A5019230260- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Glycosylation and Glycoproteins Research
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Effects of Radiation Exposure
- Monoclonal and Polyclonal Antibodies Research
- Erythrocyte Function and Pathophysiology
- Immunodeficiency and Autoimmune Disorders
- Hematological disorders and diagnostics
- Alkaline Phosphatase Research Studies
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Molecular Biology Techniques and Applications
- Hematopoietic Stem Cell Transplantation
- Lung Cancer Treatments and Mutations
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Radiation Dose and Imaging
- Occupational and environmental lung diseases
- Multiple Myeloma Research and Treatments
- Bone and Joint Diseases
- Cell Adhesion Molecules Research
- thermodynamics and calorimetric analyses
- Pleural and Pulmonary Diseases
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology
2012-2023
National Academy of Sciences of Ukraine
2005-2023
University of Göttingen
1998
N.D. Zelinsky Institute of Organic Chemistry
1995
The psychological effects of technological disasters have rarely been studied in children. This study assessed the aftermath 1986 Chornobyl disaster children evacuated to Kyiv from contaminated zone surrounding nuclear power facility.In 1997, we evaluated three hundred 10- 12-year-old who were utero or infants at time and had resided near (evacuees) 300 sex-matched homeroom classmates never lived a radiation-contaminated area. Response rates 92% 85% (classmates). Data obtained children,...
Cell surface expression of CD150 and CD180 receptors in chronic lymphocytic leukemia (CLL) associates with mutational IGHV status favourable prognosis. Here we show a direct correlation between cell colocalization these on CLL B cells. In the absence both were expressed cytoplasm. The receptor was colocalized markers endoplasmic reticulum, Golgi apparatus early endosomes. contrast, detected preferentially Analysis isoforms differential revealed that regardless mCD150 isoform two ITSM...
Exposure to ionizing radiation is associated with increasing risk of various types hematological malignancies. The results major studies on association leukemias and exposure large populations in Japan Ukraine are analyzed. patterns different leukemia 295 Chernobyl clean-up workers diagnosed according the criteria up-to-date World Health Organization classification within 10-25 years following catastrophe summarized. In fact, a broad spectrum radiation-related malignancies has been revealed...
Acute myeloid leukemia (AML) is a highly heterogeneous disease accompanied by the arrest of cell lineage differenti-ation due to accumulation genetic abnormalities and clonal proliferation blasts. Finding differentially expressed molecules studying their function within AML subgroups may help improve diagnosis prognosis with aim developing selected therapies for subsets. The this study was reveal profile CD150 surface expression on bone marrow (BM) cells patients.The performed samples BM...
According to the conclusion of International Programme on Health Effects Chernobyl Accident (IPHECA) Haematology Pilot Project (1991-1995), there was no increase in incidence malignant disease hematopoietic and lymphoid tissues after accident. Nevertheless, since studies A-bomb survivors indicate that peak morbidity may occur more than 10 years radiation exposure, long-term hemoblastoses myelodysplastic syndromes are needed today. Study these leukemias lymphomas potentially induced by...
High oligosaccharide specificity for binding carbohydrate probes (biotinylated polyacrylamide with carbohydrates attached) human hemopoietic and lymphoid cells is shown. Of 15 studied those bearing blood group trisaccharides, A B, bound most intensely. In addition, transformed (leukemic lymphoid) interacted more strongly than normal ones.
Background : Even in 25 years after Chernobyl catastrophe, the interpretation of findings on leukemia risk among clean-up workers is still a point much controversy. Precise diagnosis main types hematopoietic malignancies according to FAB classification and new WHO comparison these data with that general population will be helpful estimating relative contribution radiation factor overall incidence such pathologies. Methods The 295 consecutive cases malignant tumors lymphoid tissues diagnosed...
During 1993-1997, 247 cases of childhood acute leukemia (AL) were analyzed among inhabitants the city Kiev and region, excluding most contaminated areas belonging to strict control zone. The criteria an FAB classification supplemented by immunophenotyping data applied. AL pattern was shown be quite typical except for several peculiar features characteristic this regional group patients, especially absence age peaks in children with myelogenous leukemias (AML), increased frequency T1 variant...
Summary. Placental-like alkaline phosphatase (PLAP) is expressed by many tumors and can be detected in sera of patients with various cancers. Its aberrant expression has been considered to potentially useful as tumor marker. However, the biological background role this (AP) cancer still unclear. The forms AP cells chronic myeloid leukemia (CML) not yet studied. Aim: To analyze patterns originated from CML blast crisis modify their vitamin E. Materials Methods: RNA extracted leukemic was...
Nuclear factor kappa B (NF-κB) is an important transcription in cancer and NF-κB activation has been seen angiogenesis, tumor progression, metastasis. Relationships between specific gene networks, leukemogenesis, radiation exposure are still unknown. Our aim was to study the expression levels of NF-κB1, NF-κB2, Rel genes hematological malignancies post-Chernobyl period.We analyzed 49 B-cell chronic lymphocytic leukemia, 8 non-Hodgkin's lymphoma, 3 acute myeloid 2 hairy cell myelodysplastic...