A5060769251- Aortic aneurysm repair treatments
- Coronary Interventions and Diagnostics
- Elasticity and Material Modeling
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Vascular Procedures and Complications
- Sarcoma Diagnosis and Treatment
- Dental Radiography and Imaging
- Cardiac Valve Diseases and Treatments
- Dental materials and restorations
- Soft tissue tumor case studies
- Orthopaedic implants and arthroplasty
- Tumors and Oncological Cases
- Cardiovascular Health and Disease Prevention
- dental development and anomalies
- Connective tissue disorders research
- Bone Tumor Diagnosis and Treatments
- Vascular Anomalies and Treatments
- Oral microbiology and periodontitis research
- Histiocytic Disorders and Treatments
- Mathematical Biology Tumor Growth
- Cardiac tumors and thrombi
- Infectious Aortic and Vascular Conditions
The University of Texas at Dallas
2016-2025
University Hospital Bonn
2012-2024
Centre Hospitalier Universitaire de Besançon
2008-2020
Université de franche-comté
2017-2020
Institut de Recherche sur les Phénomènes Hors Équilibre
2010-2014
Château Gombert
2014
Food and Drug Administration
2013
Center for Devices and Radiological Health
2013
Centre National de la Recherche Scientifique
2010-2012
Institut Cardiovasculaire Paris Sud
2010
A stent is a device designed to restore flow through constricted arteries. These tubular scaffold devices are delivered the afflicted region and deployed using minimally invasive techniques. Stents must have sufficient radial strength prop diseased artery open. The presence of can subject abnormally high stresses that trigger adverse biologic responses culminating in restenosis. primary aim this investigation was investigate effects varying “design parameters” on stress field induced normal...
Solitary fibrous tumor (SFT) is a rare, non-hereditary soft tissue sarcoma thought to originate from fibroblastic mesenchymal stem cells. The etiology of SFT be due an environmental intrachromosomal gene fusion between NGFI-A-binding protein 2 (NAB2) and signal transducer activator 6 (STAT6) genes on chromosome 12, wherein the activation domain STAT6 fused with DNA-binding NAB2 resulting in oncogenesis SFT. All NAB2-STAT6 variations discovered SFTs contain C-terminal transcript, thus can...
Purpose: To examine the solid mechanical effects of varying stent design and atherosclerotic plaque stiffness on biomechanical environment induced in a diseased artery wall model.Methods: Computational modeling techniques were employed to investigate final radius lumen stresses after implantation.Two designs studied (one stiff one less stiff).The stenotic was modeled as an axisymmetrical vessel with 20% stenosis by diameter.The material properties tissue models varied.Atherosclerotic plaques...
Background: Sculpted physical models and castings of the anatomy cleft lip palate are used for parent, patient, trainee education conditions. In this study, we designed a suite digital 3-dimensional (3D) with additive manufacturing techniques patient education. Methods: CT scans subjects isolated palate, unilateral bilateral control were obtained. Soft tissue bony structures segmented reconstructed into 3D models. The oral soft tissues overlying manually molded silicone putty scanned using...
The purpose of this study was to compare the stress distributions in teeth treated through minimally invasive access (MIA) designs those traditional straight-line and their relationship final restoration using three-dimensional finite element analysis (FEA).Four FEA models an extracted mandibular first molar were constructed. An intact model served as control, whereas other three prepared with either MIA or access. Simulated composite fillings without a simulated gold crown applied models,...
Cancers, especially fusion oncoprotein (FO)-driven hematological cancers and sarcomas, often develop from a low number of key mutations. Solitary Fibrous Tumor (SFT) is rare mesenchymal tumor driven by the NAB2-STAT6 oncofusion gene. Currently, treatment options for SFT remain limited, with anti-angiogenic drugs providing only partial responses an average survival two years. To address this challenge, we constructed cell models harboring specific transcripts using CRISPR (Clustered Regularly...
How much and how the thrombus supports wall of an abdominal aortic aneurysm (AAA) is unclear. While some previous studies have indicated that lacks mechanical integrity to support load compared with wall, others shown removing in computational AAA models drastically changes stress. Histopathological properties vary through thickness it can be porous. The goal this study explore variations properties, including ability isolate pressure from incomplete attachment, their effects on stress,...
A new experimental setup has been implemented to precisely measure the deformations of an entire model abdominal aortic aneurysm (AAA). This addresses a gap between computational and models AAA that have aimed at improving limited understanding development rupture. The validation from approaches by lack consideration large varied AAAs undergo in response physiologic flow pressure. To address issue experimentally validating these calculated deformations, stereoscopic imaging system utilizing...
Solitary fibrous tumor (SFT) is a rare soft-tissue sarcoma. This nonhereditary cancer the result of an environmental intrachromosomal gene fusion between NAB2 and STAT6 on chromosome 12, which fuses activation domain with repression NAB2. Currently there not approved chemotherapy regimen for SFTs. The best response available pharmaceuticals partial or stable disease several months. purpose this study to investigate potential RNA-based therapies treatment Specifically, in vitro SFT cell...
Recent literature indicates that the long-term success of dental implants is, in part, attributed to how crowns are attached their associated implants. The commonly utilized method for crown attachment – cementation, has been criticized because recent links between residual cement and peri-implant disease. Residual extrusion from crown-abutment margins post-crown seating is a growing concern. This study aimed at (1) identifying key abutment features, which would improve flow characteristics,...
Over the past two decades, increase in prevalence of cardiovascular diseases and limited availability autologous blood vessels saphenous vein grafts have motivated development tissue-engineered vascular (TEVGs). However, compliance mismatch poor mechanical properties TEVGs remain as major issues that need to be addressed. Researchers investigated role various culture conditions conditioning deposition orientation collagen fibers, which are key structural components wall; however, intrinsic...
Despite advancements in early detection and treatment, atherosclerosis remains the leading cause of death across all cardiovascular diseases (CVD). Biomechanical analysis atherosclerotic lesions has potential to reveal biomechanically instable or rupture-prone regions. Treatment decisions rarely consider biomechanics stenosed lesion due in-part difficulties obtaining this information a clinical setting. Previous 3D FEA approaches have incompletely incorporated complex curvature arterial...
False aneurysms of the superficial temporal artery (STA) are rare and usually occur after a direct trauma to one its branches. It is characterized by local rupture wall. The diagnosis made clinical history examination. treatment surgery.Two patients, 20-year-old man an 82-year-old man, were referred with pulsatile mass respectively in frontal area having evolved for several weeks. was on (history important clue) examination (compression proximal STA should reduce pulsation) confirmed...
Abstract Numerical simulations of coupled hemodynamics and leukocyte transport adhesion inside coronary arteries have been performed. Realistic artery geometries obtained for a set four patients from intravascular ultrasound angiography images. The numerical model computes unsteady three-dimensional blood concentration in the blood. Wall-shear stress dependent is also computed through agent-based modeling rules, fully to transport. results good correlation with clinical data. Regions where...