A5038664061- Cancer Research and Treatments
- Virus-based gene therapy research
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- Mesenchymal stem cell research
- Nanoparticle-Based Drug Delivery
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced Drug Delivery Systems
- Pancreatic and Hepatic Oncology Research
- Bacteriophages and microbial interactions
- Tissue Engineering and Regenerative Medicine
- Nanoplatforms for cancer theranostics
- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- CRISPR and Genetic Engineering
- Autophagy in Disease and Therapy
- Cell death mechanisms and regulation
- Extracellular vesicles in disease
- Mitochondrial Function and Pathology
North Dakota State University
2016-2023
University of Nebraska Medical Center
2021-2023
Biological nanoparticles, such as exosomes, offer an approach to drug delivery because of their innate ability transport biomolecules. Exosomes are derived from cells and integral component cellular communication. However, the cargo human exosomes could negatively impact use a safe carrier. Additionally, have intrinsic yet enigmatic, targeting characteristics complex Hence, harnessing natural abilities for requires predictably these biological nanoparticles. This manuscript describes two...
Apoptosis inducing factor (AIF) plays a well-defined role in controlling cell death but is also critical for maintaining mitochondrial energy homeostasis; how these dueling activities are balanced has remained largely elusive. To identify new AIF binding partners that may define the continuum of cellular regulation, biochemical screen was performed identified phosphoglycerate mutase 5 (PGAM5) as an associated factor. binds both short and long isoforms PGAM5 can reduce ability to control...
Clostridium novyi has demonstrated selective efficacy against solid tumors largely due to the microenvironment contained within dense tumor cores. The core of a is typically hypoxic, acidic, and necrotic—impeding penetration current therapeutics. C . attracted once there, can both lyse proliferate while simultaneously re-activating suppressed immune system. systemic toxicity easily mitigated by knocking out phage DNA plasmid encoded alpha toxin resulting in -NT; but, after intravenous...
The tumor microenvironment is characterized by anomalous vascularization, hypoxia, and acidity at the core of solid tumors that culminates in concentrated necrosis immune system dysregulation among other effects. While this environment presents several challenges for development oncotherapeutics deliver their activity via enhanced permeability retention (EPR) effect leaky blood vessels around a tumor, oncolytic bacteria, or class bacteria with noted capacity to lyse tumors, are attracted...
Pancreatic cancer presents a unique challenge for the development of effective oncotherapies. The tumor microenvironment (TME) this type typically contains dense desmoplastic barrier composed aberrant extracellular matrix proteins, as well an acidic, hypoxic and necrotic core. Additionally, immune system surrounding has often been suppressed by TME. Hence, choosing correct model within which to test potential anti-cancer therapy is critical experimental design decision. While typical solid...
Abstract The efficacy of current oncotherapeutics is largely limited by an inability to access avascular tissues, which in part responsible for forty years stagnant pancreatic cancer statistics where the median survival remains a mere six months. Oncolytic bacteria such as Clostridium novyi-NT overcome this challenge with its ultrasensitive, innate affinity hypoxic/necrotic areas found at center solid tumors and their metastases. While preclinical clinical data from intratumoral injections...