and Treatment
- Cervical and Thoracic Myelopathy
- Neurological disorders and treatments
- Pituitary Gland Disorders and Treatments
- Cerebrovascular and genetic disorders
- Multiple Sclerosis Research Studies
- Topic Modeling
MRC Mitochondrial Biology Unit
2021-2024
University of Cambridge
2021-2024
Addenbrooke's Hospital
2021-2024
University of Auckland
2011-2024
ORCID
2023
Emory University
2019-2022
University of California, San Diego
2018-2022
Cambridge University Hospitals NHS Foundation Trust
2022
Auckland City Hospital
2017-2021
Emory Eye Center
2020-2021
Rationale: Less invasive, nonsurgical approaches are needed to treat severe emphysema.Objectives: To evaluate the effectiveness and safety of Spiration Valve System (SVS) versus optimal medical management.Methods: In this multicenter, open-label, randomized, controlled trial, subjects aged 40 years or older with severe, heterogeneous emphysema were randomized 2:1 SVS management (treatment) alone (control).Measurements Main Results: The primary efficacy outcome was difference in mean FEV1...
Previously we have shown that thioamides can be incorporated into proteins as minimally perturbing fluorescence-quenching probes to study protein dynamics, folding, and aggregation. Here, show the spontaneity of photoinduced electron transfer between a thioamide an excited fluorophore is governed by redox potentials each moiety according Rehm–Weller-type model. We used this model predict quenching various common fluorophores, rigorously tested more than dozen examples. In case, found...
<h3>Importance</h3> Magnetic resonance imaging (MRI) signs of intracranial hypertension (IH) are traditionally associated with idiopathic (IIH), but these also detected among individuals primary headaches and asymptomatic without papilledema. <h3>Objective</h3> To examine the prevalence MRI IH consecutive outpatients undergoing brain for any clinical indication to explore their association <h3>Design, Setting, Participants</h3> This prospective cross-sectional study at 1 outpatient facility...
We propose a new model for making generalizable and diverse retrosynthetic reaction predictions. Given target compound, the task is to predict likely chemical reactants produce target. This generative can be framed as sequence-to-sequence problem by using SMILES representations of molecules. Building on top popular Transformer architecture, we two novel pre-training methods that construct relevant auxiliary tasks (plausible reactions) our problem. Furthermore, incorporate discrete latent...
Abstract Epidemiological evidence that red wine consumption negatively correlates with risk of Alzheimer's disease has led to experimental studies demonstrating grape seed extracts inhibit the aggregation and oligomerization Aβ in vitro ameliorate neuropathology behavioral deficits a mouse model disease. The active agent is mixed population polyphenolic compounds. To evaluate relative potency each these compounds, HPLC was used fractionate mixture into monomers, dimers, oligomers. Each...
<div>Much of the recent work on learning molecular representations has been based Graph Convolution Networks (GCN). These models rely local aggregation operations and can therefore miss higher-order graph properties. To remedy this, we propose Path-Augmented Transformer (PAGTN) that are explicitly built longer-range dependencies in graphstructured data. Specifically, use path features graphs to create global attention layers. We compare our PAGTN model against GCN show...
Background: Leber hereditary optic neuropathy (LHON) is an inherited mitochondrial disease characterized by severe bilateral vision loss and chronic visual impairment. The objective of this study was to comprehensively explore the impact LHON on lives patients their relatives at time diagnosis now. Methods: Qualitative design with 8 focus group interviews conducted in France, Germany, United Kingdom, States, involving 17 individuals m.11778G>A mutation relatives. Separate groups for were...
Much of the recent work on learning molecular representations has been based Graph Convolution Networks (GCN). These models rely local aggregation operations and can therefore miss higher-order graph properties. To remedy this, we propose Path-Augmented Transformer (PAGTN) that are explicitly built longer-range dependencies in graph-structured data. Specifically, use path features graphs to create global attention layers. We compare our PAGTN model against GCN show consistently outperforms...
Current graph neural network (GNN) architectures naively average or sum node embeddings into an aggregated representation -- potentially losing structural semantic information. We here introduce OT-GNN, a model that computes using parametric prototypes highlight key facets of different aspects. Towards this goal, we successfully combine optimal transport (OT) with models. Graph representations are obtained from Wasserstein distances between the set GNN and ``prototype'' point clouds as free...
Background: Radiologic findings of intracranial hypertension (RAD-IH) are common in idiopathic (IIH) patients. Paralleling the increasing rates obesity, burden IIH is growing. Urgent neuro-ophthalmology consultations for possible patients with incidentally detected RAD-IH increasing, many receiving unnecessary lumbar punctures (LPs) and treatments. This retrospective observational study aimed to determine prevalence RAD-IH, rate funduscopic examination by referring providers, papilledema,...
A relationship between idiopathic intracranial hypertension and spontaneous skull base cerebrospinal fluid (CSF) leaks has been proposed, by which CSF leak decreases pressure (ICP) masks the symptoms signs of elevated ICP. These patients are at risk developing papilledema, ICP, or a recurrent after repair. The objective this study was to assess whether radiographic raised ICP on preoperative magnetic resonance computed venography (MRI CTV) predictors postoperative recurrence leak, need for...
One of the most promising approaches to delay, prevent or reverse disability progression in multiple sclerosis (MS) is enhance endogenous remyelination and limit axonal degeneration. In clinical trials remyelinating drugs, there a need for reliable, sensitive clinically relevant outcome measures. The visual pathway, which frequently affected by MS, provides unique model system evaluate acute chronic MS lesions vivo non-invasively. this review, we discuss different measures that have been...
Purpose of review Leber hereditary optic neuropathy (LHON) is a mitochondrial DNA disease characterised by sequential bilateral vision loss due to retinal ganglion cells. The purpose this provide an update on the results recent clinical trials for LHON, focusing studies idebenone and lenadogene nolparvovec gene therapy. Recent findings Evidence from three (RHODOS, RHODOS-OFU, LEROS) suggest that should be started early continued at least 24 months. Treatment effect varies according stage...