A5095376776- Signaling Pathways in Disease
- Ubiquitin and proteasome pathways
- Hereditary Neurological Disorders
Instituto de Investigación Sanitaria de Santiago
2024
Center for Research in Molecular Medicine and Chronic Diseases
2024
Universidade de Santiago de Compostela
2024
Myelination is essential for neuronal function and health. In peripheral nerves, >100 causative mutations have been identified that cause Charcot-Marie-Tooth disease, a disorder can affect myelin sheaths. Among these, number of are related to targets the posttranslational modification neddylation, although how these lead defects unclear. Here, we demonstrate inhibiting neddylation leads notable absence axonal loss both in developing regenerating mouse nerves. Our data indicate exerts...