A5035137545- Telomeres, Telomerase, and Senescence
- Congenital heart defects research
- Microplastics and Plastic Pollution
- Corneal Surgery and Treatments
- Mesenchymal stem cell research
- Liver physiology and pathology
- Neurobiology and Insect Physiology Research
- Muscle Physiology and Disorders
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- 14-3-3 protein interactions
- RNA Interference and Gene Delivery
Université de Strasbourg
2019-2020
Centre for Genomic Regulation
2019-2020
Inserm
2019-2020
Institut de génétique et de biologie moléculaire et cellulaire
2019-2020
Centre National de la Recherche Scientifique
2019-2020
Centre National pour la Recherche Scientifique et Technique (CNRST)
2019
Universitat Pompeu Fabra
2017
Barcelona Institute for Science and Technology
2017
Institute of Science and Technology
2017
Senescence is a form of cell cycle arrest induced by stress such as DNA damage and oncogenes. However, while arrested, senescent cells secrete variety proteins collectively known the senescence-associated secretory phenotype (SASP), which can reinforce induce senescence in paracrine manner. SASP has also been shown to favor embryonic development, wound healing, even tumor growth, suggesting more complex physiological roles than currently understood. Here we uncover timely new functions...
Young mammals possess a limited regenerative capacity in some tissues, which is lost upon maturation. We investigated whether cellular senescence might play role such loss during liver regeneration. found that following partial hepatectomy, the senescence-associated genes p21, p16Ink4a, and p19Arf become dynamically expressed different cell types when decreases, but without full senescent response. However, we show treatment with senescence-inhibiting drug improves regeneration, by...
SUMMARY Young mammals possess a limited regenerative capacity in tissues such as the liver, heart and limbs, but which is quickly lost upon maturation or transition to adulthood. Chronic cellular senescence known mediator of decreased tissue function aging disease. Here we investigated whether plays role progressive loss liver that develops young adult mice. We find following partial hepatectomy, markers p21, p16 Ink4a p19 Arf become dynamically expressed at an age when decreases. In...