A5077287195- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Neurological disorders and treatments
- Phytochemicals and Antioxidant Activities
- Inflammasome and immune disorders
- Chemotherapy-induced cardiotoxicity and mitigation
- Free Radicals and Antioxidants
- Cardiomyopathy and Myosin Studies
- Antioxidant Activity and Oxidative Stress
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Ischemia and Reperfusion
- Cardiac Structural Anomalies and Repair
- Pancreatic function and diabetes
- Esophageal Cancer Research and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Cardiovascular Function and Risk Factors
- Cancer Risks and Factors
- Cardiac Fibrosis and Remodeling
- Helicobacter pylori-related gastroenterology studies
- Hepatitis B Virus Studies
- Cancer Treatment and Pharmacology
- Parkinson's Disease Mechanisms and Treatments
- Gout, Hyperuricemia, Uric Acid
Wenzhou Medical University
2015-2025
First Affiliated Hospital of Wenzhou Medical University
2015-2025
The University of Texas Southwestern Medical Center
2022-2025
Southwestern Medical Center
2022-2025
Sichuan University
2008-2023
Guang Fu Hospital
2023
University of Arkansas for Medical Sciences
2022
Yonsei University
2022
Soongsil University
2022
University of South China
2022
Background: Left bundle branch pacing (LBBP) is a novel method and has been observed to have low stable thresholds in prior small short-term studies. The objective of this study was evaluate the feasibility safety LBBP large consecutive diverse group patients with long-term follow-up. Methods: This prospectively enrolled 632 pacemaker attempted from April 2017 July 2019. Pacing parameters, complications, ECG, echocardiographic measurements were assessed at implant during follow-up 1, 6, 12,...
Objectives His bundle pacing (HBP) can potentially correct left branch block (LBBB). We aimed to assess the efficacy of HBP LBBB and long-term clinical outcomes with in patients heart failure (HF). Methods This is an observational study HF typical who were indicated for therapy consecutively enrolled from one centre. Permanent leads implanted if correction threshold was <3.5V/0.5 ms or 3.0 V/1.0 ms. Pacing parameters, ventricular ejection fraction (LVEF), end-systolic volume (LVESV) New...
Background Clinical benefits from His bundle pacing ( HBP ) in heart failure patients with preserved and reduced left ventricular ejection fraction are still inconclusive. This study evaluated clinical outcomes of permanent atrial fibrillation narrow QRS who underwent atrioventricular node ablation for symptoms despite rate control by medication. Methods Results The enrolled 52 consecutive attempted symptomatic fibrillation. Echocardiographic end‐diastolic dimension, New York Heart...
Cold-pressed marionberry, boysenberry, red raspberry, and blueberry seed oils were evaluated for their fatty acid composition, carotenoid content, tocopherol profile, total phenolic content (TPC), oxidative stability index (OSI), peroxide value, antioxidant properties. All tested contained significant levels of alpha-linolenic ranging from 19.6 to 32.4 g per 100 oil, along with a low ratio n-6/n-3 acids (1.64-3.99). The ranged 12.5 30.0 micromoles kg oil. Zeaxanthin was the major compound in...
Bran samples of seven wheat varieties from four different countries were examined and compared for their phytochemical compositions antioxidant activities. Phenolic acid composition, tocopherol content, carotenoid profile, total phenolic content the composition bran, whereas measured activities free radical scavenging properties against 2,2-diphenyl-1-picrylhydrazyl radical, cation 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt, peroxide anion O2•-, oxygen chelating...
Seed flours from black raspberry, red blueberry, cranberry, pinot noir grape, and chardonnay grape were examined for their total fat content, fatty acid composition, phenolic content (TPC), anthocyanin (TAC), radical scavenging capacities against the peroxyl (ORAC) stable DPPH radicals, chelating capacity Fe2+, antiproliferative activities using HT-29 colon cancer cell line. Significant levels of detected in fruit seed profiles may differ those respective oils. Cranberry flour had highest...
Abstract Introduction Left bundle branch pacing (LBBP) has recently been reported to maintain left ventricular electrical synchrony with a low and stable threshold. However, the electrocardiogram (ECG) definitions of LBBP have not well established. We report four cases show characteristics ECG intracardiac electrogram (EGM) in LBBP. Methods Results Four patients, two an atrioventricular block (AVB) (LBBB), were included study. was performed ECGs EGMs collected compared at different outputs....
