A5070594897- Endoplasmic Reticulum Stress and Disease
- RNA Research and Splicing
- RNA regulation and disease
- Bone health and treatments
- Heat shock proteins research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Mitochondrial Function and Pathology
- Insect symbiosis and bacterial influences
- Viral Infections and Vectors
- TGF-β signaling in diseases
- ATP Synthase and ATPases Research
- Mosquito-borne diseases and control
- Autophagy in Disease and Therapy
- Vitamin C and Antioxidants Research
Heidelberg University
2020-2024
University Hospital Heidelberg
2023-2024
Jewish Hospital
1989
Washington University Medical Center
1989
Shriners Hospitals for Children - St. Louis
1989
Cardinal Glennon Children’s Medical Center
1989
The integrated stress response (ISR) is a key cellular signaling pathway activated by environmental alterations that represses protein synthesis to restore homeostasis. To prevent sustained damage, the ISR counteracted upregulation of growth arrest and DNA damage-inducible 34 (GADD34), stress-induced regulatory subunit phosphatase 1 mediates translation reactivation recovery. Here, we uncover novel mechanism post-transcriptionally controls stability PPP1R15A mRNA encoding GADD34. We...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remodels the endoplasmic reticulum (ER) to form replication organelles, leading ER stress and unfolded protein response (UPR). However, role of specific UPR pathways in infection remains unclear. Here, we found that SARS-CoV-2 causes marginal activation signaling sensor IRE1α its phosphorylation, clustering dense ER-membrane rearrangements with embedded membrane openings, XBP1 splicing. By investigating factors regulated by...
Cells of the clonal rat osteogenic sarcoma cell line, UMR 106-01, were used to investigate regulation collagen synthesis by PTH in osteoblastic cells. Monolayer cultures cells labeled with [3H] proline order determine both type and rates production. Analysis extracellular polypeptides on sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that 106-01 synthesized predominantly I collagen, accounting for 45.48 ± 2.09% radioactivity incorporated into total protein. After 24-h...
Summary The integrated stress response (ISR) is a key cellular signaling pathway activated by environmental alterations that represses protein synthesis to restore homeostasis. To prevent sustained damage, the ISR counteracted upregulation of Growth Arrest and DNA Damage inducible 34 (GADD34), stress-induced regulatory subunit phosphatase 1 mediates translation reactivation recovery. Here, we uncover novel mechanism post-transcriptionally controls stability PPP1R15A mRNA encoding GADD34. We...