A5078295069- BRCA gene mutations in cancer
- Cancer survivorship and care
- Family Support in Illness
- Childhood Cancer Survivors' Quality of Life
- Global Cancer Incidence and Screening
- Palliative Care and End-of-Life Issues
- Nutrition, Genetics, and Disease
- Patient-Provider Communication in Healthcare
- Cancer-related cognitive impairment studies
- Ethics in Clinical Research
- Health Systems, Economic Evaluations, Quality of Life
- Health Literacy and Information Accessibility
- Cancer Genomics and Diagnostics
- Empathy and Medical Education
- Healthcare professionals’ stress and burnout
- Prenatal Screening and Diagnostics
- Innovations in Medical Education
- Mental Health via Writing
- Mental Health and Patient Involvement
- Genomics and Rare Diseases
- Social Media in Health Education
- Identity, Memory, and Therapy
- Advances in Oncology and Radiotherapy
- Art Therapy and Mental Health
- Diversity and Career in Medicine
Georgetown University
2016-2025
Georgetown Lombardi Comprehensive Cancer Center
2014-2024
Georgetown University Medical Center
2015-2024
Office of Diversity and Inclusion
2024
Hereditary Disease Foundation
2019-2023
Dean College
2023
Sidney Kimmel Comprehensive Cancer Center
2021
Intarcia Therapeutics (United States)
2020
Georgetown-Howard Universities Center for Clinical and Translational Science
2019
MedStar Georgetown University Hospital
2016-2018
Although guidelines recommend in-person counseling before BRCA1/BRCA2 gene testing, genetic is increasingly offered by telephone. As genomic testing becomes more common, evaluating alternative delivery approaches salient. We tested whether telephone of BRCA1/2 was noninferior to delivery.Participants (women age 21 85 years who did not have newly diagnosed or metastatic cancer and lived within a study site catchment area) were randomly assigned usual care (UC; n = 334) (TC; 335). UC...
Social cognitive theory (SC) provides a theoretical framework to evaluate improved quality-of-life (QOL) outcomes through interventions with cancer patients To assess whether inclusion of SCT components predicted better outcomes, focused comparisons were used integrate results from 38 randomized studies. Interventions more had significantly larger effect sizes than studies fewer or no for the overall analysis (Z = 3.72, p < .01). Subanalyses affective, social, objective physical outcome, and...
Abstract BACKGROUND: For BRCA1/BRCA2 gene testing to benefit public health, mutation carriers must initiate appropriate risk management strategies. There has been little research examining the long‐term use and prospective predictors of full range behaviors among women who have undergone BRCA1/2 testing. We evaluated uptake risk‐reducing mastectomy (RRM), bilateral salpingo‐oophorectomy (RRBSO), chemoprevention, cancer screening at a mean 5.3 years after METHODS: The study participants...
As genetic counseling and testing become more fully integrated into clinical care, alternative delivery models are increasingly prominent. This study examines predictors of for hereditary breast/ovarian cancer among high-risk women in a randomized trial in-person versus telephone-based counseling.Methods include multivariable logistic regression interaction analyses.Of the 669 participants, 600 completed 523 received test results. previously reported, participants to telephone were...
Accreditation standards are at the forefront of evolving healthcare systems, setting metrics for high-quality care. Healthcare outcomes (health, experience, cost, provider satisfaction/burn out) becoming mutual goals patient, provider, payer, and system. Achieving in cancer care necessitates collaboration among interdisciplinary teams clinical providers, administrators, patient advocates, caregivers, researchers. Dissemination implementation science provides necessary frameworks to organize...
Objectives: Youth are increasingly at risk for contracting HIV infection, and community-level interventions needed to reduce behavioral risk. Design: A randomized, controlled, multi-site intervention trial was undertaken with adolescents living in 15 low-income housing developments five US cities. Methods: Baseline (n = 1172), short-term follow-up 865), long-term 763) assessments were conducted among adolescents, ages 12–17, all developments. The randomly assigned equal numbers each of three...
Abstract The physical and psychosocial ‘health’ behaviors of cancer patients have become a more pressing issue as 5‐year survival rates continue to rise. This study investigated: (a) the extent positive change in four two health behaviors, (b) role predictors (drawn from theories Social Cognitive Processing optimism) behavior after diagnosis treatment, (c) possible influence social desirability reports change. showing greatest was time spent reflecting on life priorities; that least likely...
Abstract Background: Numerous studies have documented the short-term impact of BRCA1/BRCA2 (BRCA1/2) testing; however, little research has examined long-term testing. We conducted first prospective study psychosocial outcomes in a U.S. sample women who had BRCA1/2 Methods: Participants were 464 underwent genetic testing for mutations. Prior to testing, we measured sociodemographics, clinical variables, and cancer specific general distress. At follow-up (Median = 5.0 years; Range 3.4–9.1...
Abstract Genetic counseling and testing for hereditary breast cancer have the potential benefit of early detection interventions in African American women. However, women low use these services compared to White We conducted two focus groups with diagnosed (affected group, n = 13) at least one first‐degree relative breast/ovarian (unaffected 8). A content analysis approach was employed analyze interview data. Breast survivors had more knowledge about genetic than participants who were...
Abstract Telephone genetic counseling (TC) for hereditary breast/ovarian cancer risk has been associated with positive outcomes in high women. However, little is known about how patients perceive TC. As part of a randomized trial TC versus usual care (UC; in‐person counseling), we compared women's perceptions of: (1) overall satisfaction counseling; (2) convenience; (3) attentiveness during the session; (4) counselor effectiveness providing support; and (5) ability to recognize emotional...
Breast cancer is the most common diagnosed among Latinas in United States and leading cause of cancer-related death this population. tend to be at a later stage have worse prognostic features than their non-Hispanic white counterparts. Genetic genomic factors may contribute observed breast health disparities Latinas.We provide landscape our current understanding existing gaps that need filled across prevention control continuum.We summarize available data on mutations high moderate...
Latino adults experience multiple barriers to health care access and treatment that result in tobacco-related disparities. Mobile interventions have the potential deliver smoking cessation among adults, who show highest use rates of mobile technologies.
<i>Background:</i> Advances in genomics may eventually lead to ‘personalized genetic medicine,’ yet the clinical utility of predictive testing for modest changes risk is unclear. We explored interest genes related breast cancer women at moderate high cancer. <i>Methods:</i> Women (n = 105) with a negative biopsy and ≧1 relative or ovarian completed telephone surveys. measured demographic psychosocial variables and, following presentation hypothetical scenarios tests...
PURPOSE Our purpose was to describe the prevalence and predictors of symptom function clusters related physical, emotional, social components general health-related quality life (HRQOL) in a population-based sample prostate cancer (PCa) survivors. METHODS Participants (N = 1,162) completed baseline survey at median 9 months after diagnosis ascertain co-occurrence eight functional domains that are common across all cancers not treatment-specific. We used latent profile analysis (LPA) identify...
Abstract Background: Responses following BRCA1/2 genetic testing are relevant for the comprehension of risk status and may play a role in management decision making. The objective this study was to evaluate psychosocial telephone counseling (PTC) intervention delivered mutation carriers standard (SGC). We examined effect on distress concerns related testing. Methods: This prospective randomized clinical trial included 90 carriers. measured anxiety, depression, outcomes at baseline 6 12...