A5092262779- Single-cell and spatial transcriptomics
- Gene Regulatory Network Analysis
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Genomics and Phylogenetic Studies
- Gene expression and cancer classification
- MicroRNA in disease regulation
- RNA Research and Splicing
Centre National de la Recherche Scientifique
2023-2024
Université Paris Cité
2023-2024
Université Paris Sciences et Lettres
2023-2024
Institut Pasteur
2023-2024
Inserm
2023-2024
Institut de Biologie de l'École Normale Supérieure
2023-2024
University Hospital Heidelberg
2023
Heidelberg University
2023
Motivation The molecular identity of a cell results from complex interplay between heterogeneous layers. Recent advances in single-cell sequencing technologies have opened the possibility to measure such layers regulation. Results Here, we present HuMMuS, new method for inferring regulatory mechanisms multi-omics data. Differently state-of-the-art, HuMMuS captures cooperation biological macromolecules and can easily include additional We benchmarked with respect state-of-the-art on both...
Cells regulate their functions through gene expression, driven by a complex interplay of transcription factors and other regulatory mechanisms that together can be modeled as networks (GRNs). The emergence single-cell multi-omics technologies has the development several methods integrate transcriptomics chromatin accessibility data to infer GRNs. While these provide examples utility in discovering new interactions, comprehensive benchmark evaluating mechanistic predictive properties well...
Abstract The molecular identity of a cell results from complex interplay between heterogeneous layers. Recent advances in single-cell sequencing technologies have opened the possibility to measure such layers regulation. Here, we present HuMMuS, new method for inferring regulatory mechanisms multi-omics data. Differently state-of-the-art, HuMMuS captures cooperation biological macromolecules and can easily include additional We benchmarked with respect state-of-the-art on both paired...