A5036360076- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Treatment of Major Depression
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Psychedelics and Drug Studies
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Olfactory and Sensory Function Studies
- Zebrafish Biomedical Research Applications
- Pain Mechanisms and Treatments
- Nerve injury and regeneration
- Behavioral Health and Interventions
- Ginkgo biloba and Cashew Applications
- Pharmacological Receptor Mechanisms and Effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plant Extracts Effects
- Urban Green Space and Health
- Medicinal Plants and Neuroprotection
- Eating Disorders and Behaviors
University of Verona
2016-2024
University of Palermo
2024
University of Milan
2022
University of Trieste
2013
Abstract Ketamine and MK-801 by blocking NMDA receptors may induce reinforcing effects as well schizophrenia-like symptoms. Recent results showed that ketamine can also effectively reverse depressive signs in patients’ refractory to standard therapies. This evidence clearly points the need of characterization these NMDARs antagonists on relevant brain areas for mood disorders. The aim present study was investigate molecular changes occurring at glutamatergic synapses 24 h after or treatment...
Abstract Environmental enrichment (EE) has been shown to produce beneficial effects in addiction disorders; however, due its configurational complexity, the underlying mechanisms are not yet fully elucidated. Recent evidence suggests that EE, acting as a metaplastic agent, may affect glutamatergic appetitive memory and, turn, modulate reward‐seeking behaviours: here, we have investigated such possibility following brief EE exposure. Adult male Sprague–Dawley rats were exposed for 22 h and...
This narrative review describes the research on effects of association between environmental context and medications, suggesting benefit specific design interventions in adjunction to pharmacotherapy. The literature Evidence-Based Design (EBD) studies Neuro-Architecture show how contact with light, nature, physical features urban interior architecture may enhance analgesic, anxiolytics, antidepressant drugs. interaction mirrors those already known psychedelics, drugs abuse, setting....
Despite several decades of investigations, the mechanisms underlying rapid action ketamine as antidepressant are still far from being completely understood. Several studies indicated Brain-Derived Neurotrophic Factor (BDNF) critical for fast ketamine, due to its contribution in early and synaptic adaptations. However, previous reports have been essentially based on dosing modes that differ clinical route administration (slow intravenous infusion). In this report, we investigated effects a...
Environmental enrichment (EE) is a non-pharmacological approach that has been shown to be effective in reducing food-taking rats. Studies human volunteers are still their infancy, given the difficulty translate complexity of EE clinical practice. Virtual reality (VR) promising methodological approach, but no study yet applied it model and test humans.
Abstract Rationale Several single or combined therapeutic approaches have been developed to treat addiction, however with partial efficacy in preventing relapse. Recently, the living environment has suggested as a critical intervening factor determining treatment outcomes. Despite accumulating evidence confirming role of conditions vulnerability addictive behaviours, their impact on integrative strategies relapse is yet be identified. Objectives Here, we explore possible interaction between...
Environmental enrichment (EE) has been shown to produce beneficial effects in addiction disorders; however, due its configurational complexity, the underlying mechanisms are not yet fully elucidated. Recent evidence suggests that EE, acting as a metaplastic agent, may affect glutamatergic appetitive memory and, turn, modulate reward-seeking behaviors: here, we have investigated such possibility following brief EE exposure. Adult male Sprague-Dawley rats were exposed for 22h and expression of...
Abstract Environmental enrichment (EE) has been shown to produce beneficial effects in addiction disorders; however, due its complexity, the underling mechanisms are not yet fully elucidated. Recent evidence suggests that EE, acting as a metaplastic agent, may affect glutamatergic underlying appetitive memory and turn, modulate reward-seeking behaviors. Here, we explore hypothetical induced by brief EE exposure on transmission brain areas involved rewarding processes. Adult male...