A5065294000- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Microbial Metabolic Engineering and Bioproduction
- PI3K/AKT/mTOR signaling in cancer
- Biochemical and Molecular Research
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- Metabolomics and Mass Spectrometry Studies
- Neurogenesis and neuroplasticity mechanisms
- Cell Image Analysis Techniques
- Toxin Mechanisms and Immunotoxins
- ATP Synthase and ATPases Research
University of Padua
2020-2025
Recent proteomic, metabolomic, and transcriptomic studies have highlighted a connection between changes in mitochondria physiology cellular pathophysiological mechanisms. Secondary assays to assess the function of these organelles appear fundamental validate -omics findings. Although mitochondrial membrane potential is widely recognized as an indicator activity, high-content imaging-based approaches coupled multiparametric measure it not been established yet. In this paper, we describe...
Neural progenitor cells (NPCs) are often used to study the subcellular mechanisms underlying differentiation into neurons in vitro. Works published date have focused on pathways that distinguish undifferentiated NPCs from mature neurons, neglecting earlier and intermediate stages of this process. Current evidence suggests mitochondria interaction with ER is fundamental a wide range intracellular processes. However, it not clear whether how mitochondria–ER interactions differ between their...
Introduction: Biallelic variants in PITRM1 are associated with a slowly progressive syndrome characterized by intellectual disability, spinocerebellar ataxia, cognitive decline and psychosis. The pitrilysin metallopeptidase 1 (PITRM1) is mitochondrial matrix enzyme, which digests diverse oligopeptides, including the targeting sequences (MTS) that cleaved from proteins imported across inner membrane processing peptidase (MPP). Mitochondrial peptidases also play role maturation of Frataxin,...
Neuroblastoma (NB) is the most common extracranial tumor of early childhood and accounts for 15% all pediatric cancer mortalities. However, precise pathways genes underlying its progression are unknown. Therefore, we performed a differential gene expression analysis neuroblastoma stage 1 4 + 4S to discover biological processes associated with NB progression. From this preliminary analysis, found that samples (stage 4S) characterized by altered some proteins involved in mitochondria function...