A5070977147- Growth Hormone and Insulin-like Growth Factors
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Pancreatic function and diabetes
- Genetic Syndromes and Imprinting
- Obesity, Physical Activity, Diet
- Thyroid Disorders and Treatments
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Lipid metabolism and disorders
- Childhood Cancer Survivors' Quality of Life
- Birth, Development, and Health
- Diet, Metabolism, and Disease
- Sexual Differentiation and Disorders
- Adrenal Hormones and Disorders
- Pituitary Gland Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes and associated disorders
- Genetics and Neurodevelopmental Disorders
- Congenital heart defects research
- Vitamin D Research Studies
- Diabetes Management and Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Neonatal Respiratory Health Research
- Nutritional Studies and Diet
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2016-2025
Rutgers, The State University of New Jersey
2024
Hospital General de Niños Ricardo Gutierrez
2024
Monash University
2024
Royal Manchester Children's Hospital
2024
University Hospital in Motol
2024
Bambino Gesù Children's Hospital
2024
IRCCS Materno Infantile Burlo Garofolo
2024
Ospedale Maggiore
2011-2022
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2022
The reliability of provocative stimuli GH secretion in the diagnosis deficiency is still controversial. Until now, normative values response to various have not been established properly. In 472 children and adolescents with normal stature (n = 295, height SDS range -1.5 1.2) or short 177, -3.7 -1.8), we studied physical exercise, insulin-induced hypoglycemia, arginine (ARG), clonidine, levodopa, glucagon, pyridostigmine (PD), GHRH, PD + ARG GHRH. peak responses (range) were: 1) exercise:...
There is now wide consensus that, within an appropriate clinical context, GH deficiency (GHD) in adults must be shown biochemically by provocative testing of secretion and that cut-off limits have to defined for each test. Insulin-induced hypoglycemia (ITT) indicated as the test choice, severe GHD, treated with recombinant human replacement, a peak response ITT less than 3 micrograms/L. GHRH + arginine (GHRH ARG) one most promising tests alternative ITT. In fact, it has been reported potent,...
The outcomes of different types transitions young people with chronic diseases have been poorly investigated.To evaluate and compare a structured transition from the paediatric diabetes services (PDS) into adult diabetic (ADS) an unstructured one.We retrospectively investigated 62 adolescents adults type 1 discharged PDS January 1994 to 31 December 2004. Thirty-two patients (group A) were transferred ADS same hospital method (letter) 30 after transfer planned physicians B). We analysed date...
The purposes of this study were to evaluate the differences in Mediterranean diet and its components among primary secondary school children adolescents living northern Italy, associations with weight status. Adherence was assessed by KIDMED (Mediterranean Diet Quality Index) questionnaire on 669 subjects (6⁻16 years) attending five schools Novara. adherence poor 16.7%, average 63.7%, high 19.6% students. Poor more frequent than (20.7% vs. 13.7%,
On 20 February 2020, so-called Italian Patient 1 was admitted to the intensive care unit of his local hospital due a deteriorating clinical condition from SARS-CoV-2/COVID-19 infection. In Italy, COVID-19 originated handful small towns in northern Italy that were swiftly placed into lockdown. Lockdown Milan, Venice, Rimini and their provinces neighbouring cities followed on 8 March whole 9 March, when ‘#stayhome’ (#iostoacasa) executive order issued. This remained place until after Easter,...
Variations in gut microbiota might impact metabolism leading to body weight excess. We assessed the of a probiotic supplementation pediatric obesity on weight, metabolic alterations, selected microbial groups, and functionality.Cross-over, double-blind, randomized control trial (BIFI-OBESE trial; NCT03261466). 101 youths (6-18 years, Tanner stage ≥2) with insulin-resistance diet were 2 × 109 CFU/AFU/day Bifidobacterium breve BR03 (DSM 16604) B. B632 24706) (51) or placebo (50) for 8 weeks...
Objective: The aim of the study was to examine clinical characteristics, biochemical parameters, and TSH-R gene variations in children adolescents with subclinical hypothyroidism (SH) order evaluate their pattern distribution SH. Patients: We enrolled 88 patients, each having at least two TSH measurements above upper limit reference range normal free thyroid hormones negative autoantibodies. Main Outcome Measures: Clinical characteristics included height, weight, family history diseases,...
Classical provocative stimuli of GH secretion such as insulin-induced hypoglycaemia, arginine, clonidine, glucagon and levodopa have been widely used in clinical practice for approximately 30 years. On the other hand, last 10 years new potent proposed, but an extensive comparison with classical ones has rarely performed, at least adults. In order to compare GH-releasing activity old secretion, define normative values response, 178 normal adults (95 males, 83 females; age range: 20-50 years,...
Objective : A consensus exists that severe growth hormone deficiency (GHD) in adults is defined by a peak GH response to insulin-induced hypoglycemia (insulin tolerance test, ITT) of less than 3 μg/l based on cohort subjects with mean age 45 years. Design and methods By considering one the following two criteria for diagnosis probable permanent GHD, i.e. severity GHD (suggested presence multiple pituitary deficiencies (MPHD)) or magnetic resonance (MR) imaging identification structural...
Objective To define the appropriate diagnostic cut-off limits for GH response to GHRH+arginine (ARG) test and IGF-I levels, using receiver operating characteristics (ROC) curve analysis, in late adolescents young adults. Design methods We studied 152 patients with childhood-onset organic hypothalamic–pituitary disease (85 males, age (mean± s.e.m. ): 19.2±0.2 years) 201 normal as controls (96 age: 20.7±0.2 years). Patients were divided into three subgroups on basis of number other pituitary...
Key circulating molecules that link vitamin D (VD) to pediatric obesity and its co-morbidities remain unclear. Using a proteomic approach, our objective was identify key in obese children dichotomized according 25OH-vitamin (25OHD) levels. A total of 42 (M/F = 18/24) were divided their 25OHD3 levels into deficient (VDD; n 18; 25OHD<15 ng/ml) or normal subjects (NVD; 24; >30 ng/ml). Plasma analyses by two dimensional (2D)-electrophoresis performed at baseline all subjects. VDD underwent 12mo...
Our aim was to evaluate adherence the Mediterranean diet (MedDiet) among children and adolescents with type 1 diabetes (T1D) in relation metabolic control. Adherence MedDiet assessed Diet Quality Index (KIDMED) questionnaire physical activity by International Physical Activity Questionnaire for Adolescent (IPAQ-A) on 65 subjects (32 males, 9-18 years) T1D. Clinical evaluation performed (standardized body mass index (BMI-SDS), hemoglobin A1C (HbA1c), continuous glucose monitoring metrics when...
Previous investigations on the ghrelin gene reported three common polymorphisms (Arg51Gln, Leu72Met, and Gln90Leu), but their role in overweight obese individuals remains to be clarified.To ascertain whether these genetic variants could influence secretion play a part predisposing earlier onset of obesity or modulating phenotype childhood.Mutational analysis entire total acylated plasma determinations were performed 81 children adolescents (46 35 overweight: Ob/Ow). We also recruited 168...
Within an appropriate clinical context, severe GH deficiency (GHD) in adults has to be defined biochemically by provocative testing of secretion. Patients with childhood-onset GHD need retesting late adolescence or young adulthood verify whether they have continue recombinant human treatment. GHRH + arginine (GHRH+ARG) is the most reliable alternative insulin-induced hypoglycemia test (ITT) as a for diagnosis adulthood, provided that cut-off limits are assumed (normal limits, 16.5 μg/L 3rd...