A5088880174- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Energetic Materials and Combustion
- Thermal and Kinetic Analysis
- Synthesis and biological activity
- Click Chemistry and Applications
- Rocket and propulsion systems research
- Combustion and Detonation Processes
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Synthesis and Analysis
- Cancer therapeutics and mechanisms
- Multicomponent Synthesis of Heterocycles
- Peptidase Inhibition and Analysis
- Synthesis and Catalytic Reactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Crystallography and molecular interactions
Indian Institute of Technology Kanpur
2024
National Institute of Technology Kurukshetra
2020-2023
Kurukshetra University
2020-2021
Two libraries of antimicrobial and fluorescent 7-azaindole N -linked benzyl/phenyl 1,2,3-triazole hybrids have been synthesized via Cu (II) catalyzed click reaction. Molecular docking, ADME, Molinspiration DFT studies were also carried out.
1,2,3-Triazole and 1,2,4-triazole have been vigorously used in energetic materials research. Among these two, has a widely backbone designing new with improved performance. This study showed the synthesis of nitrogen-enriched dianionic salts (3–6) based on methylene bridged 3,4-diamino-1,2,4-triazole combined nitrate, perchlorate, picrate, azide anions. Structures 5,5′-methylenedi(4H-1,2,4-triazole-3,4-diamine) its 4 5 were confirmed by single-crystal X-ray diffraction studies, showing...
Aim: To obtain new hybrids derived from isatin and triazole. Materials & methods: A series of oxindole–1-H-1,2,3-triazole (4a–l) were synthesized 3-sulfenylated N-propargylated oxindoles organic azides employing Cu(I)-catalyzed azide–alkyne cycloaddition. These compounds evaluated in vitro for antimicrobial activity by the standard serial dilution method DNA photocleavage activity. Results: Antimicrobial assay revealed that 4l 4f exhibited promising efficacy against Candida albicans Rhizopus...
Abstract In this study, high energy materials (HEMs) derived from 1,2,4‐triazolo[3,4‐d]‐1,2,4‐triazolo[3,4‐f]furazano[3,4‐b]pyrazine (TTFP) substituted with −NH 2 , −NHNO −ONO −NO and −N 3 explosophoric groups were designed computationally characterized. Density functional calculations B3PW91/6‐31G(d,p) method used to explore the optimized structures, energetic properties, sensitivity of TTFP derivatives. It is found that an effective molecular backbone for improving content performance...
The oxadiazole ring is an essential nitrogen-containing heterocycle and a valuable building block that used in developing numerous functionalized energetic compounds.
Eight energetic salts combining N-bases with picrate ion were synthesized in high yields. The structures and properties regulated by the variation of N-base molecules concentration picric acid reaction mixture.
A trifluoromethyl group substituted C-C bonded nitrogen rich energetic material 3-(3-nitro-1
Abstract Nitrogen‐rich polyazole derivatives were designed and synthesized from the commercially available 4,5‐dicyano‐2‐aminoimidazole. The relatively simple synthesis of multiple azole rings in desired compounds with good yields allows for an efficient scale‐up. All characterized by NMR vibrational spectroscopy, elemental analysis, DSC studies. impact friction sensitivities measured BAM apparatus. energy content target was predicted using density functional methods. Performing cautious...
A new class of bis-triazoles linked with ampyrone molecules was synthesized from ampyrone-linked bis-alkyne different benzyl azides under Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. All compounds were characterized by FTIR, 1H-NMR, 13C-NMR, and ESI-MS data. However, the structures solid crystalline 4a 4h finally supported X-ray crystallographic In vitro, antimicrobial activity results alkyne 2 bis-1,2,3-triazoles 4a-4k showed that incorporation triazole units has augmented...