A5101541125- Tuberous Sclerosis Complex Research
- Scientific Computing and Data Management
- Research Data Management Practices
- Renal and related cancers
- Histiocytic Disorders and Treatments
- Extracellular vesicles in disease
- Prostate Cancer Treatment and Research
- Immunotherapy and Immune Responses
- Data Quality and Management
- Artificial Intelligence in Healthcare
- Data Analysis with R
- Genetic and Kidney Cyst Diseases
- Rabbits: Nutrition, Reproduction, Health
- Cardiovascular Disease and Adiposity
- Chemokine receptors and signaling
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Kruppel-like factors research
- Telomeres, Telomerase, and Senescence
- Renal cell carcinoma treatment
- Cancer-related Molecular Pathways
- Caching and Content Delivery
- Cancer Immunotherapy and Biomarkers
- Pulmonary Hypertension Research and Treatments
- Data-Driven Disease Surveillance
Texas Tech University
2015-2025
Texas Tech University Health Sciences Center
2015-2025
Virginia Commonwealth University
2025
Mountain View College
2024
Virginia Commonwealth University Medical Center
2024
Hunter Holmes McGuire VA Medical Center
2024
National Cancer Institute
2020-2023
Division of Cancer Epidemiology and Genetics
2020-2023
Cancer Institute (WIA)
2023
Children's Hospital of Richmond at VCU
2020
Androgen deprivation therapy (ADT) is the cornerstone treatment strategy for men diagnosed with high-risk prostate cancer (PC) but may increase risk major adverse cardiovascular events (MACE). We examined whether treated ADT and radiation (ADT + RT) developed MACE at a higher rate than receiving RT alone. Secondly, we sought to determine if Black White men. This retrospective cohort study time diagnosis of among Veterans PC. used 1:1 propensity score matching process type vs. alone), race...
Abstract Data sharing is essential for reproducibility of epidemiologic research, replication findings, pooled analyses in consortia efforts, and maximizing study value to address multiple research questions. However, barriers related confidentiality, costs, incentives often limit the extent speed data sharing. Epidemiological practices that follow Findable, Accessible, Interoperable, Reusable (FAIR) principles can these by making resources findable with necessary metadata, accessible...
Abstract In the metastasis-targeted organs, angiogenesis is essential for progression of dormant micrometastases to rapidly growing and clinically overt lesions. However, we observed changes suggesting angiogenic switching in mouse lungs prior arrival tumor cells (i.e., premetastatic niche) models breast carcinoma. This appears be caused by myeloid-derived suppressor recruited through complement C5a receptor 1 signaling. These myeloid are known secrete several proangiogenic factors tumors,...
<title>Abstract</title> Pulmonary lymphangioleiomyomatosis (LAM) is metastatic sarcoma but mechanisms of LAM metastasis are unknown. Extracellular vesicles (EV) regulate cancer their roles in have not yet been thoroughly investigated. Here, we report the discovery distinct LAM-EV subtypes derived from primary tumor or metastasizing cells that promote through ITGα6/β1-c-Src-FAK signaling, triggered by shuttling ATP synthesis to cell pseudopodia activation integrin adhesion complex,...
Ovotransferrin (OVT) is one of the major proteins egg white and known to bind transport irons in animals. OVT exerts bacteriostatic bactericidal activities due its iron-binding capacity. effectively controls growth various pathogenic microorganisms, including Pseudomonas, E. coli, Staphylococcus, Proteus, Klebsiella species, as well inhibiting replication viruses. also has antioxidant, anti-inflammatory, anti-hypertensive, anticancer, immuno-stimulating properties. For instances, quenches...
Abstract Patients with cirrhosis have intestinal barrier dysfunction but the role of individual cell types in human small intestine is unclear. We performed single-nuclear RNA sequencing (snRNAseq) pinch biopsies terminal ileum four age-matched men [56 years, healthy control, compensated, early (ascites and lactulose use) advanced decompensated rifaximin use)]. Cell type proportions, differential gene expressions, cell-type specific pathway analysis using IPA, cellular crosstalk dynamics...
Abstract Differentiation abnormalities are a hallmark of tuberous sclerosis complex (TSC) manifestations; however, the genesis these remains unclear. Here we report on mechanisms controlling multi-lineage, early neuronal progenitor and neural stem-like cell characteristics lymphangioleiomyomatosis (LAM) angiomyolipoma cells. These include activation previously unreported Rheb-Notch-Rheb regulatory loop, in which cyclic binding Notch1 to Notch-responsive elements (NREs) Rheb promoter is key...