Background Persistent atrial fibrillation may lead to a higher probability of inappropriate shocks in heart failure patients with an implantable cardioverter‐defibrillator ( ICD ). The aim this study was evaluate the impact His‐Purkinje conduction system pacing combined atrioventricular node ablation improving function and preventing shock therapy these patients. Methods Results A total 86 consecutive persistent who had indications for implantation were enrolled from January 2010 March 2018....
Myocardial dysfunction is a serious consequence of sepsis and contributes to high mortality. Currently, the molecular mechanism myocardial induced by remains unclear. In present study, we investigated role gasdermin D (GSDMD) in cardiac septic mice underlying mechanism. C57BL/6 wild-type (WT) age-matched Gsdmd-knockout (Gsdmd-/-) were intraperitoneally injected with lipopolysaccharide (LPS) (10 mg/kg) mimic sepsis. The results showed that GSDMD-NT, functional fragment GSDMD, was upregulated...
Abstract Cold‐pressed onion, parsley, cardamom, mullein, roasted pumpkin, and milk thistle seed oils were characterized for their fatty acid (FA) composition, tocopherol content, carotenoid profile, total phenolic content (TPC), oxidative stability index (OSI), color, physical properties, radical‐scavenging capacities against peroxyl (oxygen capacity) stable DPPH (diphenylpicrylhydrazyl) radicals. Parsley oil had the highest oleic 81 g/100 g FA, lowest saturated fat among tested oils....
This research evaluated the effects of postharvest treatment and heat stress on availability wheat antioxidants using Ankor Trego varieties. The grain, bran, 40-mesh bran samples both were kept at 25, 60, 100 °C for 9 days. Samples taken day 0, 1, 2, 3, 5, extracted with pure ethanol examined antioxidant properties including scavenging activity against peroxyl (ORAC), cation ABTS, 2,2-diphenyl-1-picryhydrazyl (DPPH·) radicals, as well total phenolic content (TPC) acid composition. Both...
Palivizumab is a US Food and Drug Administration-approved monoclonal antibody for the prevention of respiratory syncytial virus (RSV) lower disease in high-risk infants. Motavizumab, derived from palivizumab with enhanced antiviral activity, has recently been tested humans. Although escape mutants have generated laboratory, development resistant RSV patients receiving not reported previously.
High and unstable capture thresholds affect the success rate of permanent His-bundle pacing (HBP). We aimed to introduce modified techniques during different periods corresponding HBP implantation.Patients from a single centre who had intrinsic QRS < 120 ms attempts were included in study. The parameters described for three based on procedural modifications, i.e. Stage 1 using conventional procedure (August 2012 May 2013), 2 with addition dual-lead method (June 2013 October 2014), 3 further...
Abstract Aims His-bundle pacing (HBP) combined with atrioventricular node (AVN) ablation has been demonstrated to be effective in patients atrial fibrillation (AF) and heart failure (HF) during medium-term follow-up there are limited data on the risk analysis of adverse prognosis this population. In study, we aimed evaluate long-term performance HBP following AVN AF HF. Methods results From August 2012 December 2017, consecutive HF narrow QRS who underwent were enrolled. The clinical...
Left bundle branch pacing (LBBP) is emerging as a novel option for physiological ventricular pacing. The impact of current injury (COI) at left (LBB) has not been previously evaluated.Consecutive patients with QRS duration less than 120 milliseconds referred LBBP in whom LBB potentials were recorded included from August 2018 to March 2019. We COI during and assessed its on the parameters complications implantation short term follow-up.A total 115 an identifiable potential implant included....
Short QT syndrome (SQT) is a rare but arrhythmogenic disorder featured by shortened ventricular repolarization and propensity toward life-threatening arrhythmias sudden cardiac death.This study aimed to investigate the single-cell mechanism of SQT using patient-specific gene-corrected induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs).One patient carrying missense mutation T618I in potassium voltage-gated channel subfamily H member 2 ( KCNH2) was recruited as well healthy...