A5051238435- Knee injuries and reconstruction techniques
- Shoulder Injury and Treatment
- Orthopaedic implants and arthroplasty
- Osteoarthritis Treatment and Mechanisms
- Shoulder and Clavicle Injuries
- Total Knee Arthroplasty Outcomes
- Lower Extremity Biomechanics and Pathologies
- Tumors and Oncological Cases
- Inflammasome and immune disorders
- Infrared Thermography in Medicine
- Cardiac tumors and thrombi
- Sports injuries and prevention
- Orthopedic Surgery and Rehabilitation
- Trauma and Emergency Care Studies
- Melanoma and MAPK Pathways
- Gout, Hyperuricemia, Uric Acid
- Anesthesia and Pain Management
- Sarcoma Diagnosis and Treatment
- Injury Epidemiology and Prevention
- Vascular Malformations and Hemangiomas
- Bone Tumor Diagnosis and Treatments
- Traffic and Road Safety
- Cutaneous Melanoma Detection and Management
- Spondyloarthritis Studies and Treatments
- Bone and Joint Diseases
Singapore General Hospital
2010-2025
Uric acid may activate an innate immune response in osteoarthritis (OA), contributing to disease pathology and progression. We evaluated the effectiveness of colchicine on pain function symptomatic knee OA (KOA) underlying mechanism action.Colchicine symptoms inflammation modification (COLKOA) was a double-blind, placebo-controlled, randomized trial comparing 16 weeks treatment with 0.5 mg twice-daily oral placebo for (KOA). The primary endpoint ≥30% improvement total Western Ontario...
We aimed to evaluate the relationship between patient expectations and outcomes after knee arthroplasty (KA) in an Asian population Singapore. recruited consecutive patients with severe osteoarthritis (KOA) scheduled for KA. Pre-operatively, provided socio-demographic data completed Hospital Special Surgery Knee Replacement Expectations Survey (HSS-KRES) baseline pre-operative Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) pain function. Telephone interviews were...
ObjectivesPain sensitization could be a risk factor for poor outcomes after knee replacement surgery (KR) osteoarthritis (KOA). We aimed to evaluate the association between pre-operative central and peripheral pain measured using digital pressure algometer KR outcomes.MethodsConsecutive patients with severe KOA listed were recruited. Sociodemographic symptoms data collected prior surgery. Pre-operative thresholds (PPTs) at index forearm. Patient satisfaction 6 12 months was assessed 4-point...
Personal mobility devices (PMDs), such as electronic scooters or motorised bicycles, are efficient modes of transportation. Their recent popularity has also resulted in an increase PMD-related injuries. We aimed to characterise and compare the nature injuries sustained by PMD users bicycle riders.This retrospective study compared injury patterns among users. 140 patients were admitted between November 2013 September 2018. Parameters studied included patients' demographics (e.g. age, gender...
To quantify bone-nail fit in response to varying nail placements by entry point translation straight antegrade humeral nailing using three-dimensional (3D) computational analysis CT scans of ten cadaveric humeri were processed 3D Slicer obtain models the cortical and cancellous bone. The bone was divided into individual slices each consisting 2% length (L) with centroid slice determined. represent nail, a rod two cylinders diameters 9.5mm 8.5mm 0.22L mm 0.44L respectively joined at one end...
To analyse bone stresses in humerus-megaprosthesis construct response to axial loading under varying implant lengths proximal humeral replacement following tumour excision. CT scans of 10 cadaveric humeri were processed 3D Slicer obtain three-dimensional (3D) models the cortical and cancellous bone. Megaprostheses body (L) modelled FreeCAD geometry. Four FE models: group A consisting intact bone; groups B (L=40mm), C (L=100mm) D (L=120mm) comprising constructs created. Isotropic linear...