A5091636635- Pharmacology and Obesity Treatment
- Complementary and Alternative Medicine Studies
- Lysosomal Storage Disorders Research
- Poisoning and overdose treatments
- Hormonal and reproductive studies
- Trypanosoma species research and implications
- Muscle metabolism and nutrition
- Forensic Toxicology and Drug Analysis
- Herbal Medicine Research Studies
- Ginkgo biloba and Cashew Applications
- Pharmaceutical studies and practices
- Glycogen Storage Diseases and Myoclonus
- Biosimilars and Bioanalytical Methods
- Parasitic Diseases Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Psychedelics and Drug Studies
- Neurotransmitter Receptor Influence on Behavior
- Pharmacogenetics and Drug Metabolism
- Coffee research and impacts
- Medicinal Plant Extracts Effects
- Bone health and osteoporosis research
- Biochemical effects in animals
- Metabolism and Genetic Disorders
- Psychoanalysis and Psychopathology Research
- Pharmacological Effects and Assays
Ultragenyx Pharmaceutical (United States)
2016-2019
BioMarin (United States)
2014-2017
Ibero American University
2015
Amgen (United States)
2008-2013
University of California, San Francisco
2000-2009
San Francisco General Hospital
2002-2008
Washington Poison Center
2000-2003
University of California System
2002
Weatherford College
2001
Dietary supplements that contain ephedra alkaloids (sometimes called ma huang) are widely promoted and used in the United States as a means of losing weight increasing energy. In light recently reported adverse events related to use these products, Food Drug Administration (FDA) has proposed limits on dose duration such supplements. The FDA requested an independent review reports contained assess causation estimate level risk poses consumers.
Polymorphism in the genes for cytochrome (CYP)2C9 and vitamin K epoxide reductase complex subunit 1 (VKORC1) affect pharmacokinetics pharmacodynamics of warfarin. We developed validated a warfarin-dosing algorithm multi-ethnic population that predicts best dose stable anticoagulation, compared its performance against other regression equations.We determined allele haplotype frequencies CYP2C9 VKORC1 on 167 Caucasian, African-American, Asian Hispanic patients On subset where complete data...
Cotinine, a metabolite of nicotine, has been used to study tobacco smoke exposure in population studies, but the authors are unaware its use screen hospitalized patients. The measured serum cotinine levels 948 patients admitted an urban public hospital San Francisco, California, between September 2005 and July 2006. On basis levels, they classified as active smokers (cotinine > or = 14 ng/mL), recent significantly exposed secondhand (SHS) (0.5-13.9 lightly SHS (0.05-0.49 unexposed (<0.05...
To report and discuss the multi-domain impact of elosulfase alfa, with focus on tertiary composite endpoints, in 24-week, randomized, double-blind, placebo-controlled phase 3 trial patients Morquio A syndrome (mucopolysaccharidosis IVA).Patients aged ≥5 years were randomized 1:1:1 to alfa 2.0mg/kg/week (qw; N=58), 2.0mg/kg/every other week (qow; N=59), or placebo (N=59) for 24 weeks. Primary secondary efficacy measures 6-minute walk test (6MWT; primary), 3-minute stair climb (3-MSCT) urinary...
Objective Serious cardiovascular toxicity has been reported in people taking dietary supplements that contain ma huang (Ephedra) and guarana (caffeine). We assessed the pharmacokinetics pharmacodynamics of a supplement contains these herbal stimulants. Methods Eight healthy adults received single oral dose thermogenic labeled to 20 mg ephedrine alkaloids 200 caffeine after an overnight fast. Serial plasma urine samples were analyzed by use liquid chromatography‐tandem mass spectrometry for...
Background: Gamma-hydroxybutyrate (GHB) is a common drug of abuse that can produce serious toxicity, particularly when used with other sedatives. We examined the individual and combined effects GHB ethanol in human volunteers. Methods: Sixteen healthy adults (7 men) were given 50 mg/kg (Xyrem), 0.6 g/kg 2 doses, alone double-blind, placebo-controlled, crossover study. Plasma concentrations, heart rate (HR), blood pressure (BP), oxygen saturation (O2sat) serially monitored for 24 hours....
