A5085402170- Pluripotent Stem Cells Research
- Hedgehog Signaling Pathway Studies
- Cellular Mechanics and Interactions
- Kruppel-like factors research
- 3D Printing in Biomedical Research
- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Hippo pathway signaling and YAP/TAZ
- Epigenetics and DNA Methylation
King's College London
2019-2021
STMicroelectronics (United Kingdom)
2019
Tissue engineering strategies often aim to direct tissue formation by mimicking conditions progenitor cells experience within native tissues. For example, create cartilage in vitro, researchers replicate the biochemical and mechanical milieu during developing limb bud. This includes stimulating progenitors with TGF-β1/3, culturing under hypoxic conditions, regulating mechanosensory pathways using biomaterials that control substrate stiffness and/or cell shape. However, as differentiate down...
ABSTRACT In human, mutations of the protocadherins FAT4 and DCHS1 result in Van Maldergem syndrome, which is characterised, part, by craniofacial abnormalities. Here, we analyse role Dchs1-Fat4 signalling during osteoblast differentiation mouse. We show that Fat4 Dchs1 mutants mimic phenotype human syndrome essential for differentiation. Dchs1/Fat4 mutants, proliferation osteoprogenitors increased delayed. loss linked to Yap-Tead activity Yap expressed required osteoprogenitors. contrast,...