A5100723092- Pulmonary Hypertension Research and Treatments
- Circular RNAs in diseases
- RNA modifications and cancer
- Frequency Control in Power Systems
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Sarcoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Neuropeptides and Animal Physiology
- Glioma Diagnosis and Treatment
- Inflammasome and immune disorders
- Brain Metastases and Treatment
- Nonlinear Differential Equations Analysis
- Cancer, Stress, Anesthesia, and Immune Response
- Domain Adaptation and Few-Shot Learning
- Head and Neck Surgical Oncology
- Advanced Neural Network Applications
- Multimodal Machine Learning Applications
- Cancer, Hypoxia, and Metabolism
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tracheal and airway disorders
- Protein Structure and Dynamics
- Antimicrobial Peptides and Activities
- Signaling Pathways in Disease
Qiqihar Medical University
2025
Southern University of Science and Technology
2023-2024
Jinan University
2023-2024
Harbin Medical University
2019-2024
University of Chicago
2024
Daqing City People's Hospital
2019-2024
Fudan University
2015-2017
Shandong University of Science and Technology
2017
Beijing Institute of Neurosurgery
2012
Capital Medical University
2012
[Figure: see text].
BACKGROUND: Pulmonary hypertension, characterized by vascular remodeling, currently lacks curative therapeutic options. The dysfunction of pulmonary artery endothelial cells plays a pivotal role in the initiation and progression hypertension (PH). ErbB3 (human epidermal growth factor receptor 3), also recognized as HER3, is member ErbB family tyrosine kinases. METHODS: Microarray, immunofluorescence, Western blotting analyses were conducted to investigate pathological ErbB3. Blood samples...
Hypoxia and oxidative stress contribute to the development of pulmonary hypertension (PH). tRNA-derived fragments play important roles in RNA interference cell proliferation, but their epitranscriptional PH have not been investigated. We aimed gain insight into mechanistic contribution stress-induced 8-oxoguanine vascular remodeling.
Pulmonary artery smooth muscle cell proliferation is the pathological basis of pulmonary vascular remodeling in hypoxic hypertension. Recent studies suggest that circular RNA (circRNA) can regulate various biological processes, including proliferation. Therefore, it possible circRNA may have important roles In present study, we aimed to identify functional circRNAs and clarify their mechanisms sequencing identified 67 were differentially expressed lung tissues mice. Screening by...
Pulmonary hypertension (PH) is a clinically common malignant cardiovascular disease. Pyroptosis new form of inflammatory cell death that involved in many disease processes. Glioma-associated oncogene family zinc finger 1 (GLI1) transcriptional activator participates diseases, but its role has never been explored inducing pyroptosis and the progress PH. In this study, we used an animal model molecular biology to determine effect GLI1 on chronic hypoxia-mediated PH progression pulmonary artery...
Abstract Circular RNAs (circRNAs) are a class of non-coding with loop structure; however, their functions remain largely unknown. Growing evidence suggests that circRNAs play pivotal role in the progression malignant diseases. However, expression profiles and function hepatocellular carcinoma (HCC) unclear. We investigated microtubule-associated serine/threonine kinase 1 (MAST1) circRNA (circMAST1) HCC healthy tissues using bioinformatics, quantitative real-time PCR (qRT-PCR), fluorescence...
Pulmonary hypertension (PH) is an extremely malignant pulmonary vascular disease of unknown etiology. ADAR1 RNA editing enzyme that converts adenosine in to inosine, thereby affecting expression. However, the role PH development remains unclear. In present study, we investigated biological and molecular mechanism remodeling. Overexpression aggravated progression promoted proliferation artery smooth muscle cells (PASMCs). Conversely, inhibition produced opposite effects. High-throughput whole...
Lung cancer represents a significant global health burden, with non-small cell lung (NSCLC) being the most common subtype. The current standard of care for NSCLC has limited efficacy, highlighting necessity innovative treatment options. Lidocaine, traditionally recognized as local anesthetic, emerged compound potential antitumor and anti-inflammatory capabilities. This study was designed to explore impact lidocaine on proliferation inflammation, particularly focusing Toll-like receptor 9...
