A5100412769- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Microstructure and Mechanical Properties of Steels
- Metal Alloys Wear and Properties
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
- Advanced Proteomics Techniques and Applications
- Metallurgy and Material Forming
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Immune Cell Function and Interaction
- Melanoma and MAPK Pathways
- Gastric Cancer Management and Outcomes
- Bioactive Compounds and Antitumor Agents
- Gene expression and cancer classification
- Cytokine Signaling Pathways and Interactions
- Image and Signal Denoising Methods
- Helicobacter pylori-related gastroenterology studies
- ATP Synthase and ATPases Research
- Ubiquitin and proteasome pathways
- Speech and Audio Processing
- Gastroesophageal reflux and treatments
- Aluminum toxicity and tolerance in plants and animals
- Epigenetics and DNA Methylation
Zhengzhou University
2011-2024
Shanxi Medical University
2023
Loma Linda University
2016-2019
University of Kansas
2013
The University of Texas at El Paso
2011
Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers in China. The lower survival rate ESCC attributed to late diagnosis and poor therapeutic efficacy; therefore, identification tumor-associated proteins as biomarkers for early diagnosis, discovery novel targets intervention, seems very important increasing ESCC. To identify ESCC, we have analyzed tissues adjacent normal by two-dimensional electrophoresis (2DE) matrix-assisted laser desorption/ionization-time-of-flight...
Glutamate dehydrogenase 1 (GLUD1) is an important enzyme in glutamine metabolism. Previously, we found GLUD1 was down-regulated tumor tissues of hepatocellular carcinoma (HCC) patients by proteomics study. To explore its role the progression HCC, expressional level firstly examined and presented as that both protein mRNA levels were compared to normal liver tissues. overexpression significantly inhibited HCC cells proliferation, migration, invasion growth vitro vivo, while knocking-down...
Current therapies for gut inflammation have not reached the desired specificity and are attended by unintended immune suppression. This study aimed to provide evidence supporting a hypothesis that direct in vivo augmentation of induction gut-homing regulatory T (Treg) cells is strategy expected treatment chronic intestinal (e.g., inflammatory bowel disease). We showed dendritic (DCs), engineered de novo produce high concentrations both 1,25-dihydroxyvitamin D, active vitamin D metabolite,...
Lysine acetylation is a vital post-translational modification (PTM) of proteins, which plays an important role in cancer development. In healthy human liver tissues, multiple non-histone proteins were identified with modification, however, the acetylated hepatocellular carcinoma (HCC) development remains largely unknown. Here we performed quantitative acetylome study tumor and normal tissues from HCC patients. Overall, 598 lysine sites 325 quantified, almost 59% their levels significantly...
Epidemiological studies from diverse global regions suggest a correlation between the accumulation of aluminum in brain and onset various neurodegenerative diseases, including Alzheimer's disease, which, neuronal cells death happen. Our previous research has found potential to induce cell death. A comprehensive exploration regulatory pathways influenced by could contribute development strategies aimed at preventing detrimental impact on cells. This study is dedicated exploring mitochondrial...
Multiple sclerosis (MS) is caused by immune-mediated damage of myelin sheath. Current therapies aim to block such immune responses. However, this blocking not sufficiently specific and hence compromises immunity, leading severe side effects. In addition, medications usually provide transient effects require frequent administration, which further increases the chance compromise immunity. regard, myelin-specific therapy may desired specificity a long-lasting therapeutic effect inducing...
Abstract Background Hepatocellular carcinoma (HCC) is aggressive liver cancer. Despite advanced imaging and other diagnostic measures, HCC in a significant portion of patients had reached the stage at first diagnosis. Unfortunately, there no cure for HCC. As result, still leading cause cancer death, pressing need new markers therapeutic targets. Methods We investigated sulfotransferase 1C2 (SUTL1C2), which we recently showed was overexpressed human cancerous tissues. Specifically, analyzed...
Abstract Qa-1 epitopes, the peptides that bind to non-classical major histocompatibility complex Ib molecules and are recognized by Qa-1-restricted CD8 + regulatory T (Treg) cells, have been identified in pathogenic autoimmune cells attack myelin sheath experimental encephalomyelitis (EAE, an animal model for multiple sclerosis [MS]). Additionally, immunization with such epitopes ameliorates EAE. However, identification of requires knowledge which largely unknown MS patients. Hence, we asked...
Hepatocellular carcinoma (HCC) is one of the most frequently diagnosed types cancer in world. Post‑translational modifications, such as phosphorylation, serve an essential role during development. To identify aberrant phosphorylation HCC, a multiplexed tandem mass tag approach combined with liquid chromatography tandem‑mass spectrometry was used present study. The results are available via ProteomeXchange (identifier no. PXD013934). A total 4,780 phosphorylated sites distributed on 2,209...
Epinodosin has shown antibacterial and antitumor biological characteristics in the documents. We found that an effective inhibitory effect on esophageal squamous cell carcinoma (ESCC). However, potential roles mechanisms of ESCC remain unclear. performed many experiments to clarify mechanism ESCC. In this study, viability, invasion, migration, apoptosis were determined by 3-(4,5-dimethyl-2-thiazolyl)-2,-diphenytetrazoliumromide (MTT), Transwell, flow cytometry. The differentially expressed...
To support the nations public sector probe and drug discovery programs, in this paper, we develop a chemical biology data visualization system based on our designed Molecular Libraries Biological Database (MLBD) that tackles limitations of primary repository PubChem website. We highlight system's capability responding to multiple queries simultaneously providing direct comparison their results. Our proposed first-of-its-kind grid (CBDG) can federate large set databases visualize response at...
For panoramic spectrum monitoring, the traditional 50 percent overlapping sub-filter channelization structure has problem of high complexity and hardware resource consumption. Focusing on this, we exploit complementary characteristics transition band sub-filters propose a 25 structure. By doing so, it can reduce number consumption considerably. The simulation results show that proposed also successfully reconstruct non-aliasing non-blind zone as one does, saves about 30
Abstract BCAT1 is up-regulated and acts as an oncogenic factor in many types of cancers, but its role lung adenocarcinoma (LUAD) development not clearly understood. Here we found protein level was tumor tissues, which positively associated with TNM stage local lymph node metastasis LUAD patients. knockdown inhibited cell growth mobility while overexpression promoted both vitro vivo . BCAAs metabolism mitochondrial respiration were enhanced cells, more sensitive to Leucine Isoleucine...