A5076042678- Lung Cancer Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Venous Thromboembolism Diagnosis and Management
- Atomic and Subatomic Physics Research
- Respiratory and Cough-Related Research
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Monoclonal and Polyclonal Antibodies Research
- Neuroblastoma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Advanced Radiotherapy Techniques
- Respiratory viral infections research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Diagnosis and Treatment of Venous Diseases
- Ultrasound in Clinical Applications
- Protease and Inhibitor Mechanisms
- Acute Ischemic Stroke Management
- Inhalation and Respiratory Drug Delivery
- Blood properties and coagulation
- Lung Cancer Research Studies
- Erythropoietin and Anemia Treatment
- Medical Imaging and Pathology Studies
- Cardiovascular and Diving-Related Complications
NHS Greater Glasgow and Clyde
2015-2021
Beatson West of Scotland Cancer Centre
2019
Gartnavel General Hospital
2010-2018
Queen Elizabeth University Hospital
2016
University of Glasgow
2013
Western Infirmary
2009
Glasgow Royal Infirmary
1994-1999
The EarlyCDT-Lung test is a high specificity blood-based autoantibody biomarker that could contribute to predicting lung cancer risk. Here we report on the results of phase IV evaluation whether using and any subsequent CT scanning identify those at risk reduces incidence patients with stage III/IV/Unspecified diagnosis, compared standard clinical practice time study began. ECLS was randomised controlled trial 12 208 participants developing in Scotland. intervention arm received and, if...
BackgroundChronic cough and sputum production (chronic mucus hypersecretion) is a poorly described clinical feature of asthma. Our objective was to identify clinical, immunological computed tomography (CT) measures airway wall dimensions associated with these symptoms in smokers never asthma.MethodsCross-sectional data analysed from 120 Participants without history chronic hypersecretion were compared for outcomes, differential cell counts CT (wall thickness, luminal area percent...
Asthmatic smokers have poor symptom control and accelerated decline in lung function. A reduced ratio of matrix metalloproteinase (MMP)-9/tissue inhibitors metalloproteinases (TIMPs) nonsmokers with asthma has been implicated airway remodelling. We tested the hypothesis that sputum MMP-9 activity/TIMPs ratios are compared never-smokers associated function altered computed tomography (CT) measures wall dimensions. Lung function, dimensions by CT, induced concentrations (and activity) TIMP-1...
The purpose of our study was to evaluate CT findings during respiratory syncytial virus (RSV) infection in lung transplant recipients and identify sequelae.Thirty-nine scans prior to, during, following acute 10 were reviewed. Abnormalities that new from baseline observations occurred within 4 weeks diagnosis defined as acute. Chronic those present >4 after diagnosis.Findings nine patients ground-glass (seven), air-space (five), tree-in-bud (four) opacities bronchial dilatation wall...
We present the case of a 73-year-old woman who presented with clinical features Cushing's syndrome, confirmed biochemically elevated levels cortisol and adrenocorticotrophic hormone (ACTH). Petrosal venous sampling showed no ACTH gradient MRI pituitary was normal, suggesting ectopic production. In course further investigations, thoracic CT carried out to look for evidence bronchial neoplasm. Although there discrete tumour identified, revealed widespread fine nodularity in right middle lower...
Many studies have demonstrated increased coagulation activation in cancer patients and shown evidence of chronic, low-grade disseminated intravascular coagulation, although most remained asymptomatic. In general, not been screened for deep venous thrombosis (DVT). We 98 with advanced malignancy DVT using light reflection rheography. Coagulation profiles non-DVT groups were studied. found a high prevalence (50%) on screening. Overall, the had raised levels fibrinogen (66% patients), factor...
Matrix-metalloproteinase (MMP)-9 has been implicated in the pathogenesis of COPD, although its link to disease severity is unclear. The purpose study was examine relationship between assessed by lung function and computed tomography (CT) sputum MMP-9 expression, concentration activity patients with COPD.In 53 COPD subjects, smokers ex-smokers; 46 healthy controls, never smokers, we measured concentrations (ELISA) enzyme (FRET), mRNA spirometry, diffusing capacity for carbon monoxide (DLco)...
Deep venous thrombosis (DVT) is a common condition in which the clinical diagnosis notoriously inaccurate. The usually made Radiology Department by either Doppler ultrasound or conventional venography. high suspicion for DVT and availability of these imaging modalities places an ever increasing burden on radiology departments. Light reflection rheography (LRR) non-invasive technique assessing disorders. It easy quick can be performed at bedside Department. LRR was prospectively compared with...
<h3>Background</h3> EarlyCDT®-Lung Test detects autoantibodies to abnormal cell surface proteins from the early stages of lung cancer with a specificity 93%. This may allow earlier tumour detection thus altering prognosis. The primary research question is: Does using identify those at high risk cancer, followed by xray and CT scanning in test positive group, reduce incidence patients late-stage (III IV) or unclassified presentation (U) diagnosis, compared standard practice? Recruitment was...
Abstract Earlier detection of lung cancer is possible, but difficult and costly to achieve. Screening with Low Dose Computed Tomography (LDCT)scanning has been shown reduce mortality by 20-25% over the past decade uptake amongst those most likely suffer disease slow. Resource constraints a high false positive rate have also limited adoption LDCT in many health systems. Targeted screening people benefit using range biomarkers may be one way improve yield resource requirements LDCT....
<h3>Background</h3> 40% of cases lung cancer are diagnosed in patients aged 75 years and over. Comorbidities, frailty poorer tolerance therapy challenges for diagnosis management. We explored clinical outcomes survival a cohort elderly which tissue was pursued. <h3>Methods</h3> 43 older who attended between 01/11/2013 30/04/2014, where West Glasgow MDT decision made to pursue were identified from audit data. Survival reviewed at April 2015. <h3>Results</h3> Mean age 80 ± 4 yrs; 21 male/22...