A5090677917- Cerebral Palsy and Movement Disorders
- Musculoskeletal pain and rehabilitation
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Muscle activation and electromyography studies
- Balance, Gait, and Falls Prevention
- Cardiac Arrest and Resuscitation
- Reliability and Agreement in Measurement
- Shoulder Injury and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Spinal Fractures and Fixation Techniques
- Sports Performance and Training
- Chemical Synthesis and Analysis
- PARP inhibition in cancer therapy
- Health, Environment, Cognitive Aging
- Autoimmune and Inflammatory Disorders Research
- Health Systems, Economic Evaluations, Quality of Life
- Sinusitis and nasal conditions
- Venomous Animal Envenomation and Studies
- Reproductive Physiology in Livestock
- Cellular transport and secretion
- Erythrocyte Function and Pathophysiology
- Synthetic Organic Chemistry Methods
- Clinical Reasoning and Diagnostic Skills
C4X Discovery (United Kingdom)
2014-2024
University of East Anglia
2003-2018
University of Strathclyde
2007-2014
Norwich Research Park
2014
AstraZeneca (United Kingdom)
2012
Norfolk and Norwich University Hospital
2011
Orthopaedic Research
2011
University Hospital Foundation
2011
The University of Melbourne
2009
University of Sheffield
2005
Objective: To develop a behavioural assessment based on observations of patients recovering after severe head injury whereby data could be collected by observation and testing everyday tasks. Design: A prospective observational study cohort 88 consecutive hospital admissions with injury. Setting: Two district general hospitals in the UK. Patients: Eighty-eight traumatic Ages ranged from 14 to 67 years, mean coma duration was days post amnesia (PTA) 56 days. Results: Fifty-eight items...
Poly(ADP-ribose) glycohydrolase (PARG) is the only enzyme known to catalyse hydrolysis of O-glycosidic linkages ADP-ribose polymers, thereby reversing effects poly(ADP-ribose) polymerases. PARG deficiency leads cell death whilst depletion causes sensitisation certain DNA damaging agents, implicating as a potential therapeutic target in several disease areas. Efforts develop small molecule inhibitors activity have until recently been hampered by lack structural information on PARG. We used...
Over 1000 accurately defined and validated experimental long-range proton-carbon (nJCH) proton-proton (nJHH) scalar coupling constants, with assigned 1H/13C chemical shifts their corresponding 3D structures are reported for fourteen...
The sorting nexin (SNX) family of proteins is characterized by sequence-related phox homology (PX) domains. A minority PX domains bind with high affinity to phosphatidylinositol 3-phosphate [PI(3)P], whereas the majority exhibit low that insufficient target them vesicles. SNX1 located on endosomes, but its domain fails localize in vivo. NMR structure reveals an overall fold similar high-affinity However, (PI) binding pocket incomplete; regions are well defined highly mobile SNX1. Some this...
This phase 1 exploratory study aimed to establish proof of concept the effects dynamic elastomeric fabric orthoses (DEFOs) on gait children with spastic diplegic cerebral palsy. Replicated single case experiments employing an ABA methodology were carried out eight subjects (median age 5.5 years, range 3–13 years; 4 girls/boys) utilizing quantitative/qualitative data collection. Outcome measures were: Ten metre walking test (10MWT); physiological cost index (PCI); visual analogue scale (VAS)...
GPR103, a G-protein coupled receptor, has been reported to have orexigenic properties through activation by the endogenous neuropeptide ligands QRFP26 and QRFP43. Recognizing that central administration of QRFP43 increases high fat food intake in rats, we decided investigate if antagonists GPR103 could play role managing feeding behaviors. Here present development new series pyrrolo[2,3-c]pyridines as small molecule with affinity, drug metabolism pharmacokinetics safety parameters suitable...
Primary objective: The aim of this study was to assess the effect a dynamic lycra® orthosis in management upper limb paresis late stage stroke patient.Research design: A single case experiment, adopting 3-phase ABA withdrawal design (without follow-up), ∼6-weeks per phase, intervention being delivered middle/B phase.Method and procedures: Assessment arm function carried out on weekly basis for 18-weeks, using battery tests. subject prescribed tailor-made which worn daily during middle phase...
Functional Strength Training (FST) could enhance recovery late after stroke. The aim of this study was to evaluate the feasibility a subsequent fully powered, randomized controlled trial. designed as randomized, observer-blind Both interventions were provided for up one hour day, four days week, six weeks. Evaluation points before randomization (baseline), weeks intervention (outcome), and thereafter (follow-up). took place in participants' own homes. Participants (n = 52) mean 24.4 months...
Building block methodology from trifluoroethanol and ring-closing metathesis using a Fürstner modification of Grubbs' conditions allows the rapid synthesis novel difluorinated cyclooctenones.
Purpose: People with multiple sclerosis (MS) commonly experience muscle weakness which limits their ability to stand. Supported standing may minimise the secondary complications of prolonged sitting but evidence for this is scarce. This study investigated effects regular in an Oswestry frame on some immobility and explored lived standing. Methods: Nine people MS participated a mixed-methods over 48 weeks. Single-case experiments were used. Outcomes included: Amended Motor Club Assessment,...
In Brief Across a variety of patient groups, the painful subluxed shoulder is notoriously difficult clinical problem to manage. A number treatment strategies have been proposed, which generally mixed success. Dynamic Elastomeric Fabric Orthoses (DEFOs) represent an emerging strategy for movement and postural control problems. Their use in management has not, however, previously documented. The case report provides brief account young man with as result manual handling injury. At end initial...
Purpose: The purpose of this qualitative study was to explore how stroke patients with unilateral spatial neglect experience; (a) performance in activities daily living; (b) alterations bodily perceptions; and (c) personal hopes expectations, looking at the period between onset discharge from inpatient rehabilitation.Materials methods: We conducted individual semi-structured interviews 7 (5 men, 2 women, mean age 69 years) consecutively sampled participants. All were transcribed verbatim...
Rationale Functional Strength Training may enhance motor function of people who are more than six months post stroke. Aims to evaluate the clinical efficacy enhancing upper and lower limb with FST explore participants' views (expectations experiences) FST, determine what cost-effectiveness data collect in a subsequent Phase III trial. Design Randomized, observer-blind trial embedded qualitative investigation ( n = 6, purposive sampling). Study Participants 58), five years after stroke...