A5110688613- HIV/AIDS Research and Interventions
- Breastfeeding Practices and Influences
- Adolescent Sexual and Reproductive Health
- Child Nutrition and Water Access
- Global Maternal and Child Health
- Child Nutrition and Feeding Issues
- HIV Research and Treatment
- Child and Adolescent Health
- HIV-related health complications and treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Endometriosis Research and Treatment
- HIV, Drug Use, Sexual Risk
- Uterine Myomas and Treatments
- Nutrition, Genetics, and Disease
- COVID-19 Pandemic Impacts
- ICT in Developing Communities
- Public Procurement and Policy
- Adolescent and Pediatric Healthcare
- Dental Education, Practice, Research
- Pregnancy and Medication Impact
- Ethics in Clinical Research
- Lymphoma Diagnosis and Treatment
- International Development and Aid
- Immune Cell Function and Interaction
- Neonatal and fetal brain pathology
Vrije Universiteit Amsterdam
2025
Amsterdam University Medical Centers
2023-2025
University of Cape Town
2012-2024
The University of Western Australia
2021
Massachusetts General Hospital
2017
Dana-Farber Cancer Institute
1996
To assess neurodevelopment of breastfed HIV-exposed uninfected (HEU) and HIV-unexposed children in the context universal maternal antiretroviral therapy (ART).Prospective study with antenatal enrolment follow-up breastfeeding HEU mother-infant pairs through 12-18 months postpartum.Peri-urban community, Cape Town, South Africa.HEU (n = 215) 306) children.Cognitive, motor language development at median 13 (interquartile range 12-14) age: continuous dichotomous Bayley Scales Infant Toddler...
Introduction Early infant diagnosis (EID) and prompt linkage to care are critical minimise the high morbidity mortality associated with HIV infection. Attrition in "EID cascade" is common; however, point-of-care (POC) EID assays same-day result could facilitate of HIV-infected treatment. Despite a number POC development, few have been independently evaluated data on new technologies urgently needed inform policy. Methods We compared Alere q 1/2 Detect system laboratory test characteristics...
Objectives: Increased risk of morbidity and hospitalization has been observed in children who are HIV-exposed uninfected (HEU) compared with HIV-unexposed (HUU). Studies the era universal maternal antiretroviral treatment (ART) limited. Design: Prospective cohort. Methods: We investigated between 29 days 12 months life a South African cohort infants born February 2017 January 2019 (HEU = 455; HUU 458). All mothers known HIV during pregnancy received ART. reviewed hospital records classified...
Background Early infant HIV diagnosis (EID) coverage and uptake remains challenging. Point-of-care (POC) testing may improve access turn-around-times, but, while several POC technologies are in development there few data on their implementation the field. Methods We conducted an study of Alere q Detect system for EID at two public sector health facilities Cape Town. HIV-exposed neonates undergoing routine a large maternity hospital primary care clinic received both laboratory-based PCR per...
Despite the wealth of evidence about benefits breastfeeding, commercial milk formula (CMF) industry continues to grow and project future profits, fuelled by aggressive pervasive marketing practices that include targeting health care professionals. When professionals their associations accept funding from CMF industry, this creates a conflict interest (COI). The World Health Organization (WHO) United Nations Children’s Fund (UNICEF) have therefore issued clear unequivocal guidance including...
Although fentanyl and esketamine, administered intravenously (IV) or intranasally (IN), are standard of care for treatment acute traumatic pain in the prehospital setting Netherlands, comparative evidence regarding their efficacy safety is lacking. Therefore, this study aims to assess IN, esketamine IV IN as compared management setting. This a double-blind, monocenter, multi-arm, randomized non-inferiority trial Netherlands. Adult subjects receiving emergency from Emergency Medical Services...
Elevated HIV viral load (VL) in pregnancy has been linked to increased risk of mortality, immunologic abnormalities, infectious morbidity and restricted growth among HIV-exposed uninfected (HEU) children, but little is known about effects on child development.HIV-infected women initiating lifelong antiretroviral therapy (ART; tenofovir + emtricitabine efavirenz) antenatally were followed from first antenatal visit through delivery with their breastfed infants postpartum. Cognitive, motor...
Introduction: Polymerase chain reaction testing at birth (“birth-testing”) is suggested by new World Health Organization guidelines for rapid diagnosis of infants infected with HIV in utero. However, there are few data on the implementation this approach sub-Saharan Africa, and whether affects uptake subsequent routine early infant (EID) 6–10 weeks age unknown. Methods: We reviewed 575 consecutive undergoing targeted high-risk Cape Town, South matched those negative (n = 551) to HIV-exposed...
Abstract Breastfeeding education and support are critical health worker skills. Confusion surrounding infant feeding advice linked to the HIV epidemic has reduced confidence of workers breastfeeding. High antiretroviral therapy coverage breastfeeding women living with HIV, an Infant Feeding policy supportive breastfeeding, now provides opportunity improve practices. Challenges remain in restoring This qualitative study presents findings from focus group discussions mothers young infants,...
Despite clear evidence of the benefits exclusive and continued breastfeeding for children, women society, far too few children in South Africa (SA) are breastfed. One major impediments to improving this situation is aggressive marketing breastmilk substitutes (BMSs) infiltration BMS industry into contexts with exposure health professionals. In article we, as academics, practitioners child advocates, describe contraventions regulations that protect SA argue bold, proactive leadership...
Abstract Introduction To strengthen the early infant diagnosis ( EID ) programmes and timeously identify treat HIV ‐infected infants, birth ‐ PCR for some/all infants has been recommended in Western Cape, South Africa since 2014. Operational data on implementation of such low‐ middle‐income countries are limited. Methods Utilizing electronic records platform at primary care facilities, we developed an register which consolidated obstetric ‐related data, allowing us to track a cohort...
Abstract Introduction The virtual elimination of mother‐to‐child transmission HIV cannot be achieved without complete maternal testing. World Health Organization recommends that women in high prevalent settings repeat testing the third trimester, and at delivery or directly thereafter. Western Cape Province (South Africa) prevention (PMTCT) guidelines recommend a test between 32 34 weeks gestation addition to first antenatal visit (ideally <20 gestation). There are few published...
The high HIV prevalence in South Africa may potentially be shaping the local adverse drug reaction (ADR) burden. We aimed to describe and characteristics of serious ADRs at admission, during two African children's hospitals.We reviewed folders children admitted over sequential 30-day periods 2015 medical wards intensive care units each hospital. identified potential using a trigger tool developed for this study. A multidisciplinary team assessed ADR causality, type, seriousness,...
South Africa (SA) has emerged from the Millennium Development Goal era with a mixture of success and failure. The successful national scale-up prevention mother-to-child transmission HIV services increasingly efficacious antiretroviral regimens reduced rate dramatically; however, over same period there appears to have been no progress in coverage high-impact interventions for pneumonia diarrhoea, which are now leading causes under-5 mortality. SA embarked on strategy re-engineer primary...
Objectives: Infants who are HIV exposed but uninfected (HEU) compared with unexposed (HUU) have an increased risk of adverse birth outcomes, morbidity and hospitalization. In the era universal maternal antiretroviral treatment, there few insights into patterns neonatal specifically. Design: A prospective cohort study. Methods: We hospitalizations among infants were HEU ( n = 463) vs. HUU 466) born between 2017 2019 to a pregnant women from large antenatal clinic in South Africa. examined...
No abstract available
The Western Cape Pregnancy Exposure Registry (PER) was established at two public sector healthcare sentinel sites in the province, South Africa, to provide ongoing surveillance of drug exposures pregnancy and associations with outcomes.