About
Contact & Profiles
A5107983077
Research Areas
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
Hebrew University of Jerusalem
2016
The poliovirus receptor (PVR) is a ubiquitously expressed glycoprotein involved in cellular adhesion and immune response. It engages the activating DNAX accessory molecule (DNAM)-1, inhibitory TIGIT, CD96 with both functions. Human cytomegalovirus (HCMV) down-regulates PVR expression, but significance of this viral function vivo remains unknown. Here, we demonstrate that mouse CMV (MCMV) also surface PVR. m20.1 protein MCMV retains endoplasmic reticulum promotes its degradation. A mutant...
10.1084/jem.20151899
article
EN
The Journal of Experimental Medicine
2016-08-08
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