There is increasing interest in sharing the experience of products and services on web platform, social media has opened a way for product service providers to understand their consumers needs expectations. This paper explores reviews by cloud that reflect experiences with services. The around 6,000 users were analysed using sentiment analysis identify attitude each review, determine whether opinion expressed was positive, negative, or neutral. used two data mining tools, KNIME RapidMiner,...
Abstract Motivation Mortality Tracker is an in-browser application for data wrangling, analysis, dissemination and visualization of public time series mortality in the United States. It was developed response to requests by epidemiologists portable real assessment effect COVID-19 on other causes death all-cause mortality. This performed comparing 2020 values with observations from same week previous 5 years, enabling extraction temporal snapshots that facilitate modeling interdependence...
We discovered that 90.3% of patients with angiomyolipomas, lymphangioleiomyomatosis (LAM), and tuberous sclerosis complex (TSC) carry the arginine variant codon 72 (R72) TP53 R72 increases risk for angiomyolipoma. transactivates NOTCH1 NODAL better than proline (P72); therefore, expression is increased in angiomyolipoma cells R72. The loss Tp53 Tsc1 within nestin-expressing mice resulted development renal cell carcinomas (RCC) high Notch1 Nodal expression, suggesting similar downstream...
Reproducibility and replicability of research findings are central to the scientific integrity epidemiology. In addition, many questions require combiningdata from multiple sources achieve adequate statistical power. However, barriers related confidentiality, costs, incentives often limit extent speed sharing resources, both data code. Epidemiological practices that follow FAIR principles can address these by making resources (F)indable with necessary metadata , (A)ccessible authorized users...
Pulmonary lymphangioleiomyomatosis (LAM) is metastatic sarcoma but mechanisms regulating LAM metastasis are unknown. Extracellular vesicle (EV) regulate cancer their roles in have not yet been investigated. Here, we report that EV biogenesis increased and cargo enriched with lung tropic integrins, metalloproteinases, stem cell markers. LAM-EV increase migration invasion via the ITGα6/β1-c-Src-FAK-AKT axis. Metastable (hybrid) phenotypes of metastasizing cells, pivotal for metastasis,...
Abstract The role of the most common TP53 single-nucleotide polymorphism (SNP) at codon 72, which encodes for proline (P72) or arginine (R72), in regulation immune system has not yet been thoroughly explored. We found that this SNP contributes to aggravated inflammatory response COVID-19 patients resulting from biased macrophage activation. R72-P53 inhibits mitochondrial manganese superoxide dismutase, leading impaired reactive oxygen species scavenging, oxidation phosphatase and tensin...
CD59, a GPI-anchored membrane protein, protects cancer cells from complement-dependent cytotoxicity (CDC) by inhibiting the formation of attack complex (MAC). It has been demonstrated to be overexpressed in most solid tumors, where it facilitates tumor cell escape complement surveillance. The role CD59 growth and interactions between immune that modulate evasion not well explored.
Abstract Background Online questionnaires are commonly used to collect information from participants in epidemiological studies. This requires building using machine-readable formats that can be delivered study web-based technologies such as progressive web applications. However, the paucity of open-source markup standards with support for complex logic make collaborative development questionnaire modules difficult. often prevents interoperability and reusability across Results We developed...
<p>S1. Expression of hamartin and p53 in mice. S2. CRISPR-Cas9 mediated editing TP53 codon 72 angiomyolipoma cells the impact R72 on Notch/Nodal axis. S3. Overexpression Nodal LAM. S4. TSC-associated renal tumors. S5. increases migration cells. Supplementary Table S1. The frequency germline polymorphism TSC LAM patients. sporadic RCC. number experimental mice used study.</p>
<p>S1. Expression of hamartin and p53 in mice. S2. CRISPR-Cas9 mediated editing TP53 codon 72 angiomyolipoma cells the impact R72 on Notch/Nodal axis. S3. Overexpression Nodal LAM. S4. TSC-associated renal tumors. S5. increases migration cells. Supplementary Table S1. The frequency germline polymorphism TSC LAM patients. sporadic RCC. number experimental mice used study.</p>
<div>Abstract<p>We discovered that 90.3% of patients with angiomyolipomas, lymphangioleiomyomatosis (LAM), and tuberous sclerosis complex (TSC) carry the arginine variant codon 72 (R72) <i>TP53</i> R72 increases risk for angiomyolipoma. transactivates <i>NOTCH1</i> <i>NODAL</i> better than proline (P72); therefore, expression is increased in angiomyolipoma cells R72. The loss <i>Tp53</i> <i>Tsc1</i> within...
Online questionnaires are commonly used to collect information from participants in epidemiological studies. This requires building using machine-readable formats that can be delivered study web-based technologies such as progressive web applications. However, the paucity of open-source markup standards with support for complex logic make collaborative development questionnaire modules difficult. often prevents interoperability and reusability across studies.We developed an language...