A5052227712- Renal Diseases and Glomerulopathies
- Organic Electronics and Photovoltaics
- Conducting polymers and applications
- Chronic Kidney Disease and Diabetes
- Genetic and Kidney Cyst Diseases
- Perovskite Materials and Applications
- Molecular Junctions and Nanostructures
- Biomedical Research and Pathophysiology
- Cellular transport and secretion
- Lipoproteins and Cardiovascular Health
- Fullerene Chemistry and Applications
- Ophthalmology and Eye Disorders
- Pancreatic function and diabetes
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Renal and related cancers
- Nasolacrimal Duct Obstruction Treatments
- Atherosclerosis and Cardiovascular Diseases
- Acute Kidney Injury Research
- Mobile Crowdsensing and Crowdsourcing
- Nitric Oxide and Endothelin Effects
- Celiac Disease Research and Management
- Ginseng Biological Effects and Applications
- Caveolin-1 and cellular processes
- IgG4-Related and Inflammatory Diseases
University of Iowa
2020-2025
Xuzhou University of Technology
2020-2025
Fudan University
2018-2023
Fudan University Shanghai Cancer Center
2023
Eye & ENT Hospital of Fudan University
2022
Shanghai Jiao Tong University
2007-2021
University of Iowa Stead Family Children’s Hospital
2014-2021
Shanghai Ninth People's Hospital
2021
Beth Israel Deaconess Medical Center
2011-2020
Harvard University
2011-2020
A perylenediimide-based (PDI-based) small molecular (SM) acceptor with both an extended π-conjugation and a three-dimensional structure concurrently is critical for achieving high-performance PDI-based fullerene-free organic solar cells (OSCs). Herein, novel SM has been successfully synthesized through fusing PDI units spiro core 4,4'-spirobi[cyclopenta[2,1-b;3,4-b']dithiophene (SCPDT) together via β-position coupling thiophene bridges. An enhanced absorption from 350 to 520 nm observed....
Inverted formin 2 (INF2) encodes a member of the diaphanous subfamily proteins. Mutations in INF2 cause human kidney disease characterized by focal and segmental glomerulosclerosis. Disease-causing mutations occur only inhibitory domain (DID), suggesting specific roles for this pathogenesis disease. In yeast two-hybrid screen, we identified autoregulatory domains (DADs) mammalian diaphanous-related formins (mDias) mDia1, mDia2, mDia 3 as INF2_DID-interacting partners. The mDias are Rho...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) interacts directly with cytoplasmic apoB and prevents its degradation via the autophagosome/lysosome pathway. This process affects VLDL LDL production influences atherogenesis. Here, we investigated molecular machinery by which PCSK9 modulates autophagy We backcrossed
Acute kidney injury (AKI) is a common complication of critically ill adult patients with COVID-19. However, currently, no studies investigate impairment in children We investigated incidence and treatment AKI pediatric COVID-19 Wuhan Children's Hospital during the early stages pandemic discuss possible mechanisms related to SARS-CoV-2 infection.
Mutations in inverted formin 2 INF2 are a common cause of familial FSGS. interacts with diaphanous-related formins (mDia) and antagonizes mDia-mediated actin polymerization response to active Rho signaling, suggesting that dysregulation these pathways may mediate the development INF2-related However, precise mechanisms by which regulates actin-dependent podocyte behavior remain largely unknown. Here, we investigated possible role both lamellipodia-associated dynamics slit diaphragm (SD)...
Abstract Derived from perylenediimide (PDI) building blocks, 3D PDI molecules are considered as a type of promising structure to overcome molecular aggregation, thus improving the performance organic solar cells. Herein, we report novel PDI‐based derivative, SCPDT‐PDI 4 , with four units connected unique spiro core. Attributed this design, exhibits rigid structure, in which aggregation tendency chromophores could be effectively attenuated. Additionally, strong intramolecular charge transfer...
Background FSGS caused by mutations in INF2 is characterized a podocytopathy with mistrafficked nephrin, an essential component of the slit diaphragm. Because formin-type actin nucleator, research has focused on its actin-regulating function, providing important but incomplete insight into how these lead to podocytopathy. A yeast two-hybridization screen identified interaction between and dynein transport complex, suggesting newly recognized role regulating dynein-mediated vesicular...
Achieving ultrafast dissociation of photogenerated excitons and efficient charge transport within the photocatalyst is a fundamental issue. Additionally, enhancing interaction between semiconductors water crucial for photocatalytic splitting. Herein, we synthesized carboxylate‐based hydrophilic polymer, hPTB7‐Th. Exposed carboxylates enhance semiconductor‐water interfacial compatibility, reducing contact resistance accelerating transfer kinetics. Furthermore, carboxylate substitution shifts...
<i>Background:</i> Diabetic nephropathy (DN) is one of the most important microvascular complications diabetes mellitus. However, underlying mechanisms remain unclear. We studied expression characteristics angiopoietin-like 2 (ANGPTL2), a novel DN-associated growth factor identified in our previous gene chip screening. <i>Methods:</i> Glomeruli were microdissected from renal biopsies 24 patients with DN and 8 donor controls. The ANGPTL2 was assessed by RT-PCR...
Periodontitis is a highly prevalent infectious disease associated genetically with coronary heart (CHD). The effects of proprotein convertase subtilisin/kexin type 9 (PCSK9), critical regulator CHD, on periodontitis have not been studied to date. Here, we found that PCSK9 expression was increased in patients and Porphyromonas gingivalis (Pg)-infected mice. Loss attenuated Pg-induced periodontal bone loss First, deficiency reduced the release inflammation-associated cytokines, such as tumor...
Three-dimensional non-fullerene acceptors with a spiro core linked S/Se fused perylene diimides possess appropriate energy levels, twisted molecular configuration and high carrier mobility, leading to PCE of 6.95% for organic solar cells.
The incorporation of fluorine atoms in organic semiconducting materials has attracted much attention recently due to its unique function manipulate the molecular packing, film morphology and energy levels. In this work, two perylenediimide (PDI) derivatives FPDI-CDTph FPDI-CDTph2F were designed synthesized investigate impact fluorination on non-fullerene acceptors. Both exhibited strong broad absorption profiles, suitable lowest unoccupied orbital (LUMO) highest occupied (HOMO) levels, good...