To evaluate the effect of adjuvant chemotherapy in patients with local-regional nasopharyngeal carcinoma (NPC) (squamous or undifferentiated) complete remission at end curative radiotherapy (RT) 229 were randomized from 1979 to 1983 a multicenter study no further therapy (116 patients) combination vincristine, cyclophosphamide, and Adriamycin (doxorubicin; Adria Laboratories, Columbus, OH) (VCA) for six monthly cycles (113 patients). The RT + VCA groups well balanced median age (50 v 49...

Purpose: Prognosis of patients with advanced oral cavity cancer is worth improving. Chemotherapy has been reported to be especially active in tumors. Here we repeat the results a randomized, multicenter trial enrolling resectable, stage T2–T4 (> 3 cm), N0–N2, M0 untreated, squamous cell carcinoma cavity. Patients and Methods: were randomly assigned three cycles cisplatin fluorouracil followed by surgery (chemotherapy arm) or alone (control arm). In both arms, postoperative radiotherapy...

Abstract A series of 618 patients with neck dissections were performed in 455 consecutively admitted head and carcinomas at the Istituto Nazionale Tumori, Milan, from 1976 to 1978. Clinical pathologic node factors considered an effort correlate lymph involvement prognosis. Actuarial survival decreased increase size nodes, although no significant difference was found for all categories prognosis poor when nodes > 5 cm and/or hypomobile (33%, 5‐year survival). The presence histologically...

Abstract Honey bee ( Apis mellifera ) colony loss is a widespread phenomenon with important economic and biological implications, whose drivers are still an open matter of investigation. We contribute to this line research through large-scale, multi-variable study combining multiple publicly accessible data sources. Specifically, we analyzed quarterly covering the contiguous United States for years 2015-2021, combined on honey status stressors, weather data, land use. The different...

Abstract Sixty‐six patients, surgically treated for head and neck cancer free of disease, were interviewed at the outpatient clinic from 6 months to 8 years after surgery. The patients divided by physician into two groups, according patients' degree disfigurement, i.e., minor (24 36%, disfigurement group = MDG) or extensive (42 64%, EDG). Subsequently, with close‐ended questions. following subjective aspects assessed: self‐image; relationship partner, family, friends; overall impact therapy....

The natural history of 292 consecutive cases reticulum cell sarcoma and lymphosarcoma Waldeyer's ring the survival rate after radiotherapy are reported. In our institute since 1928 from 30 to 35% pharyngeal neoplasms have been lymphomas, these 55% sarcomas, 21% lymphosarcomas, 1% Hodgkin's disease. This high incidence may probably be ascribed fact that in all malignant irrespective clinical presentation, a systematic biopsy whole was carried out. Pharyngeal lymphomas were confined 19.6%...

A total of 225 consecutive untreated patients with lymphoreticular sarcomas primary involvement Waldeyer's ring was evaluated (151 without lymphography and 74 lymphography). On admission, the anatomical distribution growth within as follows: tonsil, 40%; nasopharynx, 27.5%; base tongue, 2.7%; soft palate, oropharynx, 0.9%; other sites, 26.2%. In group studied lymphography, disease confined to in 22.5% cases had spread cervical nodes 62.3% distant 15.2%. more recently these figures were...

• We evaluate the 3-year result of 145 oral leukoplakias operated on by outpatient carbon dioxide laser surgery at Istituto Nazionale Tumori, Milan, Italy. The surgical technique that was used consisted excision in 140 patients and vaporization 5 patients. Cancer found 14 out who underwent (10%). In analysis disease-free survival rate unfavorable pattern events, only 131 with benign postoperative histologic diagnosis were considered. Fifty-eight developed events. probabilities remaining free...

This letter formally proves the statistical inconsistency of Allan variance-based estimation latent (composite) model parameters. issue has not been sufficiently investigated and highlighted since it is a technique that still being widely used in practice, especially within engineering domain. Indeed, among others, this method frequently for inertial sensor calibration, which often deals with time series models practitioners these domains are unaware its limitations. To prove method, we...

Abstract We have retrospectively evaluated a series of 27 consecutive children observed from 1965 to 1980 with nasopharyngeal carcinoma (NPC). Histological diagnosis in each patient was undifferentiated type (UCNT) prominent lymphocytic infiltration. Regional node involvement present 26 patients and two presented distant metastases. Twenty evaluable primary tumor or without positive cervical nodes underwent radiotherapy (RT) uniform criteria technique. Adjuvant cyclophosphamide (CPM)...

Several epidemiologic studies have shown that oral cancer develops among individuals with a prior diagnosis of an premalignant lesion. Canceration chance in these patients is 17 %, the greatest rate occuring second year observation. Based on this data, since 1981, 92 leucoplakias been treated by out-patient laser surgery at Istituto Nazionale Tumori Milano. The therapeutic technique was excision to obtain specimen for histology. Two groups were distinguished according diagnostic procedure....

A retrospective comparison of radical and conservative technique for neck dissection in cancer the larynx was made, starting from analysis 98 patients operated on with procedure (128 cervical fields at risk recurrence) Istituto Nazionale Tumori Milan. Furthermore, a series 162 selected more than 500 dissections performed past to set up as comparable possible far several parameters were concerned. No significant difference found between regard incidence recurrences operative field, either...

Highlights Phosphorus and nitrogen in soil plants varied during the growing season across cornfield. Spatial variability nutrients caused spatial plant growth crop yield Hydrological characteristics hydraulic properties were responsible for nutrients. Need to consider delineating management zones before adopting practices. Abstract . The adoption of precision agricultural practices Alabama has been increasing recent years. Although challenging, understanding nutrient fields is important...

Western honey bees (Apis mellifera) have experienced elevated rates of colony loss over the past decade. Past studies attempted to determine what factors are behind these losses; however, few considered effects environmental variables; key drivers in ecological systems. Existing investigations were conducted at local spatial scales, small geographic areas, and failed measure how variables may influence differently across space. Here, we sought ability explain bee winter contiguous U.S. a...

Report on a case of primary basal cell carcinoma in the skin eyelid. Only bone metastases were detected after many local recurrences. The associated with myelophthisic anemia, leukoerythroblastosis peripheral blood and extramedullary hepatic hemopoiesis; these findings have not been reported before.

A series of 113 patients operated on in the period 1980-1989 for a neck recurrence from head and cancer was studied. All had no other evidence disease. The male/female ratio 93/20, median age 58 years (range 28-87). Previous treatment consisted surgery (SG) +/- radiotherapy (RT) 81 (SG group) only RT 32 (RT group): 59 cases presented relapse treated 54 contralateral side. but one recurrences were SG group. Ten lost to follow-up. observed 5-year survival rate whole 29.2% (95% confidence...