Drug development for ultra-rare diseases is challenging because small sample sizes and heterogeneous study populations hamper the ability of randomized, placebo-controlled trials with a single primary endpoint to demonstrate valid treatment effects.To overcome these challenges, novel Blind Start design was utilized in vestronidase alfa mucopolysaccharidosis VII (Sly syndrome), an lysosomal disease, that demonstrates strengths this approach drug-development setting. Twelve subjects were...
Performance-enhancing dietary supplements have not been clinically tested for safety or efficacy. In clinical trials performed under resting conditions, performance-enhancing raise blood pressure and affect glucose homeostasis. The effect of exercise on the pharmacokinetics pharmacodynamics stimulant herbals is unknown.Supplement-induced effects levels are ameliorated by exercise. Exercise does kinetics ingredients, caffeine synephrine. supplement use modestly improves tolerance. AIMS...
1,4-Butanediol (BD) is converted to gamma-hydroxybutyrate (GHB) after ingestion, and associated with cases of dependence, coma, death. The pharmacology BD oral ingestion has not been described in humans. Eight healthy volunteers (five men) were administered 25 mg/kg a single dose an overnight fast double-blinded, placebo-controlled, crossover study. Vital signs monitored, serial blood samples collected over 24 h for gas chromatography-mass spectrometry analysis GHB levels. Subjective mood...
Confirmation of opioids in urine samples clinical patients requires liberation from their glucuronide conjugates. Both acid hydrolysis and enzyme using beta-glucuronidase various sources have been reported, with the latter approach prevailing most toxicology laboratories. The goal this study was to compare efficiency versus different methods recovering morphine common semisynthetic standards 78 patient that were screened positive for as a class. Specimens analyzed validated gas...
Dietary supplements that contain Ma Huang (ephedra alkaloids) and guarana (caffeine) are widely marketed used in the U.S. for weight loss athletic performance enhancement, despite a lack of adequate research on pharmacology these botanical stimulants. We developed applied novel liquid chromatography-tandem mass spectrometry (LC-MS-MS) method to quantitate various ephedra alkaloids found dietary Ephedra species. The quantities ephedrine, pseudoephedrine, norephedrine, norpseudoephedrine,...
Gamma-hydroxybutyric acid (GHB) is used as an illicit drug and implicated in drug-facilitated sexual assault, but it also has some therapeutic uses. Detection of GHB urine important for forensic testing could be clinical benefit overdose management. Urine concentration-time profiles have not been well-characterized or correlated with doses therapeutically. levels were measured by gas chromatography-mass spectrometry collected over 24 h from 16 adults administered single 50 mg/kg (Xyrem®)...
Many conventional drugs (for example, isoniazid and valproic acid) are well recognized as possible hepatotoxins.1 Several herbal medicines have also been reported to hepatotoxic effects. However, may not always be considered the etiologic agent in cases of unexplained liver injury. Current mechanisms track adverse effects inadequate.2 Consumers generally consider safe view them natural alternatives traditional medications. A recent study showed that only 40% people who use informed their...
ABSTRACT Purpose To describe the rationale and methods for a prospective, open‐cohort study assessing long‐term safety of Prolia ® treatment postmenopausal osteoporosis (PMO) in postmarketing settings. Methods Data will be derived from United States Medicare, Healthcare, Nordic (Denmark, Sweden, Norway) national registries. Observation begin on date first regulatory approval (May 26, 2010) continue 10 years. Women with PMO identified by age, diagnosis, osteoporotic fracture, or treatment....
Mucopolysaccharidosis type VII (MPS VII, Sly Syndrome) is a progressive, debilitating, ultra-rare lysosomal storage disorder caused by the deficiency of β-glucuronidase (GUS), an enzyme required for breakdown glycosaminoglycans (GAGs). Vestronidase alfa, recombinant human GUS, replacement therapy approved in US and EU treatment MPS VII.The pharmacokinetics (PK) pharmacodynamics (PD) vestronidase alfa were evaluated 23 adult pediatric subjects with enrolled phase I-III clinical trials to...
Dietary supplements containing botanical forms of caffeine and ephedra alkaloids have been widely promoted used in the U.S. for weight loss athletic enhancement despite a lack adequate research on pharmacology these stimulants. In order to analyze dietary perform human pharmacokinetic studies, an analytical approach with good precision accuracy was needed sufficient sensitivity detect very low levels alkaloids. A liquid chromatography-atmospheric pressure chemical ionization (APCI) tandem...