A5018361910- Porphyrin and Phthalocyanine Chemistry
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Synthetic Organic Chemistry Methods
- Photochromic and Fluorescence Chemistry
- Nanoparticle-Based Drug Delivery
- Lanthanide and Transition Metal Complexes
- Dendrimers and Hyperbranched Polymers
- Analytical Chemistry and Sensors
- Molecular Sensors and Ion Detection
- Catalytic Cross-Coupling Reactions
- Advanced Polymer Synthesis and Characterization
- Synthesis and Biological Evaluation
- Cancer Research and Treatments
- Chemical Synthesis and Analysis
- Oxidative Organic Chemistry Reactions
- Silicone and Siloxane Chemistry
- Liquid Crystal Research Advancements
- Organic Light-Emitting Diodes Research
- Photochemistry and Electron Transfer Studies
- Aerogels and thermal insulation
G.A. Razuvaev Institute of Organometallic Chemistry
2014-2024
Theranostics (New Zealand)
2020
Search (Poland)
2020
N. I. Lobachevsky State University of Nizhny Novgorod
2016-2018
Yaroslav-the-Wise Novgorod State University
2018
Russian Academy of Sciences
2012
The immunogenicity of dying cancer cells determines the efficacy anti-cancer therapy. Photodynamic therapy (PDT) can induce immunogenic cell death (ICD), which is characterized by emission damage-associated molecular patterns (DAMPs) from cells. This trigger effective anti-tumor immunity. Only a few photosensitizers are known to ICD and, therefore, there need for development new that ICD. purpose this work was analyze whether developed in-house porphyrazines (pz I and pz III) in vitro vivo...
An approach to the synthesis of new regular graft-copolymers polyimide (PI)-graft-polymethacrylic acid is elaborated, including (1) multicenter PI macroinitiators, (2) controlled ATRP tert-butylmethacrylate on prepared and (3) protonolysis tert-butyl ester groups side chains resulting PI-graft-poly(tert-butylmethacrylate). Experimental conditions for attaining complete conversions first third stages process are determined by means 1H NMR FTIR-spectroscopy. Polymer products second process, as...
Porphyrazines have recently emerged as a useful class of tetrapyrroles suitable for photodynamic therapy cancer (PDT) with excellent uptake and retention properties in vivo. Here we demonstrate that the photophysical cyano-aryl porphyrazine pz1 are strongly viscosity dependent, i.e. fluorescence lifetime quantum yield increase function solution viscosity. We calibrated red-emitting fluorescent 'molecular rotor' large range viscosities from 80 to ca. 5500 cP, solutions various solvent...
Abstract Photodynamic therapy (PDT) is a clinically approved procedure for targeting tumor cells. Though several different photosensitizers have been developed, there still much demand novel with improved properties. In this study we aim to characterize the accumulation, localization and dark cytotoxicity of developed in‐house derivatives porphyrazines ( pz I‐IV) in primary murine neuronal cells, as well identify concentrations at which effectively induces death glioma cells yet nontoxic...
Efficient drug delivery can be assigned to tasks that attract the most acute attention of researchers in field anticancer design. We have reported first case using amphiphilic polymer brushes as nanocontainers for photosensitizer cancer cells. Regular graft‐copolymers hydrophobic polyimides with hydrophilic polymethacrylic acid side chains were loaded photosensitive dye tetra(4‐fluorophenyl)tetracyanoporphyrazine (Pz) providing a sufficiently stable homogeneous fraction fluorescent Pz‐loaded...
Research in the past decade on immunogenic cell death (ICD) has shown that immunogenicity of dying tumor cells is crucial for effective anticancer therapy. ICD induction leads to emission specific damage-associated molecular patterns (DAMPs), which act as danger signals and adjuvants activate anti-tumor immune responses, leading elimination formation long-term immunological memory. can be triggered by many treatment modalities, including photodynamic therapy (PDT). However, due variety...
The current efforts in photodynamic therapy (PDT) of brain cancer are focused on the development novel photosensitizers with improved properties, targeted specific localization, and sensitivity to irradiation dose, ensuring effectiveness PDT fewer side effects for normal nerve tissue. Here, we characterize four tetracyanotetra(aryl)porphyrazine group (pz I-IV) functional activity neuron-glial networks primary hippocampal cultures their application conditions under PDT. data revealed that pz...
Despite the significant relevance of photodynamic therapy (PDT) as an efficient strategy for primary and adjuvant anticancer treatment, several challenges compromise its efficiency. In order to develop “ideal photosensitizer” requirements applied photosensitizers PDT, there is still a need new agents with improved photophysical photobiological properties. this study, we performed detailed characterization two tetracyanotetra(aryl)porphyrazine dyes 4-biphenyl (pz II) 4-diethylaminophenyl IV)...
Today we see an increasing demand for new fluorescent materials exhibiting various sensory abilities due to their broad applicability ranging from the construction of flexible devices bioimaging. In this paper, report on pigments AntTCNE, PyrTCNE, and PerTCNE which consist 3-5 fused aromatic rings substituted with tricyanoethylene fragments forming D-π-A diad. Our studies reveal that all three compounds exhibit pronounced rigidochromic properties, i.e., strong sensitivity fluorescence...
The unique cyanoporphyrazine pigment with four bulky phenanthrenyl peripheral substituents has been prepared.It demonstrates the noticeable shift of Q-band to longer wavelengths due phenanthryl aromatic system extension.The compound showed very strong predominance photoinduced cytotoxicity over in dark.The presented results indicate enhancement photodynamic properties porphyrazine containing polycyclic aryl framing.It is confirmed that chemical design groups an efficient toolkit for a fine...
The aim of the study was to compare relevance ovarian adenocarcinoma spheroids with that a monolayer culture for assessing photodynamic effect tetrakis(4-benzyloxyphenyl)tetracyanoporphyrazine photosensitizer.The work performed on SKOV-3 human ovary cells grown in vitro and form tumor obtained using plates ultra-low attachment. We determined photoinduced toxicity porphyrazine MTT assay; tested by dynamics their growth. Cellular uptake analyzed confocal microscopy.Porphyrazine has pronounced...
Photodynamic therapy (PDT) is a rapidly developing modality of primary and adjuvant anticancer treatment. The main trends today are the search for new effective photodynamic agents creation targeted delivery systems with function controlling release agent in tumor. Recently, group cyanoarylporphyrazine dyes was reported, which combine properties photosensitizers sensors local microenvironment. Such unique characteristics allow photosensitizer from transport carrier to be assessed real time...
New water-soluble polynorbornenes P1–P4 containing oligoether, amino acid groups and luminophoric complexes of iridium(III) were synthesized by ring-opening metathesis polymerization. The polymeric products in organic solvents water demonstrate intense photoluminescence the red spectral region. polymers P1 P3 with 1-phenylisoquinoline cyclometalating ligands iridium fragments reveal 4–6 fold higher emission quantum yields solutions than those P2 P4 that contain 1-(thien-2-yl)isoquinoline...