A5003352739- Microtubule and mitosis dynamics
- Microbial Community Ecology and Physiology
- Lipid Membrane Structure and Behavior
- Nonlinear Dynamics and Pattern Formation
- Photoreceptor and optogenetics research
- DNA Repair Mechanisms
- Photosynthetic Processes and Mechanisms
- Cancer-related Molecular Pathways
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Algal biology and biofuel production
- Biocrusts and Microbial Ecology
- Cellular Mechanics and Interactions
KU Leuven
2020-2024
University of Namur
2022
Traveling waves play an essential role in coordinating mitosis over large distances, but what determines the spatial origin of mitotic remains unclear. Here, we show that such initiate at pacemakers, regions oscillate faster than their surroundings. In cell-free extracts
Each proliferating cell replicates its DNA and internal components before distributing this material evenly to daughters. Although the regulation of cyclin-dependent kinases (Cdks) that dictate orderly cycle progression is well characterized, how subcellular localization machinery contributes timing not understood. We investigated influence nucleus by reconstituting oscillations in droplets frog egg extract absence or presence a nuclear compartment monitoring dynamics time-lapse microscopy....
In the context of breast cancer metastasis study, we have shown in an vitro model cell migration that IGDQ-exposing (IsoLeu-Gly-Asp-Glutamine type I Fibronectin motif) monolayers (SAMs) on gold sustain adhesion MDA-MB-231 cells by triggering Focal Adhesion Kinase and integrin activation. Such tunable scaffolds are used to mimic tumor extracellular environment, inducing controlling migration. The observed migratory behavior induced IGDQ-bearing peptide gradient along surface allows separate...
Spiral waves are a well-known phenomenon in excitable media, playing critical roles biological systems such as cardiac tissues, where they involved arrhythmias, and slime molds, guide collective cell migration. However, their presence the cytoplasm of cells has not been reported to date. In this study, we present observation spiral Xenopus laevis frog egg extract reconstituting periodic cycle transitions. We find that emergence these accelerates division nearly twofold. Using two distinct...
In April 2022, The Company of Biologists hosted their first post-pandemic in-person Workshop at Buxted Park Country House in the Sussex countryside. Workshop, entitled 'Cell size and growth: from single cells to tree life', gathered a small group early-career senior researchers with expertise cell spanning broad range organisms, including bacteria, yeast, animal cells, embryos plants, working fields biology ecology evolutionary biology. programme made ample room for fruitful discussions...