A5006088615- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Glioma Diagnosis and Treatment
- Extracellular vesicles in disease
- Advanced Drug Delivery Systems
- Drug Transport and Resistance Mechanisms
- Inhalation and Respiratory Drug Delivery
- Cancer Research and Treatments
- Dendrimers and Hyperbranched Polymers
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antiplatelet Therapy and Cardiovascular Diseases
- Liver physiology and pathology
- Photodynamic Therapy Research Studies
- Immunotherapy and Immune Responses
- Protein Interaction Studies and Fluorescence Analysis
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Phagocytosis and Immune Regulation
- MicroRNA in disease regulation
- Atrial Fibrillation Management and Outcomes
- Natural Compounds in Disease Treatment
- Security and Verification in Computing
- Polysaccharides and Plant Cell Walls
Far Eastern Memorial Hospital
2023-2024
East China University of Science and Technology
2014-2024
Hong Kong University of Science and Technology
2024
University of Hong Kong
2024
University of North Carolina at Chapel Hill
2019-2021
Fudan University
2010-2016
Ministry of Education of the People's Republic of China
2011
Shanghai University of Traditional Chinese Medicine
2009
The design of bioresponsive controlled drug delivery systems is a promising approach in cancer therapy, but it still major challenge capable optimum therapeutic efficacy, i.e. no premature leakage blood circulation while having rapid and complete release tumor tissues. In this work, kind PEGylated core/shell structured composite nanoparticle was developed via precipitation polymerization, where disulfide-cross-linked poly(N-vinylcaprolactam-co-methacrylic acid) (P(VCL-s-s-MAA)) polymer shell...
Abstract: The aim of this work was to establish a novel polymeric mixed micelle composed Pluronic P105 and F127 copolymers loaded with the poorly soluble antitumor drug docetaxel (DTX) against Taxol-resistant non-small cell lung cancer. A central composite design utilized optimize preparation process, helping improve solubilization efficiency stability. Prepared by thin-film hydration method, average size optimized 23 nm, 92.40% encapsulation ratio 1.81% drug-loading efficiency. formulation...
Although photodynamic therapy (PDT) has been an attractive strategy for several cancer treatments in the clinical setting, PDT efficacy is attenuated by consumption of oxygen. To address this issue, we adopted a phototherapy-chemotherapy combination based on targeted delivery near-infrared photosensitizer indocyanine green (ICG), photothermal conversion agent polydopamine (PDA), and tirapazamine (TPZ), hypoxia-activated prodrug. Under laser irradiation, ICG oxygen aggravated hypoxia tumor...
Desmoplastic tumors are normally resistant to nanoparticle-based chemotherapy due dense stroma and limited particle permeability inside the tumor. Herein, we reported that hydralazine (HDZ)—an antihypertension vasodilator—would dramatically promote nanoparticle penetration in advanced desmoplastic tumors. First, a HDZ–liposome system was developed for tumor-selective delivery of HDZ. After three injections HDZ–liposomes at dose 15 mg/kg, tumor remarkably reduced, along with ameliorated...
The poor therapeutic efficacy of hydrophobic chemotherapeutic drugs is an intrinsic limitation to successful chemotherapy. In the present study, a multitask delivery system based on arginine-glycine-aspartic acid peptide (RGD) decorated vitamin E succinate (VES)-grafted-chitosan oligosaccharide (CSO)/RGD-conjugated d-alpha-tocopheryl polyethylene glycol 1000 (TPGS-RGD) mixed micelles (VeC/T-RGD MM) was first prepared for targeted anticancer drug, paclitaxel (PTX), improve U87MG tumor...
CLD/NIN@LIEV decreases the nonspecific phagocytosis of nanoparticles and suppresses inflammatory cytokines secreted by Kupffer cells, thus enhancing therapeutic effects against liver fibrosis.
The extracellular matrix (ECM) is a major driver of fibrotic diseases and forms dense fibrous barrier that impedes nanodrug delivery. Because hyperthermia causes destruction ECM components, we developed nanoparticle preparation to induce fibrosis-specific biological (designated as GPQ-EL-DNP) improve pro-apoptotic therapy against based on remodeling the microenvironment. GPQ-EL-DNP metalloproteinase (MMP)-9-responsive peptide, (GPQ)-modified hybrid containing fibroblast-derived exosomes...