A5057118417- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Blood properties and coagulation
- Iron Metabolism and Disorders
- Biosensors and Analytical Detection
- Blood groups and transfusion
- Bone and Joint Diseases
- SARS-CoV-2 detection and testing
- Hemoglobin structure and function
- Microfluidic and Capillary Electrophoresis Applications
- Digital Imaging for Blood Diseases
- Prenatal Screening and Diagnostics
- Global Health and Surgery
- Advanced biosensing and bioanalysis techniques
- Mosquito-borne diseases and control
- Pancreatic function and diabetes
- Malaria Research and Control
- Acute Myeloid Leukemia Research
- Genetics, Bioinformatics, and Biomedical Research
- Neonatal Health and Biochemistry
- Atomic and Subatomic Physics Research
- Electron Spin Resonance Studies
- Parvovirus B19 Infection Studies
- Blood disorders and treatments
- Advanced Biosensing Techniques and Applications
Case Western Reserve University
2021-2025
Makerere University
2018
A point-of-care diagnostic technology and approach is presented to perform both anemia detection hemoglobin variant identification in a single test using paper-based microchip electrophoresis.
In sickle cell disease (SCD), red blood cells (RBC) are poorly deformable, even under normoxia. With deoxygenation, deformability of RBCs is further reduced due to polymerization hemoglobin S (HbS). Rigid, deformable block microvasculature, causing ischemia, pain, and organ damage. The Microfluidic Impedance Red Cell Assay (MIRCA) can mechanically measure RBC deformability, providing occlusion index normoxia (NOI) or hypoxia (HOI) as readouts. We analyzed from 68 adult 34 pediatric SCD...
Hemoglobin (Hb) disorders affect nearly 7% of the world's population. Globally, around 400,000 babies are born annually with sickle cell disease (SCD), primarily in sub-Saharan Africa where morbidity and mortality rates high. Screening, early diagnosis, monitoring not widely accessible due to technical challenges cost. We hypothesized that multispectral imaging will allow sensitive hemoglobin variant identification existing affordable paper-based Hb electrophoresis. To test this hypothesis,...
We present a rapid hemoglobin-oxygen dissociation measurement approach to screen for and detect affinity abnormalities evaluate the function efficacy of hemoglobin modifying therapies within minutes.
Red blood cell (RBC) deformability is a valuable hemorheological biomarker that can be used to assess the clinical status and response therapy of individuals with sickle disease (SCD). RBC has been measured by ektacytometry for decades, which uses shear or osmolar stress. However, population based measurement does not detect small-fractions abnormal RBCs. A single cell-based, functional assay would complement provide additional information. Here, we tested relative merits OcclusionChip,...
<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective:</i> Effective management of diabetes largely benefits from early diagnosis followed by intensive long-term regulation blood glucose. The levels glycohemoglobin (HbA1 and HbA1c) have been used as standard biomarkers to assess glucose concentrations for management. Gold laboratory methods HbA1 HbA1c testing are often costly not widely available. Moreover, currently available...
We examined how surgical implants were accessed by orthopaedic trauma patients in selected public and private hospitals Kampala, Uganda. The study employed a series of interviews with professionals highly familiar this circumstance: surgeons from Mulago National Referral Hospital (MNRH), staff the MNRH Ministry Health (MOH) procurement departments. also interviewed who had received MNRH. Surgeons forthcoming describing made available to their offered several opinions on implant quality,...
Diabetes is responsible for 4.6 million deaths worldwide each year, and the prevalence of diabetes expected to rise 552 by 2030. not only a leading cause morbidity mortality, but its complications also impose large financial burden on patients their families. outcomes can be improved early detection monitoring. However, accurate diagnosis monitoring remain challenge, particularly in low- middle-income nations. Here, we present new microchip electrophoresis approach point-of-care (POC)...
A microfluidic assay integrated with capillary network-inspired microcapillary arrays and endothelial-associated protein functionalization enables concurrent assessment of red blood cell adhesion occlusion.