A5035698330- Cancer-related Molecular Pathways
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Glycosylation and Glycoproteins Research
- Tryptophan and brain disorders
- Cell death mechanisms and regulation
- Cancer Research and Treatments
- Bladder and Urothelial Cancer Treatments
- Bipolar Disorder and Treatment
- Stress Responses and Cortisol
- Protein Degradation and Inhibitors
- RNA Interference and Gene Delivery
- Mitochondrial Function and Pathology
- Neurotransmitter Receptor Influence on Behavior
- Autophagy in Disease and Therapy
- Alzheimer's disease research and treatments
- Schizophrenia research and treatment
- Wnt/β-catenin signaling in development and cancer
- Microtubule and mitosis dynamics
- Treatment of Major Depression
- Neuroblastoma Research and Treatments
- Melanoma and MAPK Pathways
- Hereditary Neurological Disorders
- Stochastic Gradient Optimization Techniques
- Nerve injury and regeneration
Bali Psychiatric Center
2023
Leo Pharma (Australia)
2019
Kaohsiung Armed Forces General Hospital
2011-2018
National Sun Yat-sen University
2011-2017
Kaohsiung Medical University
2012-2016
Kaohsiung Medical University Chung-Ho Memorial Hospital
2012-2016
Education Development Center
2015
Children's Hospital at Westmead
2009
Mianyang Central Hospital
2009
Multiple phosphorylation sites of Drp1 have been characterized for their functional importance. However, the consequence GSK3beta-mediated remains unclear. In this report, we pinpointed 11 Serine/Threonine spanning from residue 634∼736 GED domain and robustly confirmed Ser693 as a novel GSK3beta site. Our results suggest that at does cause dramatic decrease GTPase activity; in contrast, appears not to affect inter-/intra-molecular interactions. After identifying site, also determined K679 is...
Bcl2L12 as a new member of the Bcl2 family, which contains BH2 domain and shares lower amino acid similarity with other family proteins. is reported to be involved in apoptosis regulation, but this role remains controversial different cancer type. Temozolomide (TMZ) currently used intervene glioma multiforme (GBM), an acquired chemotherapeutic resistance maybe occurred due undesired autophagy. Previous studies uncovered that may interact Bcl-xL harbor BH3-like domain. Therefore, we...
BCL2L12 has been reported to be involved in post-mitochondrial apoptotic events glioblastoma, but the role of BCL2L12A, a splicing variant BCL2L12, remains unknown. In this study, we showed that and BCL2L12A were overexpressed glioblastoma multiforme (GBM). Large-scale yeast two-hybrid screening was GSK3b binding partner testis cDNA library. Our data demonstrated interacts with not whose C terminus lacks region. We found BCL2L12153–191 fragment located outside C-terminal BH2 motif is...
Neuropathic pain due to peripheral nerve injury may be associated with abnormal central activity. Glial cell-line-derived neurotrophic factor (GDNF) can help attenuate neuropathic in different animal models of injury. However, whether GDNF ameliorate the spinal cord dorsal horn (SCDH) constriction-induced remains unknown. We investigated therapeutic effects adenoviral-mediated on behaviors, microglial activation, pro-inflammatory cytokine expression and programmed cell death a chronic...
We previously reported that Aurora-A and the hNinein binding protein AIBp facilitate centrosomal structure maintenance contribute to spindle formation. Here, we report also interacts with Plk1, raising possibility of functional similarity Bora, which subsequently promotes Aurora-A-mediated Plk1 activation at Thr210 as well Thr288. In kinase assays, acts not only a substrate but positive regulator both Plk1. However, functions negative block phosphorylation mediated by These findings suggest...
A growing tendency for community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) to be involved in nosocomial infections was reported. The predominance of SCCmec type IV or V CA-MRSA soft tissue infection has also been indicated Northern Taiwan. To establish basic information about the molecular characteristics MRSA our region, a total 102 isolates were collected and characterized by an array typing methods. Healthcare-associated (HA-MRSA) found more resistant levofloxacin...
BH3 domains, classified initially as BCL2 homology participate in both apoptosis and autophagy. Beclin‑1 contains a domain, which is required for binding to antiapoptotic homologs BCL2‑mediated inhibition of BCL2‑like 12 (BCL2L12) also harbors BH3‑like residues long LXXXAE/D motif. In yeast two‑hybrid system performed the present study, BCL2L12 shared similar partnerships homologs, such Beclin‑1. addition, this domain was involved anti‑apoptosis drug‑induced autophagy glioma cell lines....
<i>Introduction:</i> p53 codon 72 polymorphism has been reported to be associated with bladder cancer incidence, progression and prognosis, but the association is still under debate. A tentative model was constructed evaluate between cancer. <i>Subjects Methods:</i> In this study, a total of 554 participants were enrolled. The genotyping carried out using PCR-RFLP DNA direct sequencing. <i>Results:</i> genotype distribution significantly different patients...
Abstract Dysregulated centrosomal expression has been observed in high grade gliomas. Thus, this study aimed to examine the of Aurora family kinase and various proteins, including centrin, γ‐tubulin, hNinein isoforms, human brain tumors, 29 meningiomas, 34 astrocytomas, 6 pituitary adenomas, metastatic tumors. mRNA was evaluated using reverse transcription polymerase chain reaction. The role isoform cell differentiation assessed BrdU‐treated IMR‐32 cells. Differential proteins tumors lines...
Objective To investigate the distribution of pathogenic bacteria in patients injuries combined with infection after May 12 Wenchuan Earthquake and drug resistance thereof. Methods Bacterial culture identification were conducted on 139 clinical specimens from 108 open infection. Drug-sensitive test was carried out by Kirby-Bauer method isolated strains. Results Ninety-six stains isolated,79.86% them infected wound secretion 58.33% thee department orthopedics. The high isolation rates included...