A5040731842- Ocular Diseases and Behçet’s Syndrome
- Immune Cell Function and Interaction
- Ocular Infections and Treatments
- Retinal and Optic Conditions
- T-cell and B-cell Immunology
- Immune cells in cancer
- Diabetes and associated disorders
- Pancreatic function and diabetes
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Bartonella species infections research
- Mosquito-borne diseases and control
- Retinal Diseases and Treatments
- Cytokine Signaling Pathways and Interactions
- Vasculitis and related conditions
- Immune responses and vaccinations
- Herpesvirus Infections and Treatments
- Chemokine receptors and signaling
- Metabolism, Diabetes, and Cancer
- Sarcoidosis and Beryllium Toxicity Research
- Complement system in diseases
University of Basel
2015-2025
University Hospital of Basel
2019-2025
Assistance Publique – Hôpitaux de Paris
2024-2025
Université Paris Cité
2024
Hôpital Cochin
2024
Expansion and acquisition of Th1 cell effector function requires metabolic reprogramming; however, the signals instructing these adaptations remain poorly defined. Here we found that in activated human T cells, autocrine stimulation complement receptor CD46, specifically its intracellular domain CYT-1, was required for induction amino acid (AA) transporter LAT1 enhanced expression glucose GLUT1. Furthermore, CD46 activation simultaneously drove LAMTOR5, which mediated assembly AA-sensing...
The mitochondrial activity and antitumor function of human helper T cells are suppressed by a tumor-derived cytokine.
Abstract Effector memory (EM) CD4+ T cells recirculate between normoxic blood and hypoxic tissues to screen for cognate Ag. How mitochondria of these cells, shuttling normoxia hypoxia, maintain bioenergetic efficiency stably uphold antiapoptotic features is unknown. In this study, we found that human EM had greater spare respiratory capacity (SRC) than did naive counterparts, which was immediately accessed under hypoxia. Consequently, maintained ATP levels, survived migrated better hypoxia...
Birdshot chorioretinitis (BSCR) is a chronic bilateral posterior uveitis, which can affect central as well peripheral vision. The aim of this study was to assess how visual acuity and field evolved over time in patients with BSCR.
Interleukin (IL)-7 promotes T cell expansion during lymphopenia. We studied the metabolic basis in CD4
Purpose The presentation of ocular sarcoidosis may involve different parts the eye and/or adnexal tissues. Uveitis is most common manifestation, and when it involves posterior segment, often presents as peripheral multifocal choroiditis. occurrence symptomatic occlusive retinal vasculitis (ORV) associated with not well described in literature. objective this article to describe characterized cases biopsy-proven presenting ORV.
Aims This study aims to analyse peripapillary atrophy (PPA), its frequency, extent and relation with measures of visual function in patients birdshot chorioretinitis (BSCR). Methods Patients the single-centre prospective COhort BIRDshot (ClinicalTrials.gov Identifier: NCT05153057 ) were included. The areas optic nerve head (ONH) PPA measured on red–green autofluorescence fundus images acquired by ultrawidefield retinal photography. main outcome measure was frequency PPA. Correlations between...
Birdshot chorioretinitis (BSCR) is an ocular HLA-related disease with variable clinical progression. We examine the quality of life (QOL) BSCR individuals aged ≥80 years, providing insights into long-term impact.
Purpose: HLA-A29 is the main susceptibility factor for birdshot chorioretinitis (BSCR). Our study assessed impact of second HLA-A allele alongside on BSCR severity and susceptibility, focusing homozygous patients those with alleles from HLA-Aw19 group. Methods: We included 120 additional cases to our previous analysis 286 BSCR, all positive. Patients were categorized based being also (A29/nonA29 vs. A29/A29) or belonging family, including A29, A30, A31, A33 (A29/nonAw19 A29/Aw19). HLA-A32...