Pulmonary hypertension is a rare, progressive disorder that can lead to right ventricular hypertrophy, heart failure, and even sudden death. N6-methyladenosine modification the main methyltransferase mediates it, methyltransferase-like (METTL) 3, exert important effects on many biological pathophysiological processes. However, role of METTL3 in pyroptosis remains unclear.
Piwi-interacting RNAs (piRNAs) are thought to be germline-specific and involved in maintaining genome stability during development. Recently, piRNA expression has been identified somatic cells diverse organisms. However, the roles of piRNAs pulmonary arterial smooth muscle cell (PASMC) proliferation molecular mechanism underlying hypoxia-regulated pathological process hypertension not well understood. Using hypoxic animal models, biology, we obtained first evidence that piRNA-63076 was...
OBJECTIVE The overall survival and pertinent adverse factors for primary intracranial malignant melanoma (PIMM) have not been previously determined. This aim of this study was to determine the rates progression-free (PFS) (OS) identify PIMM. METHODS included 15 cases from authors’ own series 100 with detailed clinical data that were obtained literature 1914 2018 using Ovid Medline, EMBASE, PubMed, Cochrane, EBSCO databases. Patient demographics, treatment (surgery, chemotherapy, radiotherapy...
Pyroptosis is involved in pulmonary hypertension (PH); however, whether this process regulated by long non-coding RNAs (lncRNAs) unclear. Some lncRNAs encode peptides; therefore, the regulation of pyroptosis PH depends on themselves or their encoded peptides needs to be explored. We aimed characterize role peptide RPS4XL lnc-Rps4l and its regulatory mechanisms during PH. Transgenic mice overexpression was established rescue inhibition hypoxia-induced artery smooth muscle cells (PASMCs). An...
Deep neural networks (DNNs) often suffer from "catastrophic forgetting" during incremental learning (IL) --- an abrupt degradation of performance on the original set classes when training objective is adapted to a newly added classes. Existing IL approaches tend produce model that biased towards either old or new classes, unless with help exemplars data. To address this issue, we propose class-incremental paradigm called Model Consolidation (DMC), which works well even data not available....
The prebiotic formation of RNA building blocks is well‐supported experimentally, yet the emergence sequence‐ and structure‐specific oligomers generally attributed to biological selection via Darwinian evolution rather than chemical selectivity. In this study, we investigated partitioning randomized overhangs into ligated products these two competing pathways using deep sequencing. Comprehensive sequence‐reactivity profiles revealed that loop‐closing ligation preferentially yields hairpin...
The prebiotic formation of RNA building blocks is well‐supported experimentally, yet the emergence sequence‐ and structure‐specific oligomers generally attributed to biological selection via Darwinian evolution rather than chemical selectivity. In this study, we investigated partitioning randomized overhangs into ligated products these two competing pathways using deep sequencing. Comprehensive sequence‐reactivity profiles revealed that loop‐closing ligation preferentially yields hairpin...
While the prebiotic synthesis of building blocks life is well supported experimentally, no chemical process known to selectively yield common biological RNA sequences and structures. oligomers carrying functional information are generally believed emerge from a large pool random as result Darwinian evolution. Herein, we profiled nonenzymatic partitioning randomized overhangs into ligated products via two competing pathways: loop-closing ligation splint-directed ligation, using deep...
We investigate in this paper the following second-order multipoint boundary value problem:<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mo>-</mml:mo><mml:mo stretchy="false">(</mml:mo><mml:mi>L</mml:mi><mml:mi>φ</mml:mi><mml:mo stretchy="false">)</mml:mo><mml:mo stretchy="false">(</mml:mo><mml:mi>t</mml:mi><mml:mo stretchy="false">)</mml:mo><mml:mo>=</mml:mo><mml:mi>λ</mml:mi><mml:mi>f</mml:mi><mml:mo...