A5063294416- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Genomic variations and chromosomal abnormalities
- Galectins and Cancer Biology
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Fetal and Pediatric Neurological Disorders
- Prenatal Screening and Diagnostics
CHA University
2022-2023
Samsung Medical Center
2021-2022
Background The intestinal microenvironment directly determines the human T-cell receptor (TCR) repertoire. Despite its extreme diversity, TCR repertoire analysis may provide a better understanding of immune system in patients with inflammatory bowel disease. Methods To investigate repertoires mucosa, RNA sequencing was performed for inflamed and non-inflamed mucosa samples obtained from 13 Crohn’s disease (CD) healthy nine non-IBD controls. Results gene expression frequency showed clear...
High-grade serous ovarian carcinoma (HGSOC) is a fatal gynecological malignancy. Somatic recombination occurring during T-cell receptor (TCR) development results in TCR diversity, and the repertoire, thus produced, associated with immune response. This study analyzed difference repertoire their prognostic significance 51 patients HGSOC. The patient’s clinical characteristics, gene expression pattern, clonotypes, degree of tumor-infiltrating leukocytes (TILs) were analyzed, divided into...
The risk of chromosomal abnormalities in the child increases with increasing maternal age. Although non-invasive prenatal testing (NIPT) is a safe and effective screening method, accuracy test results needs to be improved owing various conditions. We attempted achieve more accurate robust prediction by combining multiple methods. Here, three different methods, namely standard Z-score, normalized chromosome value, within-sample reference bin, were used for 1698 109 samples whole-genome...
Prostate cancer has long been considered a disease with heterogeneous phenotype. The in-tratumor heterogeneity (ITH) may affect diverse phenotypes such as treatment response, drug resistance, and overall clinical outcomes. Despite technical advances over the past decade, we have an incomplete understanding of extent effects ITH in prostate progression. We present here comprehensive review various studies dealing pros-tate cancer. discuss advanced next-generation sequencing analyses including...