A5014313085- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Endometriosis Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Gynecological conditions and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Computational Drug Discovery Methods
- Reproductive System and Pregnancy
- Hematopoietic Stem Cell Transplantation
- Sarcoma Diagnosis and Treatment
- Prenatal Screening and Diagnostics
- Immune Cell Function and Interaction
- BRCA gene mutations in cancer
- Assisted Reproductive Technology and Twin Pregnancy
- Hemoglobinopathies and Related Disorders
- Ectopic Pregnancy Diagnosis and Management
- Maternal and fetal healthcare
- Phosphodiesterase function and regulation
- Reproductive Biology and Fertility
- Biotechnology and Related Fields
- Pelvic floor disorders treatments
- Nicotinic Acetylcholine Receptors Study
Tel Aviv Sourasky Medical Center
2016-2025
Tel Aviv University
2016-2025
Sheba Medical Center
1996-2022
Gynecologic Oncology Group
2019-2020
Arthur M. Sackler Gallery
2020
Beijing Obstetrics and Gynecology Hospital
2007
University Health Network
2007
Wolfson Medical Center
2006
Assaf Harofeh Medical Center
2006
Gynecologic Oncology Associates
2005
Cancer-associated fibroblasts (CAFs) are highly prominent in breast tumors, but their functional heterogeneity and origin still largely unresolved. We report that bone marrow (BM)-derived mesenchymal stromal cells (MSCs) recruited to primary tumors lung metastases differentiate a distinct subpopulation of CAFs. show BM-derived CAFs functionally important for tumor growth enhance angiogenesis via up-regulation Clusterin. Using newly generated transgenic mice adoptive BM transplantations, we...
To explore the scope and significance of alternate promoter usage its putative inter-relationship to alternative splicing, we searched expression sequence tags for 5′ region acetylcholinesterase (ACHE) genes. Three five novel first exons were identified in human mouse ACHE genes, respectively. Reverse transcription-PCR situ hybridization validated most predicted transcripts, analyses corresponding genomic DNA regions suggest evolutionarily conserved promoters each identified. Distinct tissue...
Epithelial ovarian cancer (EOC) is usually discovered after extensive metastasis have developed in the peritoneal cavity. The surface exposed to fluid pressures and shear forces due continuous peristaltic motions of gastro-intestinal system, creating a mechanical micro-environment for cells. An vitro experimental model was expose EOC cells steady flow induced wall stresses (WSS). were cultured from OVCAR-3 cell line on denuded amniotic membranes special wells. Wall 0.5, 1.0 1.5 dyne/cm2...
Background Approximately 70% of women diagnosed with advanced‐stage ovarian cancer experience disease recurrence. Survival data were compared between a group recurrent epithelial (rEOC) patients treated by cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC) matched rEOC systemic only (without surgery). Treatment outcome in relation to the patients' BRCA status was compared. Methods Twenty‐seven HIPEC selected from our database (1:3) 84 only. Progression‐free survival (PFS)...
Psychological stress induces rapid and long-lasting changes in blood cell composition, implying the existence of stress-induced factors that modulate hematopoiesis. Here we report involvement stress-associated "readthrough" acetylcholinesterase (AChE-R) variant, its 26 amino acid C-terminal domain (ARP) hematopoietic responses. We studied effects stress, cortisol, antisense oligonucleotides to AChE, synthetic ARP on peripheral composition clonogenic progenitor status mice under normal...
Thromboembolic complications in beta-thalassemia major have seldom been reported and their association with risk factors such as left ventricular failure postsplenectomy thrombocytosis has remained speculative. In this report we describe 4 patients unusual thromboembolic manifestations: recurrent arterial occlusion, pulmonary thromboembolism, venous thrombosis a fatal cerebrovascular event. Although all both were present, the precise causes for not identified. 1 patient, however, marked...
Endurance, marathon-type exertion is known to induce adverse changes in the immune system. Increased airway hyper-responsiveness and inflammation are well documented endurance athletes exercise considered a major risk factor for asthma elite athletes. Yet, mechanisms underlying this phenomenon still be deduced. We studied effect of strenuous (marathon half-ironman triathlon) on CD4+ lymphocyte sub-populations balance between effector regulatory lymphocytes peripheral blood trained athletes,...
The objective of this study was to examine the influence histology on outcome patients with surgically treated, Stage IA-IB carcinoma uterine cervix.All patient information collected prospectively and extracted subsequently from University Toronto cervical surgery data base. Selection criteria for were based tumor size independent histology. Patients adenocarcinoma separated into two groups: those mucinous/endometrioid (M/E AC) adenosquamous/clear cell (AS/CC AC). Statistical analysis used...
The extended human acetylcholinesterase (AChE) promoter contains many binding sites for osteogenic factors, including 1,25-(OH)2 vitamin D3 and 17beta-estradiol. In differentiating osteosarcoma Saos-2 cells, both of these factors enhanced transcription the AChE mRNA variant 3' terminated with exon 6 (E6-AChE mRNA), which encodes catalytically morphogenically active E6-AChE isoform. contrast, antisense oligodeoxynucleotide suppression expression increased proliferation in a dose-...
Abstract Glucocorticoid-initiated granulocytosis, excessive proliferation of granulocytes, persists after cortisol levels are lowered, suggesting the involvement additional stress mediator(s). In this study, we report that stress-induced acetylcholinesterase variant, AChE-R, and its cleavable, cell-penetrating C-terminal peptide, ARP, facilitate granulocytosis. postdelivery patients, AChE-R-expressing granulocyte counts increased concomitantly with serum AChE activity levels, yet persisted...
Objective: Clinically suspected appendicitis is the most common nonobstetric surgical problem encountered in pregnancy. The diagnosis of hampered by equivocal symptoms during Ultrasonography (US) remains, as a rule, imaging test choice for clinically pregnancy and other tools such computed tomography (CT) or magnetic resonance (MRI) are usually avoided. We evaluated accuracy US pregnancy.Methods: clinical sonographic findings all pregnant women (n = 90), who underwent appendectomy between...